Clarithromycin for the cure of Helicobacter pylori infection: One or two weeks of treatment

One‐week clarithromycin triple therapy regimens for eradication of Helicobacter pylori

“…O 40 mg/day (usually given as 20 mg b.d. ) 35 , 38 , 39 , 44 , 48 –50 , 56 , 64 , 127 , 128 , 130 –137 , 142 –147 , 149 –151 , 153 resulted in 85.0% ( n = 1469/1729) eradication compared with 78.0% ( n = 534/685) with O 20 mg/day 36 , . 125 , 129 , 131 , 132 , 138 –141 , 144 , 148 , 152…”

“…Of 46 reported studies, 35 , 36 , 38 , 39 , 44 , 48 –50 , 56 , 64 , 125 , 127 –153 ITT rates could be determined from all but eight 69 , . 78 , 154 –159 The pooled eradication rate was 83.0% ( n = 2003/2414); range 45–100% 136 , 139 from 42 treatment arms.…”

“…The dose of C most frequently used was 250 mg b.d 36 , 38 , 44 , 48 –50 , 64 , 125 , 127 –132 , 134 , 135 , 137 –140 , 143 , 144 , 146 , 148 –152 . giving an average eradication rate of 82.9% ( n = 1335/1622); range 45–97% 139 , .…”

“…143 Studies have been reported with M 750 mg b.d., 150 250 mg t.d.s., 148 250 mg q.d.s 144 , . 149 and 250 mg b.d 125 , . 141 Eradication rates ranged from 80 to 86%.…”

Cure of H. pylori Infection Using a 7‐Day Triple Therapy Combining Pantoprazole with Two Antibiotics

“…One week triple therapies comprised of a proton pump inhibitor in combination with clarithromycin and metronidazole or in combination with amoxicillin and clarithromycin have been shown to cure H. pylori very effectively [ 3–6]. In studies with pantoprazole in combination with these antibiotics, similarly high H. pylori eradication rates were obtained as with comparable regimens containing omeprazole [ 9–17].…”