Classification of congenital melanocytic naevi and malignant transformation: a review of the literature

Subcutaneous Malignant Melanoma developing in Congenital Giant Naevus with Complete Spontaneous Regression of Superficial Dermo-Epidermal Part:A Case Report

“…In GCMN specimens, naevus cells are found to extend into deep layers of the dermis, sometimes around the lymphatic channels and vasculature, and even into the fascia or muscle [6]. It is very possible that benign naevocytes may spread via haematogenous or lymphatic routes [11].…”

“…These lesions are thought to be pre malignant and warrant early complete excision if possible. The risk of malignant transformation of all congenital naevi ranges from 0.05% to 10.7% with risk correlating with size and location [5][6][7][8]. Melanoma have been found more commonly in patients with garment naevus than giant naevus on limbs and/or head which accounts only 0.3% [5,9].…”

Woman with Giant Lesion in the Trunk

“…Malignant transformation into melanoma is the most common life-threatening complication and occurs in 5% to 8% of cases [2]. Half of these malignant transformations develop by age 5 [2]. Rarely, neurocutaneous melanocytosis, wich includes leptomeningeal melanosis and central nervous system proliferation of melanocytes may develop [3].…”

“…Malignant transformation into melanoma is the most common life-threatening complication and occurs in 5% to 8% of cases [2]. Half of these malignant transformations develop by age 5 [2].…”

“…Acceptable treatment options include close observation or surgical excision. Surgical management requires staged surgeries, skin grafting, or tissue expanders [1,2,5].…”