Abstract:Eukaryotic translation initiation is a critical node at which gene expression is regulated. Among the factors that are known to regulate this process, DEAD‐box RNA helicases are believed to promote translation by resolving secondary structure in the 5′ UTR of an mRNA. These helicases include the protein Ded1 in budding yeast, which is required to remove cap‐distal structure in the 5′ UTR of an mRNA, thus enabling scanning of the preinitiation complex. Yet the role of Ded1 in translation is complex; a translati… Show more
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