Classification and pathology of primary progressive aphasia

Harris, Jennifer; Gall, Claire; Thompson, James C.; Richardson, Anna; Neary, David; Plessis, Daniel du; Pal, Piyali; Mann, David; Snowden, Julie S.; Jones, Matthew

doi:10.1212/01.wnl.0000436070.28137.7b

Cited by 203 publications

(203 citation statements)

References 32 publications

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“…4 Behavioural variant (bv) of FTD was diagnosed by revised diagnostic criteria reported by the International bvFTD Criteria Consortium 5 and language variant of FTD was diagnosed by latest published criteria. 6 Patients with VaD were diagnosed according to the criteria of the NINDS-AIREN (National Institute of Neurological Disorders and Stroke/Association Internationale pour la Recherche et l'Enseignement en Neurosciences). 18 In this study, we reviewed the medical records of eligible subjects and collected data including age, sex, education level, Mini-Mental State Examination score, Clinical Dementia Rating scale score, molecular imaging report including the standardised uptake value ratio (SUVR) of 11 C-PIB PET, and the pre-and post-imaging diagnoses.…”

Section: Methodsmentioning

confidence: 99%

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Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Shea

et al. 2016

Hong Kong Med J

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Section: Methodsmentioning

confidence: 99%

“…The pattern of 18 F-FDG PET hypometabolism that is suggestive of each subtype of dementia is as follows 6,12,19 : (1) …”

Section: Methodsmentioning

confidence: 99%

Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Shea

et al. 2016

Hong Kong Med J

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“…However, some studies have been published concerning the usefulness of the classification and these criteria, with controversial results [5,6,7]. Positron emission tomography imaging with 18 F-fluorodeoxyglucose (FDG-PET) aids in the topographic diagnosis, where hypometabolism is associated with neurodegeneration [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the New Consensus Criteria for the Diagnosis of Primary Progressive Aphasia Using Fluorodeoxyglucose Positron Emission Tomography

Matías‐Guiu

Cabrera‐Martín

García-Ramos

et al. 2014

Dement Geriatr Cogn Disord

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Background: New consensus criteria have been proposed to classify primary progressive aphasia (PPA) into three variants: agrammatic, semantic, and logopenic. Some studies have subsequently addressed the usefulness of these criteria, with controversial results. We aimed to determine the correlation between the clinical diagnosis according to the new criteria and brain topography in ¹⁸F-fluorodeoxyglucose positron emission tomography (FDG-PET). Methods: Patients meeting the PPA criteria were prospectively recruited in a single center during a period of 18 months. They were clinically classified according to the new criteria and underwent FDG-PET. The cerebral metabolism of each patient was compared to a healthy control group using statistical parametric mapping. The expected variant according to the analysis of PET imaging was compared with the clinical diagnosis using the consensus criteria. Results: 32 patients were included. 90% of them fulfilled the consensus criteria and could be classified into one of the three clinical variants. The correlation with the cerebral metabolism was high: the kappa index was 0.91 in the agrammatic variant, 0.71 in the semantic variant, and 0.74 in the logopenic variant. Conclusions: A high correlation with the diagnosis obtained using FDG-PET was found. However, an overdiagnosis of the logopenic variant was observed. These results support the use of the new criteria, but some modifications or complementary studies may still be necessary.

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“…The sv-PPA is strongly associated with microscopic inclusions of transactive response DNAbinding protein of 43 kDa (TDP-43), the nfv-PPA with tau inclusions, and a large proportion of lv-PPA cases with Alzheimer's pathology. [28][29][30] Despite these seemingly clear-cut associations, a number of clinical and pathological series demonstrate that some cases show unexpected pathological associations and not all PPA cases can be classifiable into one of the three variants. This raises issues about the biological validity and applicability of this tripartite approach.…”

Section: The Inception Of the International Consensus Criteriamentioning

confidence: 99%

Primary progressive aphasia: conceptual evolution and challenges

Leyton¹,

Ballard²

2016

NAN

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Abstract:Since the modern description of primary progressive aphasia (PPA) more than 30 years ago, the interest in neurodegenerative conditions that selectively target the language network has grown exponentially. Fueled by advances in neuroimaging and biomarkers, progress in the field has brought new insights into clinical categorization, neural correlates of language, and pathological mechanisms of progression in PPA. Of relevance, the inception of logopenic progressive aphasia as an atypical presentation of Alzheimer's disease and the formalization of the international diagnostic criteria and classification of PPA represent milestones in the field. Paradoxically, those advances have also brought controversy and challenges. The application of the current classification in cases with mixed or very mild language deficits is still challenging, while the accurate pathological prediction at the individual level remains elusive. In addition, it is more evident now that nonlanguage deficits, including other cognitive and motor deficits, can appear early on and potentially assist in the differential diagnosis. From a historical perspective, this review addresses the conceptual evolution of PPA and the contribution that clinical refinements, cognitive neuropsychology, and pathology have made to the field.

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Classification and pathology of primary progressive aphasia

Cited by 203 publications

References 32 publications

Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Impact of 18FDG PET and 11C-PIB PET brain imaging on the diagnosis of Alzheimer’s disease and other dementias in a regional memory clinic in Hong Kong

Evaluation of the New Consensus Criteria for the Diagnosis of Primary Progressive Aphasia Using Fluorodeoxyglucose Positron Emission Tomography

Primary progressive aphasia: conceptual evolution and challenges

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