Class II HLA allele polymorphism: DRB1, DQB1 and DPB1 alleles and haplotypes in the New Zealand Maori population

Tracey, M. C.; Carter, J. M.

doi:10.1111/j.1399-0039.2006.00671.x

Cited by 10 publications

(19 citation statements)

References 19 publications

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“…Therefore, we ran exact tests using MFA, MAH and TTM datasets and all comparisons turned to be significantly different from one another (see Table S3). In contrast to Polynesians, where VTP is equivalent to PFA in terms of un‐admixed Polynesian gene content, here we have shown TTM most closely resembles MAH and suggests greater degree of admixture in datasets than . To best illustrate these comparisons, we have plotted HLA classes I and II allele frequency spectra for the various Maori (Figures and ) and Polynesian (not shown) datasets against the two reference European populations, ELAN (class I‐ref 7) and ENG (class II‐ref 8).…”

Section: Resultsmentioning

confidence: 80%

“… N , total number of individuals; k, total number of observed alleles; 0, not observed; 0.00, <0.01; TP, Total Polynesians; PFA, Polynesians with Full Ancestry; PAH, Polynesians with Admixed History; TM, Total Maori; MFA, Maori with Full Ancestry; MAH, Maori with Admixed History; CI, Cook Islands ; TOK, Tokelau ; TON, Tonga ; SA, Samoa ; VTP, Velickovic Total Polynesians (CI + TOK + TON + SA); PMD, Polynesian Meta Dataset (PFA + VTP); TTM, Tracey Total Maori ; MMD, Maori Meta Dataset (TM + TTM).…”

Section: Resultsmentioning

confidence: 99%

“…Genetic relationships between Polynesians and other Asia Pacific populations were probed using HLA‐DRB1 and ‐ DQB1 allele frequencies PCO plots (axes 1 and 2). TM , Total Maori; MFA , Maori with Full Ancestry; MAH , Maori with Admixed History; TP , Total Polynesians; PFA , Polynesians with Full Ancestry; PAH , Polynesians with Admixed History; VTP , Velickovic Total Polynesians (Cook Islands + Tokelau + Tonga + Samoa); PMD , Polynesians Meta Dataset ( VTP + PFA ); TTM , Tracey Total Maori; PNG , Papua New Guinea; ENG , England.…”

Section: Resultsmentioning

confidence: 99%

“…Studies on immune system loci have played a leading part in the development of genetic evidence that underpins the received account . Our present study examines Human Leukocyte Antigens (HLA) markers in DNA samples that have been classified according to reported admixture.…”

Section: Introductionmentioning

confidence: 99%

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Using HLA loci to inform ancestry and health in Polynesian and Maori populations

Edinur

Dunn²,

Hammond³

et al. 2012

Tissue Antigens

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Human leukocyte antigens (HLA) are important genetic markers of tissue identity and accurately reflect ancestral history. The work reported in this paper provides a detailed description of HLA polymorphism in Polynesian and Maori individuals in relation to other populations. Our study concerns HLA classes I and II antigens in Polynesian (N = 36) and Maori (N = 114) subjects genotyped at two digit resolution by New Zealand Blood Service Laboratory in Auckland using polymerase chain reaction-sequence specific oligonucleotide and PCR-SSP technologies. We have also compared our data with those from other Austronesian-speaking Mongoloid and Papuan-speaking Australoid populations in order to test previously published account of the origin of Proto-Polynesians via gender-biassed gene flow between these two ancestral populations. We use principal coordinate analysis for this purpose, arguing this approach to be superior to tree-based methods, because of factors associated with population history and admixture. Our data are in general agreement with earlier work and reflect received wisdom on the dual origin of Proto-Polynesians. They also show the way in which the genetic make-up of Polynesian and Maori subjects is changing due to intermarriage with Europeans.

