Class I histone deacetylases inhibition reverses memory impairment induced by acute stress in mice
Heidy Martínez-Pacheco,
Rossana Citlali Zepeda,
Ofir Picazo
et al.
Abstract:While chronic stress induces learning and memory impairments, acute stress may facilitate or prevent memory consolidation depending on whether it occurs during the learning event or before it, respectively. On the other hand, it has been shown that histone acetylation regulates long-term memory formation. This study aimed to evaluate the effect of two inhibitors of class I histone deacetylases (HDACs), 4-phenylbutyrate (PB) and IN14 (100 mg/kg/day, ip for 2 days), on memory performance in mice exposed to a sin… Show more
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