Clarithromycin Resistance of <i>Helicobacter pylori</i> Strains Isolated from Children’ Gastric Antrum and Fundus as Assessed by Fluorescent In‐situ Hybridization and Culture on Four‐Sector Agar Plates

Caristo, E.; Parola, Andrea; Rapa, Anna; Vivenza, Daniela; Raselli, Barbara; Dondi, Elena; Boldorini, Renzo; Oderda, Giuseppina

doi:10.1111/j.1523-5378.2008.00642.x

Cited by 23 publications

(19 citation statements)

References 34 publications

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“…A direct comparison of our data with those from other studies concentrating on pediatric H. pylori isolates is hampered by the use of distinct breakpoints for some antibiotics tested. Still, considerable rates of resistance to metronidazole or clarithromycin or both have been shown for several European countries including Austria, Belgium, France, Italy, Portugal, Spain, and Eastern Europe, and the same has been concluded from the European multicenter study . Not surprisingly and supported by data from others, we also observed higher resistance rates to these drugs by H. pylori isolates from pretreated children/adolescents (secondary resistance) than by bacterial isolates from treatment‐naïve patients.…”

Section: Discussionsupporting

confidence: 90%

Increasing metronidazole and rifampicin resistance of Helicobacter pylori isolates obtained from children and adolescents between 2002 and 2015 in southwest Germany

Regnath¹,

Raecke

Enninger

et al. 2016

Helicobacter

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Section: Discussionsupporting

confidence: 90%

Increasing metronidazole and rifampicin resistance of Helicobacter pylori isolates obtained from children and adolescents between 2002 and 2015 in southwest Germany

Regnath¹,

Raecke

Enninger

et al. 2016

Helicobacter

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“…Our finding confirms in adults the results observed in a paediatric population. 11 In agreement with previous investigations, 4,6,7 our results found a high prevalence of heteroresistance for clarithromycin in each gastric sites (intraniche heteroresistance). Moreover, the finding of a significant interniche heteroresistance rate (16%) would appears of clinical relevance because of the quite constant involvement of the A2143G mutate genotype.…”

Section: Discussionsupporting

confidence: 93%

Helicobacter pylori clarithromycin resistance assessment: are gastric antral biopsies sufficient?

Francesco

Giorgio

Ierardi

et al. 2012

Gastroenterol Insights

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Gastric biopsy sampling could affect accuracy of Helicobacter pylori clarithromycin resistance assessment due to coexistence of susceptible and resistant strains (i.e. heteroresistance) either in same gastric site (intraniche) or in two different gastric sites (interniche). This study aimed to assess differences in the H. pylori clarithromycin resistance prevalence in relation to the gastric biopsy sampling by using Taqman-real time polymerase chain reaction (PCR). The study enrolled 137 patients. Primary clarithromycin resistance was observed in 15 isolates exclusively in antrum, in 7 cases exclusively in gastric body, and in 3 patients in both gastric sites. The overall prevalence of clarithromycin resistance was 13.1% by using exclusively antral biopsies, and 18.2% by using biopsies from both gastric sites. Moreover, intra-niche heteroresistance was observed in 19 (76%) out of 25 patients harbouring resistant strains. Our data found a heterogeneous distribution of resistant H. pylori strains in the stomach. Similarly to culture, gastric biopsies from both antrum and gastric body are needed to increase the accuracy of PCR-based methods for clarithromycin resistance assessment.

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“…At the same time, the micro-evolution is very common in China, leading to changes of gastric flora. Strains of H. pylori with more than two kinds of genotypes exist in 99% of the hosts, resulting in repeated drug resistance and recurrence (Table 1)[53]. …”

Section: Relationship Between H Pylori Pathogenic Genes and Gastroinmentioning

confidence: 99%

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

Chen¹,

Mo²,

Huang³

et al. 2016

WJG

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Helicobacter pylori (H. pylori) is a kind of chronic infectious pathogen which can cause chronic gastritis, peptic ulcer, gastric cancer and other diseases. The genetic structure of the pathogenic genes of H. pylori varies largely, which contributes to the differences in virulence among various strains, and in clinical symptoms. Virulence genes of H. pylori can be categorized into three main classes: those related to adhesion and colonization, those related to gastric mucosal injury, and others. This review focuses on the relationship between genetic polymorphisms of the three classes of virulence genes of H. pylori and diseases. Most of the genetic polymorphisms of the main virulence factors of H. pylori are summarized in this paper.

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Clarithromycin Resistance of Helicobacter pylori Strains Isolated from Children’ Gastric Antrum and Fundus as Assessed by Fluorescent In‐situ Hybridization and Culture on Four‐Sector Agar Plates

Cited by 23 publications

References 34 publications

Increasing metronidazole and rifampicin resistance of Helicobacter pylori isolates obtained from children and adolescents between 2002 and 2015 in southwest Germany

Increasing metronidazole and rifampicin resistance of Helicobacter pylori isolates obtained from children and adolescents between 2002 and 2015 in southwest Germany

Helicobacter pylori clarithromycin resistance assessment: are gastric antral biopsies sufficient?

Gene polymorphisms of pathogenic Helicobacter pylori in patients with different types of gastrointestinal diseases

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