Journal of Cell Biology volume 217, issue 4, P1249-1268 2018 DOI: 10.1083/jcb.201611150 View full text
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Clara Gomis-Coloma, Sergio Velasco-Aviles, Jose A. Gomez-Sanchez, Angeles Casillas-Bajo, Johannes Backs, Hugo Cabedo

Abstract: cAMP signaling regulates Schwann myelination by a mechanism that is not clearly understood. The authors provide in vitro and in vivo data showing that cAMP shuttles HDAC4 into the nucleus, where it forms a complex with NcoR1/HDAC3 to repress the expression of c-Jun, inducing Schwann cell differentiation and myelin development.