Classification of CEA‐related positivity in primary and metastatic malignant melanoma

Sanders, D. S. A.; Evans, Alan; Allen, Cynthia A.; Bryant, Frederick; Johnson, Gary D.; Hopkins, Jerry L.; Stocks, S. C.; Marsden, Jerry; Kerr, Michael A.

doi:10.1002/path.1711720409

Cited by 24 publications

(15 citation statements)

References 14 publications

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“…58 However, CEA can be shed by phospholipases from the cell surface through cleavage of its glycosylphosphatidylinositol-linkage, which causes the protein to be released in the circulation. This soluble CEA (sCEA) might therefore interfere with antibody based therapies.…”

Section: Other Bites In the Pipelinementioning

confidence: 99%

Bispecific antibodies for cancer therapy

Chames

Baty

2009

mAbs

281

137

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Section: Other Bites In the Pipelinementioning

confidence: 99%

Bispecific antibodies for cancer therapy

Chames

Baty

2009

mAbs

281

137

View full text Add to dashboard Cite

“…1 Expression of diVerent families of adhesion molecules has been reported previously in melanoma, [2][3][4] with major changes reported in the progression of normal melanocytes to benign naevi. Further dramatic changes also occur when cells progress from dysplastic naevi or radial growth phase melanoma to biologically late vertical growth phase primary melanoma.…”

mentioning

confidence: 99%

“…Further dramatic changes also occur when cells progress from dysplastic naevi or radial growth phase melanoma to biologically late vertical growth phase primary melanoma. [2][3][4][5][6] There is now compelling evidence to suggest that cadherins play a major role in epithelial cell-cell adhesion, with additional key roles recognised for cell phenotype, diVerentiation, epithelial/mesenchymal transformation, and invasion. [7][8][9] Loss of E-cadherin is associated with high grade morphology of tumours and there is a significant inverse relation between E-cadherin expression and survival in some tumours.…”

mentioning

confidence: 99%

Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours

Sanders¹,

Blessing²,

Hassan³

et al. 1999

Molecular Pathology

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119

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Aims-Compelling evidence from cell culture studies implicates cadherins in the neoplastic progression of melanocytic tumours but few reports describe the expression of cadherins and the related transmembrane proteins, catenins, in a full range of benign and malignant excised melanocytic tumours. Methods-Using immunohistochemistry and western blotting after tissue fractionation, the pattern of expression of cadherins/ catenins was studied in a range of surgically excised melanocytic tumours, from dysplastic naevi to stage III cutaneous metastatic malignant melanoma. Results-Appropriate membranous expression of E-cadherins and P-cadherins is seen in dysplastic naevocytes with an epithelioid phenotype and is largely maintained with malignant transformation to radial growth phase melanoma and primary vertical growth phase malignant melanoma.Loss of membranous E-cadherin is seen in a small number of vertical growth phase melanomas only when metastasis has occurred. However, there is a concomitant dramatic loss of membranous P-cadherin expression in all melanomas at the same stage. A minority of metastatic melanomas show de novo membranous N-cadherin expression in comparison with dysplastic naevi and primary melanoma. Membranous expression of the desmosomal cadherin, desmoglein, was not seen in any tumour studied. Frequently, catenin is aberrantly produced in the cytoplasm of cells in dysplastic naevi and metastatic malignant melanoma, with an implied compromise to adhesive function. Furthermore, membranous catenin expression was not seen in any of the 70 melanocytic tumours studied, implying obligatory transmembrane binding of cadherins to catenin for maintenance of adhesive function. Conclusions-The most important alterations in membranous cadherin and catenin expression are seen late in the biological progression of melanocytic tumours at the stage of "in transit" or regional lymph node metastasis, with implications for tumour growth, invasion, and dissemination. (J Clin Pathol: Mol Pathol 1999;52:151-157)

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“…However, in independent studies conducted by Sanders et al [33] and Ravindranath et al [34] they found that anti cEA specific mAbs were not reactive with malignant melanoma. By contrast, Selby et al [35] found cEA immunoreactivity with a polyclonal antibody in a significant number of malignant melanoma cases.…”

Section: The Importance Of Monoclonal Antibodies Specificity For Cea mentioning

confidence: 99%

The expression and modulation of CEACAM1 and tumor cell transformation

Fiori¹,

Magnani

Cianfriglia

2012

Annali Dell'Istituto Superiore Di Sanità

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Abstract.Background. In this review, we focus our discussion on one class of carcinoembryonic antigen-related cell adhesion molecules, carcinoembryonic antigen-related cell adhesion molecules 1 (cEAcAM1). This has been observed in several malignant transformations to be subjected to complex mechanisms of modulation and dysregulation. aims. Restoration of cEAcAM1 expression in tumor cell lines often abolishes their oncogenicity in vivo, and therefore, this adhesion molecule has been regarded as a tumor suppressor. In contrast, de novo expression of cEAcAM1 is found with the progression of malignancy and metastatic spread in a large array of cancer tissues which include melanoma, Non Small cell Lung carcinoma (NScLc) as well as bladder, prostate, thyroid, breast, colon and gastric carcinomas. Discussion.We report and discuss the most significant findings confirming at immunohistochemical and clinical level the correlation between poor prognosis and expression of cEAcAM1 on the cell surface of tumors.Key words: cEAcAM1, cancer, dysregulation, NScLc, melanoma, poor prognosis. Riassunto (Espressione e modulazione cellulare di CEaCaM1 e trasformazione tumorale).In questo articolo abbiamo focalizzato il nostro interesse su di una classe di molecole di adesione e più in particolare sul cEAcAM1 che in diversi studi è stato osservato essere coinvolto nella trasformazione tumorale attraverso complessi meccanismi di modulazione e di alterata regolazione. Obiettivo. L'espressione di cEAcAM1 risulta spesso associata con l'abolizione della oncogenicità di linee cellulari trasformate e pertanto questa molecola di adesione è stata considerata alla stregua di un immunosoppressore tumorale. Discussione. In contrasto con questa osservazione, in molti casi l'espressione de novo di cEAcAM1 risulta essere associata con la progressione tumorale e la metastatizzazione di diverse forme di cancro che includono il melanoma, il carcinoma polmonare a non piccole cellule, il carcinoma della vescica, della prostata, mammario, tiroideo e del carcinoma gastrico e del colon. In questo articolo riportiamo i dati più significativi della letteratura corrente che dimostrano attraverso studi immunoistochimici e clinici una stretta correlazione fra prognosi infauste ed espressione del cEAcAM1 sulla superficie di cellule tumorali.Parole chiave: cEAcAM1, cancro, alterata regolazione, NScLc, melanoma, prognosi infausta.

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Classification of CEA‐related positivity in primary and metastatic malignant melanoma

Cited by 24 publications

References 14 publications

Bispecific antibodies for cancer therapy

Bispecific antibodies for cancer therapy

Alterations in cadherin and catenin expression during the biological progression of melanocytic tumours

The expression and modulation of CEACAM1 and tumor cell transformation

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