Classification of Congenital Zika Syndrome: Muscle Tone, Motor Type, Body Segments Affected, and Gross Motor Function

Tavares, Janiele de Sales; Gama, Gabriela Lopes; Borges, Márcia Cristina Dias; Santos, Agda Cristina de Sousa; Amorim, Melânia Maria Ramos; Melo, Adriana

doi:10.1080/17518423.2020.1866706

Cited by 9 publications

(6 citation statements)

References 31 publications

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“…34 This is the first study to investigate this relationship in children with CZS. More studies are necessary to better understand the relationship between urodynamic changes and muscle tone changes presented in children with CZS, 35 and its connection to neurological damage and the chronic use of anticonvulsants and myorelaxants.…”

Section: Discussionmentioning

confidence: 99%

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Ferreira

Pinheiro

Melo

et al. 2022

Tropical Med Int Health

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Objective To describe the urological outcomes in children with congenital Zika syndrome (CZS) and investigate the relationship between clinical and urological findings in this population. Methods This cross‐sectional study involved children with CZS followed up by a referral centre for children with microcephaly in the state of Paraiba in northeast Brazil. The urological evaluation included clinical history, urine culture results, ultrasonography of the urinary tract, and urodynamic evaluation, following the protocol proposed by Costa Monteiro et al. (2017). Descriptive statistical analysis was performed in addition to association and correlation tests, considering clinical and urodynamic variables. Results Among the 88 children with CZS (35.5 ± 5.5 months), 97.7% had microcephaly, and 51% presented urinary tract infection (UTI) confirmed with clinical history and lab tests. The number of confirmed UTI episodes varied from one to 14 per child. The urodynamic evaluation confirmed the presence of an overactive bladder in 78 children and incomplete voiding in 50. Urodynamic findings were associated with the number of confirmed UTI episodes, child's sex, and actual weight, in addition to the use of anticonvulsant and myorelaxant drugs. Conclusions UTIs were confirmed in most children. Other urological outcomes observed were overactive bladder and low bladder capacity, which were associated with the number of confirmed UTI episodes, use of anticonvulsants and myorelaxants, and the child's sex and weight. These are treatable conditions, and it is paramount that paediatricians, neonatologists, and infectious disease specialists are aware of them to make clinical decisions and help reduce the risk of renal damage and other morbidities.

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Section: Discussionmentioning

confidence: 99%

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Ferreira

Pinheiro

Melo

et al. 2022

Tropical Med Int Health

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“…23 As they become older, these children begin to present with axial hypotonia and appendicular hypertonia, making the impaired motor control in the neck and trunk clearly identifiable. 23,24 Added to this, the disappearance of the primitive reflexes of sucking and swallowing, as well as oropharyngeal impairments, can result in nutritional inefficacy, micro-aspiration, nutritional deficiencies and the occurrence of recurrent pneumonia. 23,25 The gains in performing tasks in supine position that require control of the neck and trunk muscles such as lifting the head in the prone and supine positions and rolling, as evaluated in dimension A (laying and rolling) of the GMFM-88, suggest improvement in the activation of the axial muscles that could benefit feeding and minimise secondary complications in children with severe motor impairment, 26 such as the great majority of the children who participated in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Together with hyperreflexia, this could erroneously suggest that the child had achieved neck control 23 . As they become older, these children begin to present with axial hypotonia and appendicular hypertonia, making the impaired motor control in the neck and trunk clearly identifiable 23,24 . Added to this, the disappearance of the primitive reflexes of sucking and swallowing, as well as oropharyngeal impairments, can result in nutritional inefficacy, micro‐aspiration, nutritional deficiencies and the occurrence of recurrent pneumonia 23,25 .…”

Section: Discussionmentioning

confidence: 99%

Effect of neurodevelopmental treatment in children with congenital Zika syndrome: A pilot study

Müller¹,

Gama

Borges³

et al. 2022

J Paediatrics Child Health

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Aim To evaluate the effects of neurodevelopmental treatment (NDT) in children with congenital Zika syndrome (CZS). Methods This prospective, interventional cohort study involved children with CZS undergoing follow‐up at a specialist centre in northeastern Brazil. The duration of the proposed NDT protocol was 1 year, with 45‐min sessions delivered one to five times weekly. Motor function, weight, height, head circumference and the incidence of comorbidities were evaluated in children before protocol initiation and then at 3, 6 and 12 months of treatment. Results Thirty children were evaluated (age mean 30.1 ± 3 months). Motor function improved from baseline to 6 months (P = 0.001). No difference in weight and head circumference z‐score (P = 0.51 and P = 0.29, respectively), but an increase in height z‐score (P < 0.001) was observed over the evaluation period. There was a reduction in the incidence of upper respiratory tract infections, pneumonia and urinary tract infections over the follow‐up period. Conclusions NDT proved to be a viable treatment approach that can improve motor function and reduce the incidence of comorbidities in children with CZS, while having no harmful effects on their growth.

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“…ZIKV感染会对内耳造成广泛损害 [18] , CZS患儿可能存在听力丧失、吞咽困难、舌系带改变、神经精神运动和语言发育迟缓等语言和听力障碍 [19] . 此外, 严重运动障碍轴张力减退和阑尾张力增高在CZS患儿中也普遍存在 [20] . , 以及 BALB/c、C57BL/6等的小鼠垂直传播模型 [22] , 为ZIKV .…”

Section: 主要临床表现unclassified

Advances in congenital Zika syndrome and its pathogenesis

He¹,

Qin²,

Li³

2021

Chin. Sci. Bull.

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Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses OCL (Oilseeds, Crops, fats & Lipids) 26, 17 (2019); Advances and its diagnostic criteria in the study of the reduced porphyry ore deposits in China Acta Petrologicas Sinica 36, 967 (2020); Impact of elevated aspartate and alanine aminotransferase on metabolic syndrome and its components among adult people living in Ningxia, China Chronic Diseases and Translational Medicine 1, 124 (2015); Platelet proteomics and its advanced application for research of blood stasis syndrome and activated blood circulation herbs of Chinese medicine

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Classification of Congenital Zika Syndrome: Muscle Tone, Motor Type, Body Segments Affected, and Gross Motor Function

Cited by 9 publications

References 31 publications

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Urological outcomes in children with congenital Zika syndrome: The experience of a cohort in Campina Grande, Brazil

Effect of neurodevelopmental treatment in children with congenital Zika syndrome: A pilot study

Advances in congenital Zika syndrome and its pathogenesis

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