Clamping, Bending, and Twisting Inter-Domain Motions in the Misfold-Recognising Portion of UDP-Glucose: Glycoprotein Glucosyl-Transferase

Abstract

Highlights d UGGT MD simulations widen the conformational range observed in crystal structures d The UGGT TRXL2 domain is essential for enzymatic activity d A misfold site is closer than the Parodi limit to a glycan in UGGT clients in vitro d N-Glycan distributions suggest evolution optimizes glycoprotein surface coverage