Classical Kaposi sarcoma

Brenner, Baruch; Weissmann-Brenner, Alina; Rakowsky, Erica; Weltfriend, Sara; Fenig, Eyal; Friedman‐Birnbaum, Rachel; Sulkes, Aarón; Linn, Shai

doi:10.1002/cncr.10907

Cited by 53 publications

(7 citation statements)

References 81 publications

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“…Furthermore, the proportion of patients with systemic involvement in our cohort was slightly higher to that seen in other series of patients with CKS, ranging from 4% to 10% of patients. [10,36]. Also, in this work, we found that men were more likely to have advanced stage at diagnosis.…”

Section: Discussionsupporting

confidence: 62%

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Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

et al. 2011

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BackgroundClassic Kaposi's sarcoma (CKS) is a rare disease likely associated with human herpes virus 8 (HHV-8) infection, and occurs predominantly in Jewish, Mediterranean and middle eastern men .There is a dearth of data in Moroccan patients with CKS regarding epidemiology, clinical characteristics and outcomes. This report examines a cohort of patients with CKS evaluated at the national institute of oncology over 11-year period.MethodsA retrospective analysis of patients referred to the national institute of oncology with classical Kaposi sarcoma, between January 1998 and February 2008, was performed. Reviewed information included demographics, clinical and pathological staging, death or last follow-up.ResultsDuring the study period, 56 patients with a diagnosis of CKS have been referred to our hospital. There were 11(19,7%) females and 45 (80,3%) males (male-to-female ratio: 4:1). Mean age at diagnosis was 61,7 ± 15 (range: 15- 86 years). Nodules and/or plaques were the most frequent type of lesion. The most common location was the lower limbs, particularly the distal lower extremity (90%). In addition to skin involvement, visceral spread was evident in 9 cases. The most common visceral involvement sites were lymph nodes (44%), lung (22%), and gastrointestinal tract (22%). Associated lymphoedema was seen in 24 (42%) of the patients. There were 18 stage I patients (32,14%), 8: stage II (14,28%), 21 stage III(37,5%) and 9 stage IV (16,07%). A second primary malignancy was diagnosed in 6 cases (10,7%), none of the reticuloendothelial system.With a median follow-up of 45 months, 38 (67,8) patients are alive, of whom 25 (65,78%) patients with stable disease, five with progressive disease currently under systemic chemotherapy and 8(21,05%) are alive and free of disease, over a mean interval of 5 years.ConclusionThis is the largest reported series in our context. In Morocco, CKS exhibits some special characteristics including a disseminated skin disease at diagnosis especially in men, a more common visceral or lymph node involvement and a less frequent association with second malignancies.

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Section: Discussionsupporting

confidence: 62%

“…Prognosis appears to correlate with the degree of immunosuppression and older age among classic KS patients[35,36]. Localized nodular KS has the best prognosis, with few deaths directly attributable to KS.…”

Section: Discussionmentioning

confidence: 99%

Classic Kaposi's sarcoma in morocco: clinico -epidemiological study at the national institute of oncology

et al. 2011

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“…Brenner et al (58) retrospectively analyzed all of the classic KS patients (a total of 248) treated in two hospitals in northern Israel and Tel Aviv between 1960 and 1995. Using progression-free survival as the end point of disease, univariate and multivariate analyses showed that increasing age at KS diagnosis was prognostic of increasing disease progression and that immunosuppression (from steroid treatment or renal failure associated with organ transplantation) predicted dissemination.…”

Section: Classic Ksmentioning

confidence: 99%

Molecular Genetics of Kaposi's Sarcoma-Associated Herpesvirus (Human Herpesvirus 8) Epidemiology and Pathogenesis

Dourmishev

Palmeri

et al. 2003

Microbiol Mol Biol Rev

309

367

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Kaposi's sarcoma had been recognized as unique human cancer for a century before it manifested as an AIDS-defining illness with a suspected infectious etiology. The discovery of Kaposi's sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus-8, in 1994 by using representational difference analysis, a subtractive method previously employed for cloning differences in human genomic DNA, was a fitting harbinger for the powerful bioinformatic approaches since employed to understand its pathogenesis in KS. Indeed, the discovery of KSHV was rapidly followed by publication of its complete sequence, which revealed that the virus had coopted a wide armamentarium of human genes; in the short time since then, the functions of many of these viral gene variants in cell growth control, signaling apoptosis, angiogenesis, and immunomodulation have been characterized. This critical literature review explores the pathogenic potential of these genes within the framework of current knowledge of the basic herpesvirology of KSHV, including the relationships between viral genotypic variation and the four clinicoepidemiologic forms of Kaposi's sarcoma, current viral detection methods and their utility, primary infection by KSHV, tissue culture and animal models of latent- and lytic-cycle gene expression and pathogenesis, and viral reactivation from latency. Recent advances in models of de novo endothelial infection, microarray analyses of the host response to infection, receptor identification, and cloning of full-length, infectious KSHV genomic DNA promise to reveal key molecular mechanisms of the candidate pathogeneic genes when expressed in the context of viral infection

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“…Mucosal membranes are rarely involved in CKS but visceral involvement is common. 7,8 Liver, heart, lymph nodes, spleen, lung and bone marrow involvements are reported in different cases. 9 Gastrointestinal system involvement, especially gastric involvement is also reported and it often causes GI bleeding.…”

Section: Discussionmentioning

confidence: 99%