Clarifying the Structure and Bone Mineral Content of Heterotopic Ossification

Isaacson, Brad M.; Brown, Amalia A.; Brunker, Lucille B.; Higgins, Thomas F.; Bloebaum, Roy D.

doi:10.1016/j.jss.2010.12.047

Cited by 35 publications

(32 citation statements)

References 47 publications

(61 reference statements)

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“…[1][2][3][4][5][6][7][8][9] These contexts, normal or otherwise, share fundamental characteristics at many levels, including molecular (overexpression of bone morphogenic proteins, BMPs), cellular (a set of progenitor cells that commits to an osteoblastic lineage) and biomechanical (translation of the mechanical forces into structured and organized bone). [3,[10][11][12][13][14][15] However, there are still significant gaps in our understanding of these events and in particular few models allow long-term Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli. This process can also result in maladaptive ectopic bone in response to injury, yet pathological differences at the molecular and structural levels are poorly understood.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Model for the Development of Mature Bone Containing an Osteocyte Network

et al. 2017

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Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli. This process can also result in maladaptive ectopic bone in response to injury, yet pathological differences at the molecular and structural levels are poorly understood. A number of in vivo models exist but can often be too complex to allow isolation of factors which may stimulate disease progression. A self‐structuring model of bone formation is presented using a fibrin gel cast between two calcium phosphate ceramic anchors. Femoral periosteal cells, seeded into these structures, deposit an ordered matrix that closely resembles mature bone in terms of chemistry (collagen:mineral ratio) and structure, which is adapted over a period of one year in culture. Raman spectroscopy and X‐ray diffraction confirm that the mineral is hydroxyapatite associated with collagen. Second‐harmonic imaging demonstrates that collagen is organized similarly to mature mouse femora. Remarkably, cells differentiated to the osteocyte phase are linked by canaliculi (as demonstrated with nano‐computed tomography) and remained viable over the full year of culture. It is demonstrated that novel drugs can prevent ossification in constructs. This model can be employed to study bone formation in an effort to encourage or prevent ossification in a range of pathologies.

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Section: Introductionmentioning

confidence: 99%

An In Vitro Model for the Development of Mature Bone Containing an Osteocyte Network

et al. 2017

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“…HO is reported to occur in as many as 40% of AS patients, often asymptomatic, and when moderate to severe, results in limited range of motion [Brooker class III-IV] 11, 23 . HO consists of both cancellous and cortical bone with areas of fibrocartilage, and remodeling may continue for as long as 3 years 24 . Contrary to older literature, AS patients appear not to be at greater risk of HO, and have similar rates as patients with diffuse idiopathic skeletal hyperostosis, Paget’s disease, unilateral hypertrophic osteoarthritis, or who have reduced preoperative limitation in hip external rotation 25, 26 .…”

Section: Surgical Considerationsmentioning

confidence: 99%

Physical Therapy and Surgery

Valle-Oñate

Ward

Kerr

et al. 2012

The American Journal of the Medical Sciences

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Physical therapy and orthopedic surgery are important components in the treatment of ankylosing spondylitis (AS). Supervised physical therapy is more effective that individual or unsupervised exercise in improving symptoms, but controlled trials suggest than combined inpatient and outpatient therapy provides the greatest improvement. Recommendations for exercise are universal, but the best types and sequence of therapies are not known. Total hip replacement is the surgery most commonly performed for AS, with good long-term implant survival. Heterotopic ossification may occur no more frequently after hip replacement in patients with AS than in patients with other diseases. Corrective spinal surgery is rarely performed and requires specialized centers and experienced surgeons.

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“…Les para-ostéo-arthropathies neurogènes (POAN) sont des ossifications ectopiques, développées à proximité des grosses articulations, qui correspondent à un processus de néo-ostéogenèse ectopique survenant dans les suites de lésions neurologiques centrales ou périphériques et au décours de certains comas [1][2][3]. Elles sont responsables d'un enraidissement articulaire et d'attitudes vicieuses retentissant lourdement sur la fonction.…”

Section: Introductionunclassified