Classic Gout in Hageman Factor (Factor XII) Deficiency

Contact Factors in Health and Disease

“…100 However, no significant clinical abnormality of inflammation has yet been detected in Factor XII deficiency. It should be pointed out that rheumatoid arthritis, 27 systemic lupus erythematosus, 84 and gout 40 have been described in severe Factor XII deficiency. Similarly, a recent article reported on a 56-year-old man with less than 1% Factor XII activity who had an acute myocardial infarction, gout, and angioimmunoblastic lymphadenopathy.…”

“…In contrast, chickens lacking the contact factors were reported to develop gout spontaneously, 20 and the coexis tence of Factor XII deficiency and gout or rheuma toid arthritis was documented. 27,40 Thus, although a role for the contact factors in arthritis cannot be excluded, it appears that they are not essential in the pathogenesis.…”

Crystal-induced joint inflammation

“…Tuttavia, come già osservato per il Complemento, il sistema della coagulazione non è necessario per lo sviluppo dell'infiammazione da UMS. Infatti, la gotta è stata segnalata in pazienti con deficit di fattore di Hageman (27,28) e una risposta infiammatoria acuta all'iniezione di cristalli di UMS si è osservata in pulcini deprivati di fattore di Hageman (29).…”