Clarifying the relationship between sarcopenia and depression in geriatric outpatients

Abstract

Objective: We investigate the relationship between sarcopenia components and depression in geriatric outpatients, considering the effects of potential confounding factors. Methods: Adults !60 years of age were selected from outpatient clinics. Muscle strength was assessed using handgrip strength (HGS) measured using a hydraulic hand dynamometer and chair stand test (CSST). Physical performance was evaluated by usual gait speed (UGS), nutritional status, and frailty were screened by mini-nutritional assessment (MNA) questionnaire and FRAIL scale. Depression was diagnosed through a psychiatric interview and the administration of the Geriatric Depression Scale (GDS). Results: Participants with depression were similar to participants without depression regarding age (p ¼ .055), education (p ¼ .095), frailty (p ¼ .857), and HGS scores (p ¼ .053). The group with depression had longer CSST duration (p ¼ .023), slower UGS (p ¼ .027), and more malnutrition (p ¼ .001). Multivariate regression analysis revealed that only the malnutrition was independently associated factor with depression after adjusting for confounding factors. Conclusions: Depression is associated with malnutrition and some components of sarcopenia in geriatric outpatients. Our results revealed that sarcopenia might be associated with depression through malnutrition. If malnutrition lasts for a long time, sarcopenia may become evident in the later stages of depression.

The longitudinal association between possible new sarcopenia and the depression trajectory of individuals and their intimate partners

“…Depression is a common and important health problem in the elderly population (Delibaş et al, 2021 ). Approximately one in five people is likely to experience depression at some point in their lifetime (Malhi and Mann, 2018 ).…”

Prevalence of sarcopenia and depressive symptoms among older adults: a scoping review

“…Ultimately, 19 studies were included in the final review. [43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61] Twelve studies [43][44][45][52][53][54][55][56][57][59][60][61] were conducted in Asian countries such as China, 44,45,53,54,56 Thailand, 61 Japan 52,57,60 and Korea 59 and only four studies were conducted in non-Asian countries such as Brazil 46,48 and Colombia, 49,50 while three studies were conducted in a transcontinental country, Turkey. 47,51,58 All the research included were cross-sectional studies.…”

Depression and sarcopenia: a Mendelian randomization analysis

“…Furthermore, a decreased physical activity level is an important factor for a decrease in muscle mass and strength (Adachi et al ., 2020). Meanwhile, a recent cross-sectional study suggested that the relationship between sarcopenia and depression may be indirectly related to malnutrition (Delibaş et al ., 2021). Furthermore, the partial androgen deficit of aging males study identified older men who had a partial, progressive, and varied reduction in testosterone and experienced depression, a lack of desire and energy, and a decrease in psychological liveliness (Zarrouf et al ., 2009).…”