Classification of childhood medulloblastoma into WHO‐defined multiple subtypes based on textural analysis

2021

Front. Neuroinform.

Childhood medulloblastoma (MB) is a threatening malignant tumor affecting children all over the globe. It is believed to be the foremost common pediatric brain tumor causing death. Early and accurate classification of childhood MB and its classes are of great importance to help doctors choose the suitable treatment and observation plan, avoid tumor progression, and lower death rates. The current gold standard for diagnosing MB is the histopathology of biopsy samples. However, manual analysis of such images is complicated, costly, time-consuming, and highly dependent on the expertise and skills of pathologists, which might cause inaccurate results. This study aims to introduce a reliable computer-assisted pipeline called CoMB-Deep to automatically classify MB and its classes with high accuracy from histopathological images. This key challenge of the study is the lack of childhood MB datasets, especially its four categories (defined by the WHO) and the inadequate related studies. All relevant works were based on either deep learning (DL) or textural analysis feature extractions. Also, such studies employed distinct features to accomplish the classification procedure. Besides, most of them only extracted spatial features. Nevertheless, CoMB-Deep blends the advantages of textural analysis feature extraction techniques and DL approaches. The CoMB-Deep consists of a composite of DL techniques. Initially, it extracts deep spatial features from 10 convolutional neural networks (CNNs). It then performs a feature fusion step using discrete wavelet transform (DWT), a texture analysis method capable of reducing the dimension of fused features. Next, the CoMB-Deep explores the best combination of fused features, enhancing the performance of the classification process using two search strategies. Afterward, it employs two feature selection techniques on the fused feature sets selected in the previous step. A bi-directional long-short term memory (Bi-LSTM) network; a DL-based approach that is utilized for the classification phase. CoMB-Deep maintains two classification categories: binary category for distinguishing between the abnormal and normal cases and multi-class category to identify the subclasses of MB. The results of the CoMB-Deep for both classification categories prove that it is reliable. The results also indicate that the feature sets selected using both search strategies have enhanced the performance of Bi-LSTM compared to individual spatial deep features. CoMB-Deep is compared to related studies to verify its competitiveness, and this comparison confirmed its robustness and outperformance. Hence, CoMB-Deep can help pathologists perform accurate diagnoses, reduce misdiagnosis risks that could occur with manual diagnosis, accelerate the classification procedure, and decrease diagnosis costs.

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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CoMB-Deep: Composite Deep Learning-Based Pipeline for Classifying Childhood Medulloblastoma and Its Classes

2021

Front. Neuroinform.

“…Details of the dataset can be found in [ 33 ]. The dataset can be found at [ 34 ]. Samples of normal and MB subtypes’ images available in the dataset are shown in Figure 1 which are (a) normal, (b) classic, (c) desmoplastic, (d) large cell, and (e) nodular.…”

Section: Methodsmentioning

confidence: 99%

MB-AI-His: Histopathological Diagnosis of Pediatric Medulloblastoma and its Subtypes via AI

2021

Diagnostics

Medulloblastoma (MB) is a dangerous malignant pediatric brain tumor that could lead to death. It is considered the most common pediatric cancerous brain tumor. Precise and timely diagnosis of pediatric MB and its four subtypes (defined by the World Health Organization (WHO)) is essential to decide the appropriate follow-up plan and suitable treatments to prevent its progression and reduce mortality rates. Histopathology is the gold standard modality for the diagnosis of MB and its subtypes, but manual diagnosis via a pathologist is very complicated, needs excessive time, and is subjective to the pathologists’ expertise and skills, which may lead to variability in the diagnosis or misdiagnosis. The main purpose of the paper is to propose a time-efficient and reliable computer-aided diagnosis (CADx), namely MB-AI-His, for the automatic diagnosis of pediatric MB and its subtypes from histopathological images. The main challenge in this work is the lack of datasets available for the diagnosis of pediatric MB and its four subtypes and the limited related work. Related studies are based on either textural analysis or deep learning (DL) feature extraction methods. These studies used individual features to perform the classification task. However, MB-AI-His combines the benefits of DL techniques and textural analysis feature extraction methods through a cascaded manner. First, it uses three DL convolutional neural networks (CNNs), including DenseNet-201, MobileNet, and ResNet-50 CNNs to extract spatial DL features. Next, it extracts time-frequency features from the spatial DL features based on the discrete wavelet transform (DWT), which is a textural analysis method. Finally, MB-AI-His fuses the three spatial-time-frequency features generated from the three CNNs and DWT using the discrete cosine transform (DCT) and principal component analysis (PCA) to produce a time-efficient CADx system. MB-AI-His merges the privileges of different CNN architectures. MB-AI-His has a binary classification level for classifying among normal and abnormal MB images, and a multi-classification level to classify among the four subtypes of MB. The results of MB-AI-His show that it is accurate and reliable for both the binary and multi-class classification levels. It is also a time-efficient system as both the PCA and DCT methods have efficiently reduced the training execution time. The performance of MB-AI-His is compared with related CADx systems, and the comparison verified the powerfulness of MB-AI-His and its outperforming results. Therefore, it can support pathologists in the accurate and reliable diagnosis of MB and its subtypes from histopathological images. It can also reduce the time and cost of the diagnosis procedure which will correspondingly lead to lower death rates.

“…Principal component analysis (PCA), as well as multivariate analysis of variance (MANOVA) [32], were used for feature dimensionality reduction. Das et al [43] also experimented with various combinations of feature sets and fused four features to obtain a classification accuracy of 96.7% using PCA as a feature reduction method and a support vector machine (SVM) classifier. Only texture-based features were used in that study.…”

Section: Introductionmentioning

confidence: 99%

AI-Based Pipeline for Classifying Pediatric Medulloblastoma Using Histopathological and Textural Images

Zaghlool

2022

Life

Pediatric medulloblastomas (MBs) are the most common type of malignant brain tumors in children. They are among the most aggressive types of tumors due to their potential for metastasis. Although this disease was initially considered a single disease, pediatric MBs can be considerably heterogeneous. Current MB classification schemes are heavily reliant on histopathology. However, the classification of MB from histopathological images is a manual process that is expensive, time-consuming, and prone to error. Previous studies have classified MB subtypes using a single feature extraction method that was based on either deep learning or textural analysis. Here, we combine textural analysis with deep learning techniques to improve subtype identification using histopathological images from two medical centers. Three state-of-the-art deep learning models were trained with textural images created from two texture analysis methods in addition to the original histopathological images, enabling the proposed pipeline to benefit from both the spatial and textural information of the images. Using a relatively small number of features, we show that our automated pipeline can yield an increase in the accuracy of classification of pediatric MB compared with previously reported methods. A refined classification of pediatric MB subgroups may provide a powerful tool for individualized therapies and identification of children with increased risk of complications.