Claisen–Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)‐2‐oxo‐N,4,6‐triarylcyclohex‐3‐enecarboxamide derivatives with different substituents in H<sub>2</sub>O/EtOH

Mousavi, Seyyed Rasul

doi:10.1002/chir.22653

Cited by 8 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For the synthesis of the two chalcones, a Claisen-Schmidt condensation reaction under basic conditions between 2-acetylpyridine A1 or 2-acetyl-6-methylpyridine A2 and aldehyde A3 was carried out (See Scheme 1 ) [ 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ].…”

Section: Resultsmentioning

confidence: 99%

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

et al. 2022

View full text Add to dashboard Cite

This work is devoted to the study of two copper complexes (Cu) bearing pyridine ligands, which were synthesized, evaluated and tested as new visible light photoinitiators for the free radical photopolymerization (FRP) of acrylates functional groups in thick and thin samples upon light-emitting diodes (LED) at 405 and 455 nm irradiation. These latter wavelengths are considered to be safe to produce polymer materials. The photoinitiation abilities of these organometallic compounds were evaluated in combination with an iodonium (Iod) salt and/or amine (e.g., N-phenylglycine—NPG). Interestingly, high final conversions and high polymerization rates were obtained for both compounds using two and three-component photoinitiating systems (Cu1 (or Cu2)/Iodonium salt (Iod) (0.1%/1% w/w) and Cu1 (or Cu2)/Iod/amine (0.1%/1%/1% w/w/w)). The new proposed copper complexes were also used for direct laser write experiments involving a laser diode at 405 nm, and for the photocomposite synthesis with glass fibers using a UV-conveyor at 395 nm. To explain the obtained polymerization results, different methods and characterization techniques were used: steady-state photolysis, real-time Fourier transform infrared spectroscopy (RT-FTIR), emission spectroscopy and cyclic voltammetry.

show abstract

Section: Resultsmentioning

confidence: 99%

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Chalcones or 1,3-diphenyl-2-propen-1-ones have been proven to display a broad spectrum of pharmacological activities, including anticancer [9,10]. They are made up of two benzene rings with a diverse array of substituents which are interconnected by a highly electrophilic threecarbon α,β-unsaturated carbonyl system, as shown in Figure 1 [11,12].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Cytotoxicity Study and Docking Studies of New Fused-pyrazoline Derivatives derived from Bis-Chalcones Against Breast Cancer cells

et al. 2021

View full text Add to dashboard Cite

Breast cancer is one of the prevalent diseases that kill millions of women worldwide. The development of resistance and side effects of chemotherapy drugs is a common obstacle in the treatment of breast cancer. Recently, the focus of drug discovery has increased toward a valuable structure known as chalcones due to their extensive bioactivity in cancer treatment. In this study, 6 chalcones and 4 fused-pyrazoline derivatives have been synthesized (1-6) using the Claisen-Schmidt condensation technique for cyclopentanone and cyclohexanone with different aromatic aldehydes at room temperature. Chalcones 2-3 and 5-6 were used in cyclo-condensation reaction with thiosemicarbazide to form new fused pyrazoline derivatives. All the synthesized chalcones and fused pyrazoline were characterized using ATR-FTIR, H-NMR and 13 C-NMR (1D ). The cytotoxic activity of these new chalcone compounds was investigated against breast cancer cell lines (MCF-7) and normal breast cell lines (MCF-10A). The results showed that compounds 1 and 10 exhibited significant antiproliferative effects against MCF-7 with IC50 values of 8 µM and 8.5 µM when exposed for 48 hours compared with the reference anticancer drug, tamoxifen. Molecular docking analysis showed that compounds 1 and 10 entered the pocket of ERα and interaction with the amino acids in high affinity of binding as tamoxifen.

show abstract

Graphene Oxide Incorporated Strontium Nanoparticles as a Highly Efficient and Green Acid Catalyst for One-Pot Synthesis of Tetramethyl-9-aryl-hexahydroxanthenes and 13-Aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones Under Solvent-Free Conditions

Mousavi

Nodeh²,

Afshari

et al. 2019

Catal Lett

View full text Add to dashboard Cite

Claisen–Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)‐2‐oxo‐N,4,6‐triarylcyclohex‐3‐enecarboxamide derivatives with different substituents in H₂O/EtOH

Cited by 8 publications

References 67 publications

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Synthesis, Characterization, Cytotoxicity Study and Docking Studies of New Fused-pyrazoline Derivatives derived from Bis-Chalcones Against Breast Cancer cells

Graphene Oxide Incorporated Strontium Nanoparticles as a Highly Efficient and Green Acid Catalyst for One-Pot Synthesis of Tetramethyl-9-aryl-hexahydroxanthenes and 13-Aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones Under Solvent-Free Conditions

Contact Info

Product

Resources

About

Claisen–Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)‐2‐oxo‐N,4,6‐triarylcyclohex‐3‐enecarboxamide derivatives with different substituents in H2O/EtOH

Cited by 8 publications

References 67 publications

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Novel Copper Complexes as Visible Light Photoinitiators for the Synthesis of Interpenetrating Polymer Networks (IPNs)

Synthesis, Characterization, Cytotoxicity Study and Docking Studies of New Fused-pyrazoline Derivatives derived from Bis-Chalcones Against Breast Cancer cells

Graphene Oxide Incorporated Strontium Nanoparticles as a Highly Efficient and Green Acid Catalyst for One-Pot Synthesis of Tetramethyl-9-aryl-hexahydroxanthenes and 13-Aryl-5H-dibenzo[b,i]xanthene-5,7,12,14(13H)-tetraones Under Solvent-Free Conditions

Contact Info

Product

Resources

About

Claisen–Schmidt condensation: Synthesis of (1S,6R)/(1R,6S)‐2‐oxo‐N,4,6‐triarylcyclohex‐3‐enecarboxamide derivatives with different substituents in H₂O/EtOH