Classical conditioning of the rabbit eyelid response with mossy fiber stimulation as the conditioned stimulus

Steinmetz, Joseph E.; Lavond, David G.; Thompson, Richard F.

doi:10.3758/bf03329839

Cited by 62 publications

(33 citation statements)

References 39 publications

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“…Extensive mapping of recording information taken from rabbits trained using a tone-conditioned stimulus has verified that models of learning-related unit activity as well as toneevoked unit activity occur extensively throughout the pontine midbrain (McCormick et al 1983). Steinmetz et al (1985 and have shown that direct stimulation of either the middle cerebellar peduncle or the dorsolateral, lateral, and medial pontine nuclei may serve as the conditioned stimulus in this paradigm. Lesions of the dorsolateral pons, the caudal lateral pons, and the lateral lemniscus abolish conditioned responses to a toneconditioned stimulus (Steinmetz et al 1987).…”

Section: And 527mentioning

confidence: 99%

The effects of reversible inactivation of the red nucleus on learning-related and auditory-evoked unit activity in the pontine nuclei of classically conditioned rabbits.

Cartford

Gohl²,

Singson³

et al. 1997

Learn. Mem.

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The pontine nuclei carry auditory conditioned stimulus information to the cerebellum during classical conditioning of the nictitating membrane response in rabbits. In well-trained animals learning-related as well as stimulus-evoked unit activity can be recorded throughout the pontine nuclei but particularly in the lateral and dorsolateral pons. Recent work in our laboratory has provided evidence that the learning-related unit activity in the pons is dependent on the interpositus nucleus and that the pons is not a site of essential plasticity for the learned response. In the present study we considered the question of whether learning-related unit activity might be projected from the interpositus nucleus to the pons through the red nucleus, a primary output target of the interpositus and a structure known to be essential for expression of the learned response. Multiple unit recordings were taken from lateral and dorsolateral pontine locations in well-trained rabbits before and during cooling of the red nucleus. Analysis of pooled data for all recording locations within the lateral and dorsolateral pons indicated that reversible inactivation of red nucleus abolished both stimulus-evoked and learning-related unit activity. However, we also found discrete recording locations where stimulus-evoked and learning-related 1Corresponding author. unit activity were attenuated but not abolished by red nucleus cooling.

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Section: And 527mentioning

confidence: 99%

The effects of reversible inactivation of the red nucleus on learning-related and auditory-evoked unit activity in the pontine nuclei of classically conditioned rabbits.

Cartford

Gohl²,

Singson³

et al. 1997

Learn. Mem.

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show abstract

“…Stimulation of the pontine nuclei or of the middle cerebellar peduncle can be used as an effective conditioning stimulus (Steinmetz et al 1985. In fact, pontine stimulation as a CS yields more rapid acquisition than exteroceptive CSs.…”

Section: Introductionmentioning

confidence: 99%

The learning-related activity that develops in the pontine nuclei during classical eye-blink conditioning is dependent on the interpositus nucleus.

Clark¹,

Gohl²,

Lavond³

1997

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A growing body of research now implicates the cerebellum in the formation and storage of the critical neural plasticity that subserves the classically conditioned eye-blink response. Previous anatomical, physiological, and behavioral research suggests that auditory-conditioned stimulus information is routed to the cerebellum by the pontine nuclei. However, it has also been observed from multiple unit recordings that some populations of pontine cells, in addition to showing auditory-evoked responses, also show changes in activity that is learning-related. It is unknown whether this learning-related activity is generated by the pontine cells or whether it is generated by some other structure and projected to the pontine nuclei. Because the cerebellum has been implicated in the formation of the essential plasticity that subserves this learned behavior, we examined how multiple unit recordings of learning-related activity within the pontine nuclei are affected by reversible inactivation of the interpositus nucleus of the cerebellum. The results indicated clearly that when the interpositus nucleus was inactivated, the learning-related activity in the pontine nuclei was abolished completely and the auditory stimulus-evoked activity was unaffected. In contract, when the facial nucleus was inactivated, both the auditory stimulus and the learning-related activity 1Corresponding author.were still present. These results indicate that the learning-related activity exhibited by some populations of pontine nuclei cells is dependent on the interpositus nucleus and may represent feedback from the cerebellum.

