Classics in Chemical Neuroscience: Methylphenidate

Wenthur, Cody J.

doi:10.1021/acschemneuro.6b00199

Cited by 48 publications

(33 citation statements)

References 144 publications

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“… Acinetobacter genus is characterized as phenol-degrading microorganisms which can use it as sole energy and carbon source [45]. Some strains of this genus are known to have a role in the biodegradation of a wide number of different pollutants, such as biphenyl and chlorinated biphenyl, amino acids (aniline), phenol, benzoate, crude oil, acetonitrile, and in the removal of phosphate or heavy metals [46, 47]. It has also been reported that certain Acinetobacter strains can utilize biphenyls including chlorinated biphenyls.…”

Section: Resultsmentioning

confidence: 99%

Isolation and characterization of bacteria from activated sludge capable of degrading 17α-ethinylestradiol, a contaminant of high environmental concern

2021

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The compound 17α-ethinylestradiol (EE2) is a synthetic oestrogen which is classified as a group 1 carcinogen by the World Health Organization. Together with other endocrine disruptor compounds, EE2 has been included in the surface water Watch List by the European Commission, since it causes severe adverse effects in ecosystems. Thus, it became a high priority to find or improve processes such as biodegradation of EE2 to completely remove this drug from the wastewater treatment plants (WWTPs). The present study aimed at the isolation of bacteria capable of degrading EE2 using environmental samples, namely a sludge from the Faro Northwest WWTP. Four isolates with ability to grow in the presence of 50 mg l−1 EE2 were obtained. The analysis of 16SrRNA gene sequences identified the isolated bacteria as Acinetobacter bouvetii, Acinetobacter kookii, Pantoea agglomerans and Shinella zoogloeoides . The results of biodegradation assays showed that Acinetobacter bouvetii , Acinetobacter kookii , Pantoea agglomerans and Shinella zoogloeoides were able to degrade 47±4 %, 55±3 %, 64±4% and 35±4 %, respectively of 13 mg l−1 EE2 after 168 h at 28 °C. To the best of our knowledge, these bacterial isolates were identified as EE2 degraders for the first time. In a preliminary experiment on the identification of metabolic products resulting from EE2 degradation products such as estrone (E1), γ-lactone compounds, 2-pentanedioic acid and 2-butenedioic acid an intermediate metabolite of the TCA cycle, were detected.

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Section: Resultsmentioning

confidence: 99%

Isolation and characterization of bacteria from activated sludge capable of degrading 17α-ethinylestradiol, a contaminant of high environmental concern

2021

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“…Rather than in para position, the CF3 group was placed in ortho or in meta position on compounds 1a and 1b, respectively. In compounds 1c and 1d, an additional substituent in ortho position was introduced to the parent compound (22).…”

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confidence: 99%

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

et al. 2020

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Enteroviruses (EV) are a group of positive-strand RNA (+RNA) viruses that include many important human pathogens (e.g. poliovirus, coxsackievirus, echovirus, numbered enteroviruses and rhinoviruses). Fluoxetine was identified in drug repurposing screens as potent inhibitor of enterovirus B and enterovirus D replication. In this paper we are reporting the synthesis and the antiviral effect of a series of fluoxetine analogues. The results obtained offer a preliminary insight into the structure-activity relationship of its chemical scaffold and confirm the importance of the chiral configuration. We identified a racemic fluoxetine analogue, 2b, which showed a similar antiviral activity compared to (S)-fluoxetine. Investigating the stereochemistry of 2b revealed that the S-enantiomer exerts potent antiviral activity and increased the antiviral spectrum compared to the racemic mixture of 2b. In line with the observed antiviral effect, the S-enantiomer displayed a dose-dependent shift in the melting temperature in thermal shift assay, indicative for direct binding to the recombinant 2C protein.

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“…The molecule also has two stereo-centres that generate 4 possible configurational isomers. These isomers are divided into two pairs of enantiomers, erythro (2R, 2'R, and 2S, 2'S) and threo (2R, 2'S, and 2S, 2'R) [36]. MPH is soluble in ethyl acetate, ether, etc., and insoluble in water [37].…”

Section: H Bond Acceptors and 4 Rotatable Bonds And Fully Complies Withmentioning

confidence: 99%

Review on analytical methods for quantification of ADHD drugs in human biological samples

Sundari¹,

Amuthalakshmi²,

Nalini³

2020

Reviews in Analytical Chemistry

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Attention deficit hyperactivity disorder (ADHD) is a common neuro-developmental disorder. The symptoms of ADHD include difficulty in attention, memory and impulse control. Many pharmaceutical formulations (stimulants and non-stimulants) are available on the market to treat ADHD symptoms. The most commonly used drugs for treatment are amphetamine, methylphenidate, atomoxetine, bupropion, guanfacine and clonidine. In the field of pharmaceuticals, bioanalysis is an important tool used for the quantification of drugs and their metabolites present in biological samples using various analytical methods. Although a number of analytical methods were reported for the quantification of these drugs in biological samples of experimental animals, due to species differences, it is important to develop analytical methods to quantify these drugs in human biological samples to aid forensic and pharmacokinetic studies. In this review, we compile the bio-analytical methods such as spectrophotometry, spectrofluorimetry, mass spectrometry, electrophoresis, liquid chromatography and gas chromatography used for the quantification of ADHD drugs in human biological samples such as blood, plasma, serum, oral fluids, sweat, hair and urine based on earlier published articles from various journals.

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Classics in Chemical Neuroscience: Methylphenidate

Cited by 48 publications

References 144 publications

Isolation and characterization of bacteria from activated sludge capable of degrading 17α-ethinylestradiol, a contaminant of high environmental concern

Isolation and characterization of bacteria from activated sludge capable of degrading 17α-ethinylestradiol, a contaminant of high environmental concern

Synthesis and antiviral effect of novel fluoxetine analogues as enterovirus 2C inhibitors

Review on analytical methods for quantification of ADHD drugs in human biological samples

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