Classificação da Organização Mundial da Saúde para os tumores dos tecidos hematopoético e linfoide, 4a edição, 2008 - principais modificações introduzidas em relação à 3a edição, 2001

Zerbini, Maria Cláudia Nogueira; Soares, Fernando Augusto; Velloso, Elvira Deolinda Rodrigues Pereira; Chaufaille, Maria de Lourdes l. F.; Paes, Roberto Pinto

doi:10.1590/s0104-42302011000100019

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…В 25-30 % случаев B-ОЛЛ у детей [7] и в 2-10 % -у взрослых наблюдается гиперплоидия [8,9], при которой в ядрах лейкозных клеток содержится 51-67 хромосом вместо 46, как это должно быть в норме. При T-ОЛЛ гиперплоидия встречается крайне редко.…”

Section: клиническая онкогематологияunclassified

Cytogenetic and Molecular Genetic Prognostic Factors of Acute Lymphoblastic Leukemias

Misyurin¹

2017

Clin onclohematol

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Section: клиническая онкогематологияunclassified

Cytogenetic and Molecular Genetic Prognostic Factors of Acute Lymphoblastic Leukemias

Misyurin¹

2017

Clin onclohematol

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“…The diagnosis of this neoplasia is confirmed by the presence of 25% or more lymphoblasts in the total BM nucleated cells, according to the classification by the World Health Organization (WHO) (Figure 1B). However, if a blast level lower than 20% is encountered in the marrow, other exams must be performed to confirm diagnosis (22) .…”

Section: Morphology Of B Lymphoid Cellsmentioning

confidence: 99%

“…Out of concern for incorporating genetic alterations, WHO presented a group of clinical, morphological, immunophenotypic and genetic parameters used by pathologists, hematologists and oncologists to characterize malignant neoplasias (22,36) . Upon meeting these criteria for B-ALL, patients have been treated according to specific protocols.…”

Section: Immunophenotypic Analysis Of B Lymphoid Precursor Cellsmentioning

confidence: 99%

The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts

Wohlfahrt¹,

Hannel²,

Oliveira³

et al. 2015

Jornal Brasileiro De Patologia E Medicina Laboratorial

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Hematogones are normal B-lineage lymphoid precursors in the bone marrow. B lymphoblasts are immature neoplastic cells present in patients with precursor B-cell acute lymphoblastic leukemia (B-ALL). Hematogones and B lymphoblasts share characteristics, such as morphological similarity often indistinct and expression of the same antigens in immunophenotypic analysis. Increased numbers of hematogones in patients with B-ALL during regeneration of bone marrow after treatment for leukemia, in cases of disease relapse or marrow transplantation, may be subject to questions about the nature and prognosis of this immature cell. This article presents information about the morphological and immunophenotypic characteristics of B lymphoid precursors and verifies the relevance of immunophenotyping by flow cytometry (FC) in the distinction between those cells. This differentiation is essential to establish a correct prognosis and assist in medical decision about the most appropriate therapeutic scheme.

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Frequency of p190 and p210 BCR-ABL rearrangements and survival in Brazilian adult patients with acute lymphoblastic leukemia

Azevedo

Júnior

Vasconcelos

et al. 2014

Revista Brasileira de Hematologia e Hemoterapia

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ObjectiveThis study investigated the occurrence of the p190 and p210 breakpoint cluster region-Abelson (BCR-ABL) rearrangements in adults with acute lymphoblastic leukemia and possible associations with clinical and laboratory characteristics and survival.MethodsForty-one over 18-year-old patients with acute lymphoblastic leukemia of both genders followed-up between January 2008 and May 2012 were included in this study. Clinical and laboratory data were obtained from the medical charts of the patients. Reverse transcription polymerase chain reaction (RT-PCR) using specific primers was employed to identify molecular rearrangements.ResultsAt diagnosis, the median age was 33 years, and there was a predominance of males (61%). The most common immunophenotype was B lineage (76%). BCR-ABL rearrangements was detected in 14 (34%) patients with the following distribution: p190 (28%), p210 (50%) and double positive (22%). Overall survival of patients with a mean/median of 331/246 days of follow up was 39%, respectively, negative BCR-ABL (44%) and positive BCR-ABL (28%).ConclusionThese results confirm the high frequency of BCR-ABL rearrangements and the low survival rate of adult Brazilian patients with acute lymphoblastic leukemia.

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Classificação da Organização Mundial da Saúde para os tumores dos tecidos hematopoético e linfoide, 4a edição, 2008 - principais modificações introduzidas em relação à 3a edição, 2001

Cited by 5 publications

References 7 publications

Cytogenetic and Molecular Genetic Prognostic Factors of Acute Lymphoblastic Leukemias

Cytogenetic and Molecular Genetic Prognostic Factors of Acute Lymphoblastic Leukemias

The importance of immunophenotyping by flow cytometry in distinction between hematogones and B lymphoblasts

Frequency of p190 and p210 BCR-ABL rearrangements and survival in Brazilian adult patients with acute lymphoblastic leukemia

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