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“…The necessary and sufficient circuitry for excitatory eyeblink conditioning exists within the brainstem and cerebellum. The CS pathway includes mossy fiber projections from the pontine nuclei to the cerebellum (Gould, Sears, & Steinmetz, 1993;Lewis, LoTurco, & Solomon, 1987;Solomon, Lewis, LoTurco, Steinmetz, & Thompson, 1986;Steinmetz, Lavond, & Thompson, 1985;Steinmetz, Rosen, Chapman, Lavond, & Thompson, 1986;Steinmetz, Logan, Rosen, Thompson, Lavond, & Thompson, 1987;Steinmetz, Lavond & Thompson, 1989;Steinmetz, 1990;Tracy, Thompson, Krupa, & Thompson, 1998). The US pathway includes climbing fiber projections from the inferior olive to the cerebellum (De Zeeuw, Van Alphen, Hawkins, & Ruigrok, 1997;Gould et al, 1993;Mauk, Steinmetz & Thompson, 1986;McCormick, Steinmetz, & Thompson, 1985;Steinmetz et al, 1989;Yeo, Hardiman, & Glickstein, 1986).…”

Section: Introductionmentioning

confidence: 99%

Blockade of GABAA receptors in the interpositus nucleus modulates expression of conditioned excitation but not conditioned inhibition of the eyeblink response

Nolan

Nicholson

Freeman

2002

Integrative Physiological & Behavioral Science

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The cerebellum and related brainstem structures are essential for excitatory eyeblink conditioning. Recent evidence indicates that the cerebellar interpositus and lateral pontine nuclei may also play critical roles in conditioned inhibition (CI) of the eyeblink response. The current study examined the role of GABAergic inhibition of the interpositus nucleus in retention of CI. Male Long-Evans rats were implanted with a cannula positioned just above or in the anterior interpositus nucleus before training. The rats were trained with two different tones and a light as conditioned stimuli, and a periorbital shock as the unconditioned stimulus. CI training consisted of four phases: 1) excitatory conditioning (8 kHz tone paired with shock); 2) feature-negative discrimination (2 kHz tone paired with shock or 2 kHz tone concurrent with light); 3) summation test (8 kHz tone or 8 kHz tone concurrent with light); and 4) retardation test (light paired with shock). After reaching a criterion level of performance on the feature-negative discrimination (40% discrimination), 0.5 μl picrotoxin (a GABA A receptor antagonist) was infused at one of four concentrations, each concentration infused during separate test sessions. Picrotoxin transiently impaired conditioned responses during trials with the excitatory stimulus (tone) in a dose-dependent manner, but did not significantly impact responding to the inhibitory compound stimulus (tone-light). The results suggest that expression of conditioned inhibition of the eyeblink conditioned response does not require GABAergic inhibition of neurons in the anterior interpositus nucleus.

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Classical conditioning of the rabbit eyelid response with mossy fiber stimulation as the conditioned stimulus

Cited by 62 publications

References 39 publications

The effects of reversible inactivation of the red nucleus on learning-related and auditory-evoked unit activity in the pontine nuclei of classically conditioned rabbits.

The effects of reversible inactivation of the red nucleus on learning-related and auditory-evoked unit activity in the pontine nuclei of classically conditioned rabbits.

The learning-related activity that develops in the pontine nuclei during classical eye-blink conditioning is dependent on the interpositus nucleus.

Blockade of GABAA receptors in the interpositus nucleus modulates expression of conditioned excitation but not conditioned inhibition of the eyeblink response

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