Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984–2005

Lannering, Birgitta; Sandström, Per-Erik; Holm, Stefan; Lundgren, Johan; Pfeifer, Susan; Samuelsson, Ulf; Strömberg, Bo; Gustafsson, Göran

doi:10.1111/j.1651-2227.2009.01417.x

Cited by 104 publications

(121 citation statements)

References 26 publications

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“…In our study we did not find a difference in survival between the TYA age group and children aged 5-9 years. We did however observe a doubling of the risk of death for those aged under 5 years, consistent with other studies (3,5,(15)(16)(17)(18)(19)31) due to treatment strategies for infants and young children that defer or avoid radiation (7).…”

Section: Discussionsupporting

confidence: 91%

“…Central nervous system (CNS) tumours are the second most common site of neoplasms diagnosed in children, accounting for approximately one quarter of all childhood cancers (0-14 years), (1) and 14% of tumours diagnosed in teenagers and young adults (TYA) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24) years) (2). They are the most common cause of cancer related death in children and TYA (1,2).…”

Section: Introductionmentioning

confidence: 99%

“…Population-based studies which have analysed survival rates separately for medulloblastoma and CNS PNET have shown that children diagnosed with medulloblastoma have better survival outcomes than those with CNS PNET (5-year survival rates range between 58-69% for medulloblastoma vs. 27-47% for CNS PNET) (3,(15)(16)(17)(18). The incidence of childhood CNS embryonal tumours increased in Europe between 1978 and 1997 (19).…”

Section: Introductionmentioning

confidence: 99%

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Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Fairley

Picton

McNally

et al. 2016

European Journal of Cancer

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Fairley

Picton

McNally

et al. 2016

European Journal of Cancer

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“…Diagnostic information of the Swedish (Lannering et al, 2009) and most of the Danish cases (Thorsteinsson et al, 2005;RaaschouNielsen et al, 2006) was reabstracted and recoded on the basis of information from individual medical records. In Finland, pathology reports were consulted to classify glia cell tumours more specifically than the data available from the Finnish Cancer Registry.…”

Section: Methodsmentioning

confidence: 99%

Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth

et al. 2010

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BACKGROUND: An infective, mostly viral basis has been found in different human cancers. To test the hypothesis of a possible infectious aetiology for central nervous system (CNS) tumours in children, we investigated the associations with proxy measures of exposure to infectious disease. METHODS: In a large case -control study nested in the populations of Denmark, Norway, Sweden, and Finland of 4.4 million children, we studied the association of birth order and seasonal variation of birth with subsequent risk for CNS tumours. We identified 3983 children from the national cancer registries, and information on exposure was obtained from the high-quality national administrative health registries. We investigated the association between childcare attendance during the first 2 years of life and the risk for CNS tumours in a subset of Danish children with CNS tumours, using information from the Danish Childcare database. RESULTS: We observed no association between birth order and risk of CNS tumours overall (odds ratio (OR) for second born or later born vs first born, 1.03; 95% confidence interval (CI), 0.96 -1.10) or by histological subgroup, and children with CNS tumours did not show a seasonal variation of birth that was distinct from that of the background population. Childcare attendance compared with homecare showed a slightly increased OR (1.29; 95% CI, 0.90 -1.86) for CNS tumours, with the highest risk observed in children attending a crèche. The strongest association was observed for embryonal CNS tumours. We found no effect of age at enrolment or duration of enrolment in childcare. CONCLUSION: These results do not support the hypothesis that the burden of exposure to infectious disease in early childhood has an important role in the aetiology of paediatric CNS tumours.

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“…Another study in Italy showed the incidence of brain tumour was 40 per million children per year 3 . In Sweden a study showed annual incidence of childhood brain tumour was 42 per million children of less than 15 years 4 . Another study in Japan showed age adjusted annual incidence rate of primary intracranial tumour was 36.1 per million children 5 .…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of Brain Tumour in Children

Sharmin

Begum

Khatoon³

2017

J Shaheed Suhrawardy Med Coll

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Background: This study was designed to evaluate the clinical profile and location of brain tumours in children so that brain tumour cases could be diagnosed and managed earlier. Materials and Methods: This cross sectional study was carried out from April 2011 to April 2012. A total 50 clinically suspected cases of brain tumour and supported by MRI were enrolled in this study. Results: Brain tumour of children was predominant in male where male to female ratio was almost 1.9:1. Supratentorial and Infratentorial brain tumour were found in 36% and 64% cases respectively in children. According to MRI findings in the supratentorial location, craniopharyngioma were commonest (50%) followed by cerebral astrocytoma (22.2%). In the infratentorial region, medulloblastoma was observed in (40.6%), followed by cerebellar astrocytoma (31.3%). Vertigo, weakness of limbs were found in 46.9% and 87.5% cases respectively in infratentorial group which were significantly (p<0.05) higher than supratentorial group. Growth failure and behavioral change were found in 16.7% and 22.2% cases respectively in supratentorial which were significantly (p<0.05) higher than infratentorial group. Papilloedema, reduced muscle power, increased muscle tone, exaggerated deep reflexes, clonus, gait disturbance and cerebellar signs were significantly (p<0.05) higher in infratentorial group. Conclusion: Craniopharyngioma and medulloblastoma were more common findings in MRI evaluation in the supratentorial and infratentorial location respectively. Growth failure and behavioral change were found higher in supratentorial than infratentorial group. Vertigo, weakness of limbs, papilloedema, reduced muscle power, increased muscle tone, exaggerated deep reflexes, clonus, gait disturbance and cerebellar signs were higher in infratentorial group. [J Shaheed Suhrawardy Med Coll 2016;8(1): 08-12]

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Classification, incidence and survival analyses of children with CNS tumours diagnosed in Sweden 1984–2005

Abstract: The mean annual incidence of children with CNS tumours was 4.2/100,000 and has not increased during the study period. Survival rate for brain tumours at 10 years follow-up was 72%.

Cited by 104 publications

References 26 publications

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Incidence and survival of children and young people with central nervous system embryonal tumours in the North of England, 1990–2013

Infectious exposure in the first years of life and risk of central nervous system tumours in children: analysis of birth order, childcare attendance and seasonality of birth

Clinical Profile of Brain Tumour in Children

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