“…Similar conclusions have been drawn from double-inhibitor titration studies (Baum et al, 1971;Hitchens and Kell, 1982a;Westerhoff et al, 1982). Several reports contradict this (Padan and Rottenberg, 1973;Azzone et al, 1978c;Zoratti et al, 1981;Johnson and Hansford, 1977;Branca et al, 1981;Wilson and Forman, 1982;Sorgato et al, 1978;Holian and Wilson, 1980;see, however, Küster et al, 1981;Nicholls and Bernson, 1977;Nicholls, 1979), suggesting that ATP synthesis drains energy from the redox H + pump through a pathway which is not equivalent to Δ/Ι Η utilization for cation transport. The model proposes a stepwise activation of the ATPase depending on the number of H + ions interacting with the enzyme.…”