Classical DC2 subsets and monocyte‐derived DC: Delineating the developmental and functional relationship

Backer, Ronald A.; Probst, Hans; Clausen, Björn E.

doi:10.1002/eji.202149548

Cited by 11 publications

(8 citation statements)

References 150 publications

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“…Similar to IRF4 in cDCs, moDCs have demonstrated dual roles by activating anti-tumoral CD8 + T cells ( 41 ) and suppressing respiratory CD8 + T cell memory in viral immunity ( 42 ). Moreover, moDCs or infDCs and cDC2s express CD11b during inflammation, making these cell populations phenotypically difficult to distinguish ( 19 ).…”

Section: Subsets and Their Role In Immunogenicitymentioning

confidence: 99%

Dendritic cells: the yin and yang in disease progression

Jiménez-Cortegana,

Palomares,

Alba

et al. 2024

Front. Immunol.

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Dendritic cells (DCs) are antigen presenting cells that link innate and adaptive immunity. DCs have been historically considered as the most effective and potent cell population to capture, process and present antigens to activate naïve T cells and originate favorable immune responses in many diseases, such as cancer. However, in the last decades, it has been observed that DCs not only promote beneficial responses, but also drive the initiation and progression of some pathologies, including inflammatory bowel disease (IBD). In line with those notions, different therapeutic approaches have been tested to enhance or impair the concentration and role of the different DC subsets. The blockade of inhibitory pathways to promote DCs or DC-based vaccines have been successfully assessed in cancer, whereas the targeting of DCs to inhibit their functionality has proved to be favorable in IBD. In this review, we (a) described the general role of DCs, (b) explained the DC subsets and their role in immunogenicity, (c) analyzed the role of DCs in cancer and therapeutic approaches to promote immunogenic DCs and (d) analyzed the role of DCs in IBD and therapeutic approaches to reduced DC-induced inflammation. Therefore, we aimed to highlight the “yin-yang” role of DCs to improve the understand of this type of cells in disease progression.

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Section: Subsets and Their Role In Immunogenicitymentioning

confidence: 99%

Dendritic cells: the yin and yang in disease progression

Jiménez-Cortegana,

Palomares,

Alba

et al. 2024

Front. Immunol.

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“…The exact function of moDC in vivo is still unclear. They might be less migratory than cDCs and rather function at the infection site, produce higher level of inflammatory cytokines and chemokines, and orchestrate inflammatory response locally (Guilliams and van de Laar, 2015;Backer et al, 2023). In this review, we mainly focus our discussion on the response, behavior and function of cDCs and pDCs after the pathogen invasion.…”

Section: Subsetsmentioning

confidence: 99%

Insights into dendritic cell maturation during infection with application of advanced imaging techniques

Xiao

Xia²

2023

Front. Cell. Infect. Microbiol.

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Dendritic cells (DCs) are crucial for the initiation and regulation of adaptive immune responses. When encountering immune stimulus such as bacterial and viral infection, parasite invasion and dead cell debris, DCs capture antigens, mature, acquire immunostimulatory activity and transmit the immune information to naïve T cells. Then activated cytotoxic CD8+ T cells directly kill the infected cells, while CD4+ T helper cells release cytokines to aid the activity of other immune cells, and help B cells produce antibodies. Thus, detailed insights into the DC maturation process are necessary for us to understand the working principle of immune system, and develop new medical treatments for infection, cancer and autoimmune disease. This review summarizes the DC maturation process, including environment sensing and antigen sampling by resting DCs, antigen processing and presentation on the cell surface, DC migration, DC-T cell interaction and T cell activation. Application of advanced imaging modalities allows visualization of subcellular and molecular processes in a super-high resolution. The spatiotemporal tracking of DCs position and migration reveals dynamics of DC behavior during infection, shedding novel lights on DC biology.

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“…The latter can be further subclassified into two main subsets -cDC1 and cDC2 [11][12][13][14] . Additional subclassifications of cDC1 and cDC2 that are shaped by the microenvironment are the object of ongoing research 14,[17][18][19] . Moreover, DCs can also derive from monocytes (moDCs) in inflammatory settings.…”

Section: Introductionmentioning

confidence: 99%

Ebola virus infection of Flt3-dependent, conventional dendritic cells and antigen cross-presentation leads to high levels of T-cell activation

Niemetz,

Bodmer,

Olal

et al. 2024

Preprint

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Severe Ebola virus disease (EVD) is characterized by excess, dysregulated T-cell activation and high levels of inflammation. Previous studies have described that in vitro EBOV infection of monocyte-derived DCs (moDCs) inhibits DC maturation resulting in suppression of T cell activation. However, it is unknown how other DC subsets distinct from moDCs respond to EBOV infection. To better understand how DCs initiate T cell activation during EBOV infection, we assessed the response of FMS-like tyrosine kinase 3 (Flt3)-dependent, conventional mouse DCs (cDCs) to EBOV infection, and developed a DC-T cell co-culture system utilizing a recombinant EBOV expressing the model antigen ovalbumin. Our findings suggested that, in contrast to moDCs, cDC2 and cDC1 were poorly infected with EBOV, although both infected and bystander cDCs displayed high levels of activation. DCs were able to activate CD8 T cells via cross-presentation of EBOV antigens obtained from cell debris of EBOV-infected cells. Of note, rather than interfering with cross-presentation, EBOV infection enhanced the cross-presentation capacity of DCs. Our findings indicate that EBOV infection of Flt3-dependent cDCs, results in activation rather than inhibition leading to high levels of CD8 T-cell activation. With that we propose a mechanistic explanation for the excess T-cell activation observed in severe human EVD.

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Classical DC2 subsets and monocyte‐derived DC: Delineating the developmental and functional relationship

Cited by 11 publications

References 150 publications

Dendritic cells: the yin and yang in disease progression

Dendritic cells: the yin and yang in disease progression

Insights into dendritic cell maturation during infection with application of advanced imaging techniques

Ebola virus infection of Flt3-dependent, conventional dendritic cells and antigen cross-presentation leads to high levels of T-cell activation

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