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Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Using HLA loci to inform ancestry and health in Polynesian and Maori populations

Edinur

Dunn²,

Hammond³

et al. 2012

Tissue Antigens

View full text Add to dashboard Cite

show abstract

“…The HLA allele frequencies of Māori and Polynesian populations reflect this ancestry, with common alleles and haplotypes being also common in the populations of Taiwan, Island Southeast Asia or Near Oceania (Gonzalez-Galarza et al 2011; Kostyu et al 1984; Tracey and Carter 2006). Rare alleles and haplotypes tend to stem from modern or historical admixture, such as those shared by Europeans and New Zealand Māori or by Amerindians and Easter Islanders (Edinur et al 2012; Roberts et al 2013; Thorsby 2012).…”

Section: Introductionmentioning

confidence: 99%

KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand

et al. 2014

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HLA class I molecules and killer cell immunoglobulin-like receptors (KIR) form a diverse system of ligands and receptors that individualize human immune systems in ways that improve the survival of individuals and populations. Human settlement of Oceania by island-hopping East and Southeast Asian migrants started ~3,500 years ago. Subsequently, New Zealand was reached ~750 years ago by ancestral Māori. To examine how this history impacted KIR and HLA diversity, and their functional interaction, we defined at high resolution the allelic and haplotype diversity of the 13 expressed KIR genes in 49 Māori and 34 Polynesians. Eighty KIR variants, including four ‘new’ alleles, were defined; as were 35 centromeric and 22 telomeric KIR region haplotypes, which combine to give >50 full-length KIR haplotypes. Two new and divergent variant KIR form part of a telomeric KIR haplotype, which appears derived from Papua New Guinea and was probably obtained by the Asian migrants en route to Polynesia. Māori and Polynesian KIR are very similar, but differ significantly from African, European, Japanese and Amerindian KIR. Māori and Polynesians have high KIR haplotype diversity with corresponding allotype diversity being maintained throughout the KIR locus. Within the population each individual has a unique combination of HLA class I and KIR. Characterizing Māori and Polynesians is a paucity of HLA-B allotypes recognized by KIR. Compensating for this deficiency are high frequencies (>50%) of HLA-A allotypes recognized by KIR. These HLA-A allotypes are ones that modern humans likely acquired from archaic humans at a much earlier time.

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Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders

et al. 2020

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Objectives A dysregulated inflammatory response against the dopamine‐2 receptor (D2R) has been implicated in movement and psychiatric disorders. D2R antibodies were previously reported in a subset of these patients; however, the role of T cells in these disorders remains unknown. Our objective was to identify and characterise pro‐inflammatory D2R‐specific T cells in movement and psychiatric disorders. Methods Blood from paediatric patients with movement and psychiatric disorders of suspected autoimmune and neurodevelopmental aetiology (n = 24) and controls (n = 16) was cultured in vitro with a human D2R peptide library, and D2R‐specific T cells were identified by flow cytometric quantification of CD4+CD25+CD134+ T cells. Cytokine secretion was analysed using a cytometric bead array and ELISA. HLA genotypes were examined in D2R‐specific T‐cell‐positive patients. D2R antibody seropositivity was determined using a flow cytometry live cell‐based assay. Results Three immunodominant regions of D2R, amino acid (aa)121–131, aa171–181 and aa396–416, specifically activated CD4+ T cells in 8/24 patients. Peptides corresponding to these regions were predicted to bind with high affinity to the HLA of the eight positive patients and had also elicited the secretion of pro‐inflammatory cytokines IL‐2, IFN‐ γ, TNF, IL‐6, IL‐17A and IL‐17F. All eight patients were seronegative for D2R antibodies. Conclusion Autoreactive D2R‐specific T cells and a pro‐inflammatory Th1 and Th17 cytokine profile characterise a subset of paediatric patients with movement and psychiatric disorders, further underpinning the theory of immune dysregulation in these disorders. These findings offer new perspectives into the neuroinflammatory mechanisms of movement and psychiatric disorders and can influence patient diagnosis and treatment.

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Class II HLA allele polymorphism: DRB1, DQB1 and DPB1 alleles and haplotypes in the New Zealand Maori population

Cited by 10 publications

References 19 publications

Using HLA loci to inform ancestry and health in Polynesian and Maori populations

Using HLA loci to inform ancestry and health in Polynesian and Maori populations

KIR diversity in Māori and Polynesians: populations in which HLA-B is not a significant KIR ligand

Pro‐inflammatory dopamine‐2 receptor‐specific T cells in paediatric movement and psychiatric disorders

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