Abstract:Many bacterial, archaeal, and eukaryotic cells divide by binary fission and do so with precision. Yet until fairly recently it was not clear how even a simple cell such as Escherichia coli knows where its middle is so it can divide by septation into two equal daughters. There were many theories, including those that implicated solely physical properties instead of genetic components as the main driver of midpoint recognition. But as with many insights into how cells work, mutants with abnormal phenotypes were … Show more
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