Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma

Amayasu, Hideaki; Yoshida, Satoshi; Ebana, Shoichi; Yamamoto, Yoshiharu; Nishikawa, Tetsuo; Shoji, Tatsuhiro; Nakagawa, Hiroshi; Hasegawa, Hiroshi; Nakabayashi, Masaru; Ishizaki, Yuko

doi:10.1016/s1081-1206(10)62409-x

Cited by 138 publications

(113 citation statements)

References 15 publications

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“…Two studies have shown significant reductions in bronchial hyperresponsiveness in patients with asthma after 8 weeks' treatment with clarithromycin; neither showed any significant change in FEV1 [47,50]. The first study examined 17 patients with allergy-induced asthma and demonstrated a significant reduction in blood and sputum eosinophil counts, suggesting a possible anti-inflammatory role for clarithromycin [50].…”

Section: Asthmamentioning

confidence: 99%

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Long-term macrolide therapy in chronic inflammatory airway diseases

Crosbie¹,

Woodhead²

2009

European Respiratory Journal

119

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In addition to direct antibacterial actions, 14-and 15-member-ring macrolides have immune modulating effects that appear to be the reason for clinical benefit in diffuse panbronchiolitis.A literature search was conducted for studies of the clinical effectiveness of macrolides in other chronic lung conditions.A number of studies were identified that showed short-term beneficial outcomes or the potential for such outcomes in cystic fibrosis, bronchiectasis, chronic obstructive pulmonary disease, asthma and post-transplant obliterative bronchiolitis. The studies were limited by small patient numbers, different outcome measures and short-term follow-up, and were not designed to assess potentially harmful effects.Further large prospective and long-term studies are required in order to identify potential benefit and harm before these agents can be recommended routinely for these conditions.

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Section: Asthmamentioning

confidence: 99%

“…The first study examined 17 patients with allergy-induced asthma and demonstrated a significant reduction in blood and sputum eosinophil counts, suggesting a possible anti-inflammatory role for clarithromycin [50]. Patients taking oral or inhaled corticosteroid were excluded.…”

Section: Asthmamentioning

confidence: 99%

Long-term macrolide therapy in chronic inflammatory airway diseases

Crosbie¹,

Woodhead²

2009

European Respiratory Journal

119

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“…Beyond specific antibacterial activity, macrolides have unspecific anti-inflammatory activity, which has been used in diffuse panbronchiolitis, atopic dermatitis, asthma, bronchiectases, cystic fibrosis, bronchiolitis obliterans and inflammatory bowel diseases [16][17][18][19]. The efficacy of these antibiotics in COP has been demonstrated in few studies [20][21] and in previous research by the present authors [22].…”

Section: Discussionmentioning

confidence: 56%

Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia

Radzikowska¹,

Roży²,

Jaguś³

et al. 2016

Adv Clin Exp Med

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“…Such properties other than the antibiotic actions have been well studied and applied to the therapy for chronic neutrophilic inflammatory airway diseases, including diffuse panbronchiolitis (DPB) [11] and sinobronchial syndrome (SBS) [12]. In addition, the effects of macrolides on bronchial asthma have been investigated in recent clinical studies [13][14][15][16]. These studies demonstrated that, in bronchial asthma, although the effects of macrolides on bronchcoconstriction remain controversial, the symptom score, including cough, was observed to improve [13,15] by treatment with these agents.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the effects of macrolides on bronchial asthma have been investigated in recent clinical studies [13][14][15][16]. These studies demonstrated that, in bronchial asthma, although the effects of macrolides on bronchcoconstriction remain controversial, the symptom score, including cough, was observed to improve [13,15] by treatment with these agents. However, there have so far not been any reports concerning the effects of macrolides on the cough reflex hypersensitivity associated with the eosinophilic inflammatory airway diseases, such as NAEB and AC.…”

Section: Introductionmentioning

confidence: 99%

Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs

Tokuda¹,

Ohkura²,

Fujimura³

et al. 2010

Pulmonary Pharmacology & Therapeutics

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Hence, they are used for both acute and chronic inflammatory airway diseases.However, the effects of these agents on allergic airway disorders presenting with an isolated chronic cough, such as non-asthmatic eosinophilic bronchitis and eosinophilic tracheobronchitis with cough hypersensitivity (atopic cough), still remain to be elucidated.Objective: To determine if macrolides are effective in the management of chronic cough caused by eosinophilic airway inflammation. Methods:The cough reflex sensitivity to inhaled capsaicin was measured at 48 h after challenge with an aerosolized antigen in actively sensitized guinea pigs.The 14-, 15-or 16-membered macrolides (erythromycin, azythromycin, or josamycin, respectively) were given intraperitoneally every 12 h after the antigen challenge. Bronchoalveolar lavage and the resection of the tracheal tissue were performed immediately after the measurement of the cough response to capsaicin. Results:The antigen-induced increase in the number of coughs elicited by capsaicin inhalation was significantly reduced by treatments with erythromycin and azythromycin, but not with josamycin. Erythromycin dose-dependently inhibited the increases in the substance P, prostaglandin E 2 and leukotriene B 4 levels, but not the histamine levels, in the bronchoalveolar lavage fluid. However, erythromycin did not influence the antigen-induced decrease in the neutral endopeptidase (NEP) activity in the tracheal tissue.Conclusions: Both 14-and 15-membered, but not 16-membered, macrolides 3 could reduce the antigen-induced cough reflex hypersensitivity by inhibiting the antigen-induced release of the afferent sensory nerve sensitizers. These macrolides may be therapeutically useful for the treatment of isolated chronic cough based on cough reflex hypersensitivity in allergic airway diseases such as non-asthmatic eosinophilic bronchitis and atopic cough.

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Clarithromycin suppresses bronchial hyperresponsiveness associated with eosinophilic inflammation in patients with asthma

Cited by 138 publications

References 15 publications

Long-term macrolide therapy in chronic inflammatory airway diseases

Long-term macrolide therapy in chronic inflammatory airway diseases

Clarithromycin Decreases IL-6 Concentration in Serum and BAL Fluid in Patients with Cryptogenic Organizing Pneumonia

Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs

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