Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis

Brunner, HI; Ivăsková, E; Haas, Johannes-Peter; Andreas, A.; Keller, E.; Hoza, J; Havelka, S; Scholz, Siegfried; Sierp, G.; Albert, E. D.

doi:10.1007/bf00307739

Cited by 31 publications

(26 citation statements)

References 14 publications

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“…In particular, HLA-A2 allele is associated with different JIA subtypes, especially those with earlier onset [15][16][17]. Enthesitis-related JIA is associated with HLA-B27, whereas oligoarticular JIA has been shown to be associated with HLA-A2, DR5, and DR8 [15][16][17]. The infrequent observation of HLA DRB1*04 and DRB1*07 in children with oligoarthritides should suggest the protective role exhibited by these haplotypes.…”

Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 91%

“…The infrequent observation of HLA DRB1*04 and DRB1*07 in children with oligoarthritides should suggest the protective role exhibited by these haplotypes. Rheumatoid factor-negative polyarticular JIA is mainly associated with DRB1*08 and DPB1*03, whereas the rheumatoid factorpositive polyarticular variant is associated with DRB1*04, DQA1*03, and DQB1*03 haplotypes [15][16][17]. In the end, HLA DRB1*01 and DQA1*010 have been associated with the psoriatic variant of JIA [15][16][17].…”

Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 95%

“…The consistency of HLA associations in different populations reported by independent investigators has provided convincing evidence of the validity of such observations. In particular, HLA-A2 allele is associated with different JIA subtypes, especially those with earlier onset [15][16][17]. Enthesitis-related JIA is associated with HLA-B27, whereas oligoarticular JIA has been shown to be associated with HLA-A2, DR5, and DR8 [15][16][17].…”

Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 97%

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The Etiology of Juvenile Idiopathic Arthritis

Rigante

Bosco

Esposito

2014

Clinic Rev Allerg Immunol

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Over the years, the commonly used term to describe juvenile idiopathic arthritis (JIA) has changed. By definition, JIA includes all types of arthritis with no apparent cause, lasting more than 6 weeks, in patients aged less than 16 years at onset. JIA pathogenesis is still poorly understood: the interaction between environmental factors and multiple genes has been proposed as the most relevant working mechanism to the development of JIA. The concept that various microbes that colonize or infect not only the mucosal surfaces, like the oral cavity, but also the airways and gut might trigger autoimmune processes, resulting in chronic arthritides, and JIA was first drafted at the outset of last century. JIA development might be initiated and sustained by the exposure to environmental factors, including infectious agents which affect people at a young age, depending on the underlying genetic predisposition to synovial inflammation. Many data from patients with JIA suggest a scenario in which different external antigens incite multiple antigen-specific pathways, cytotoxic T cell responses, activation of classical complement cascade, and production of proinflammatory cytokines. In this review, emphasis is paid not only to the potential role of parvovirus B19 and Epstein-Barr virus in primis but also to the general involvement of different bacteria as Salmonella spp., Shigella spp., Campylobacter spp., Mycoplasma pneumoniae, Chlamydophila pneumoniae, Bartonella henselae, and Streptococcus pyogenes for the development of immune-mediated arthritides during childhood. No unequivocal evidence favoring or refuting these associations has been clearly proved, and today, the strict definition of JIA etiology remains unknown. The infection can represent a random event in a susceptible individual, or it can be a necessary factor in JIA development, always in combination with a peculiar genetic background. Further studies are needed in order to address the unsolved questions concerning this issue.

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Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 91%

Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 95%

Section: Genetic Predisposing Factors To Juvenile Idiopathic Arthritismentioning

confidence: 97%

See 1 more Smart Citation

The Etiology of Juvenile Idiopathic Arthritis

Rigante

Bosco

Esposito

2014

Clinic Rev Allerg Immunol

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“…Several studies have reported association of JRA with different human HLA class II alleles by either serological or DNA typing techniques, but the majority of these findings come from studies performed in whites [13][14][15][16]. For the polyarticular JRA, the alleles HLA-DB1*0401, DRB1*01, and DRB1*08 have been found to be associated with susceptibility [17][18][19][20][21][22][23][24][25][26]. For the pauciarticular or oligoarticular onset, which is the most common and most extensively studied subgroup, the alleles HLA-DRB1*08, DRB1*11, DRB1*13, and DQB1*0402 [18 -19] are associated with susceptibility.…”

Section: Introductionmentioning

confidence: 99%

HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos

et al. 2004

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“…Above-normal frequencies have been found in JCA patients with both the polyarticular and the pauciarticular-onset subtypes [1,3,[5][6][7][8]10], although in some series this phenomenon seemed to be restricted to late-onset pauciarticular disease [4,12]. Only a few studies have shown elevated frequencies in seropositive adult-type JCA [11] or in Still's disease [8,10], whereas several others have revealed normal [3,4,10,[12][13][14] or only marginally elevated frequencies in these subtypes of JCA or in JCA patients in general [2,[15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

HLA B27: A prognostic factor in juvenile chronic arthritis

Savolainen¹,

Lehtimäki

Kautiainen³

et al. 1998

Clin Rheumatol

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This study was performed to assess the frequency of HLA B27 in patients with juvenile chronic arthritis (JCA) of varying severity and outcome by studying three patient categories: those in whom cytostatic treatment with azathioprine had been started, those with secondary amyloidosis, and those with arthroplasty of the knee or hip joints. In the first category the frequency of the HLA B27 allele was compared between those who had attained remission and those who had not. In the second and third categories the rate at which amyloidosis developed and the timing for the need of arthroplasty, were compared for HLA B27-positive and -negative patients. A control group consisted of 37 patients with uncomplicated seronegative polyarthritis. Ten of the 37 patients in the control group (27%) were HLA B27 positive as opposed to 84 out of 190 (44%) in the three study groups. Of the 101 patients treated with azathioprine, two out of 15 in remission were HLA B27 positive, whereas as many as 41 out of 86 with still active disease were HLA B27 positive (p = 0.013). Of the secondary amyloidosis patients, 29 out of 51 carried HLA B27. The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients (p = 0.038). Of the arthroplasty patients, 39 out of 91 carried HLA B27. The HLA B27-positive patients underwent arthroplasty on average 2.9 (median 3.5) years earlier than the HLA B27-negative patients (p = 0.050). We conclude that HLA B27-positive cases are accumulated among the most severe cases of JCA.

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Class I associations and frequencies of class II HLA-DRB alleles by RFLP analysis in children with rheumatoid-factor-negative juvenile chronic arthritis

Cited by 31 publications

References 14 publications

The Etiology of Juvenile Idiopathic Arthritis

The Etiology of Juvenile Idiopathic Arthritis

HLA-DRB1 alleles and HLA-DRB1 shared epitopes are markers for juvenile rheumatoid arthritis subgroups in Colombian mestizos

HLA B27: A prognostic factor in juvenile chronic arthritis

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