Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening
Matteo Gentili,
Rebecca J. Carlson,
Bingxu Liu
et al.
Abstract:STING is an innate immune sensor that traffics across many cellular compartments to carry out its function of detecting cyclic di-nucleotides and triggering defense processes. Mutations in factors that regulate this process are often linked to STING-dependent human inflammatory disorders. To systematically identify factors involved in STING trafficking, we performed a genome-wide optical pooled screen and examined the impact of genetic perturbations on intracellular STING localization. Based on subcellular ima… Show more
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