Class IIa histone deacetylases: conducting development and differentiation

Martin, Maud; Kettmann, Richard; Dequiedt, Samuel

doi:10.1387/ijdb.082698mm

Cited by 60 publications

(56 citation statements)

References 142 publications

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“…Muscle Development-Myogenesis encompasses the conversion of myoblasts into differentiated myotubes and involves the activation of hundreds of muscle-specific genes and concomitant repression of cell proliferation genes (14). In undifferentiated cells, MEF2 transcription factors are repressed when in a complex with HDAC4 or HDAC5 (133), which undergo nuclear export upon phosphorylation of 14 -3-3 binding sites by GIT1 and CaMKs (27,36).…”

Section: Hdac5-although Numerous Hdac5mentioning

confidence: 99%

“…In recent years, the class IIa HDACs have been established as critical regulators of numerous cellular processes (14,15), with misregulation being associated with a wide range of human diseases. Roles for class IIa HDACs have been reported in the development of cardiovascular disease (16), cancer (17), immune response to viral infection (18), epigenetic response to drug stimulus (19), diabetes (20), and neurodegenerative diseases, such as Huntington's disease (21).…”

mentioning

confidence: 99%

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Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

Mathias

Guise

Cristea

2015

Molecular & Cellular Proteomics

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Class IIa histone deacetylases (HDACs4, -5, -7, and -9) modulate the physiology of the human cardiovascular, musculoskeletal, nervous, and immune systems. The regulatory capacity of this family of enzymes stems from their ability to shuttle between nuclear and cytoplasmic compartments in response to signal-driven post-translational modification. Here, we review the current knowledge of modifications that control spatial and temporal histone deacetylase functions by regulating subcellular localization, transcriptional functions, and cell cycle-dependent activity, ultimately impacting on human disease. We discuss the contribution of these modifications to cardiac and vascular hypertrophy, myoblast differentiation, neuronal cell survival, and neurodegenerative disorders. Molecular & Cellular

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Section: Hdac5-although Numerous Hdac5mentioning

confidence: 99%

mentioning

confidence: 99%

Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

Mathias

Guise

Cristea

2015

Molecular & Cellular Proteomics

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“…HDACs shuttle between the cytoplasm and nucleus in response to extracellular signals, a process linked to both post translational modification and protein-protein interactions. 23 Serine phosphorylated HDAC is released from DNA-binding partners to link with 14-3-3 subunits for nuclear export. 24 This complex is generally thought to be in an inhibitory state; unable to interact with other transcription factors (as a repressor) and sequestered from histones.…”

mentioning

confidence: 99%

“…Classically, this allows chromatin expansion and permissive transcriptional activity. 23 In particular, HDAC7 has a unique role in endothelial regulation. 23 Some of its functions parallel ␤-catenin, including vascular integrity and intercellular adherence.…”

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confidence: 99%

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Temporal and Spatial Regulation of Histone Deacetylase-7 and β-Catenin in Endothelial Cells

Hui

Brunt

Husain

2010

Circulation Research

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Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

Thaler

Mercurio

2013

ChemMedChem

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Histone deacetylases (HDACs) are widely studied targets for the treatment of cancer and other diseases. Up to now, over twenty HDAC inhibitors have entered clinical studies and two of them have already reached the market, namely the hydroxamic acid derivative SAHA (vorinostat, Zolinza) and the cyclic depsipeptide FK228 (romidepsin, Istodax) that have been approved for the treatment of cutaneous T-cell lymphoma (CTCL). A common aspect of the first HDAC inhibitors is the absence of any particular selectivity towards specific isozymes. Some of molecules resulted to be “pan”-HDAC inhibitors, while others are class I selective. In the meantime, the knowledge of HDAC biology has continuously progressed. Key advances in the structural biology of various isozymes, reliable molecular homology models as well as suitable biological assays have provided new tools for drug discovery activities. This Minireview aims at surveying these recent developments as well as the design, synthesis and biological characterization of isoform-selective derivatives.

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Class IIa histone deacetylases: conducting development and differentiation

Cited by 60 publications

References 142 publications

Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

Post-translational Modifications Regulate Class IIa Histone Deacetylase (HDAC) Function in Health and Disease

Temporal and Spatial Regulation of Histone Deacetylase-7 and β-Catenin in Endothelial Cells

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

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