Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs)

Bourebaba, Lynda; Michalak, Izabela; Röcken, Michael; Marycz, Krzysztof

doi:10.1016/j.biopha.2018.12.020

Cited by 27 publications

(16 citation statements)

References 53 publications

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“…After exposure to C. glomerata extract, we found obvious increased mitochondrial membrane potentiation, as well as high MitoRed fluorescent signal corresponding to increased number of active mitochondria. These results indicate that algal extract caused a significant improvement of cellular mitochondria function, which is in accordance with our previous finding 19,25. One of the supposed mechanisms by which the algae extract could exert effect on the maintenance of the mitochondrial integrity, lies in the potential of the latter to modulate positively and to potentiate the transcription of the Bcl-2 cell survival gene, which would restore the protective effect of that factor on mitochondria.Recent reports have suggested that LPS stimulates the intracellular ROS production within the cells through the activation of NADPH oxidase.…”

supporting

confidence: 92%

“…30 are known to be prone to significant apoptosis. 19,25 Recent studies have elucidated that normal mitochondrial function is importantly required for osteogenic differentiation, and its dysfunction has already been associated with impaired osteogenesis. [33][34][35] The toxic effect produced by LPS was demonstrated to be closely associated with mitochondrial dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…18 As one of the most common and important filamentous green algae in freshwater, Cladophora glomerata or commonly known as 'cotton-mat' or 'blanket weed' is attracting more and more attention not only because of its high nutritional value, but also because of its richness in various secondary metabolites giving it a high potential in therapeutics for the treatment of among others inflammation, oxidative stress and infectious diseases. 19,20 Recently, the concept of mutual potentiation of the therapeutic and physiological effects of natural substrates and trace elements has been introduced and is part of the new innovative perspectives in therapeutics. Thus, biosorption process can be applied in order to improve the bioavailability of the microelements for the animals while combining the nutritional and curative properties of the used biomasses.…”

Section: Introductionmentioning

confidence: 99%

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Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis

Bourebaba

Michalak

Baouche

et al. 2020

J Cellular Molecular Medi

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supporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis

Bourebaba

Michalak

Baouche

et al. 2020

J Cellular Molecular Medi

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“…2015; Bourebaba et al . 2019). Among other lipid compounds found in marine and freshwater Cladophora , steroids deserve attention.…”

Section: Biochemical Composition Of Cladophora Sppmentioning

confidence: 99%

“…2018; Bourebaba et al . 2019), C. rupestris (Krish & Das 2014; Unnikrishnan et al . 2015; Marycz et al .…”

Section: Physiological and Therapeutic Effects Of Cladophora Biomass mentioning

confidence: 99%

Is biomass of filamentous green algae Cladophora spp. (Chlorophyta, Ulvophyceae) an unlimited cheap and valuable resource for medicine and pharmacology? A review

Празукин

Anufriieva

Shadrin

2020

Reviews in Aquaculture

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Filamentous green algae Cladophora spp. are cosmopolitans inhabiting waters with different salinity, from freshwater to hypersaline. Eutrophication of marine and inland waters results in the huge development of filamentous green algae, which reach high biomass and occupy large areas in different water bodies. This leads to the strong negative effect on the species richness of communities, significantly reduces the aesthetic value of coastal waters, hampers the recreational use of beaches and the coastline, and complicates industrial water intake and coastal fishing. Harvesting and the use of Cladophora biomass can be an effective tool to remediate eutrophic waters. Cladophora spp. are also among the most promising subjects to use in the development of integrated multi‐trophic aquaculture; there is a big potential to use it. Aquaculture is one of the potential uses. To plan the use of a resource, business needs to know the availability and quantity of the resource, the price of the resource, as well as for what benefit and how it can be used. This review summarizes and analyses existing data to answer these questions. Cladophora biomass can be used for food for humans, livestock, cultivated fish and shrimps, as fertilizers, in the energy sector (biogas and biodiesel), and different industries. The use of Cladophora in medicine and pharmacology is one of the most profitable promising ways to utilize the biomass. This review shows that Cladophora biomass is an unlimited, low cost and valuable resource for medicine and pharmacology.

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Hepatoprotective role of myricitrin isolated from Mimusops elengi Linn. leaves extract on γ‐radiation‐induced liver damage in rats: Phyto‐biochemical investigations

Sayed

Mohamed

Nada

et al. 2023

Cell Biochemistry & Function

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The hepatoprotective effects of methanol extract of Mimusops elengi Linn. (M. elengi L.) leaves and isolated pure myricitrin (3‐, 4‐, 5‐, 5, 7‐five hydroxyflavone‐3‐O‐α‐l‐rhamnoside) (Myr) were evaluated in male rats exposed to γ‐irradiation. The extraction of M. elengi L. leaves was performed using ethyl acetate (EtOAC). Seven groups of rats were used: control group, irradiated (IRR) group (6 Gy of γ‐rays in a single dose), vehicle group (oral administration of 0.5% carboxymethyl cellulose for 10 days), EtOAC extract group (100 mg/kg body weight of extract, orally for 10 days), EtOAC + IRR group (administration of extract and exposure to γ‐rays on Day 7), Myr group (50 mg/kg body weight Myr, orally for 10 days), and Myr + IRR group (administration of Myr and exposure to γ‐rays on Day 7). High‐performance liquid chromatography and 1H‐nuclear magnetic resonance were used to isolate and characterize the compounds from M. elengi L. leaves. Enzyme‐linked immunosorbent assay was used for biochemical analyses. Identified compounds were Myr, myricetin 3‐O‐galactoside, myricetin 3‐O‐rahmnopyranoside (1 → 6) glucopyranoside, quercetin, quercitol, gallic acid, α‐,β‐amyrin, ursolic acid, and lupeol. Serum aspartate transaminase and alanine transaminase activities were significantly increased, while serum protein and albumin levels were significantly decreased after irradiation. Hepatic levels of tumor necrosis factor‐α, prostaglandin 2, inducible nitric oxide synthase, interleukin‐6 (IL‐6), and IL‐12 were increased following irradiation. Improvements were observed in most serological parameters after treatment with extract or pure Myr, with histological analyses confirming decreased liver injury in treated rats. Our study demonstrates that pure Myr has a greater hepatoprotective effect than M. elengi leaf extracts against irradiation‐induced hepatic inflammation.

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Cladophora glomerata methanolic extract decreases oxidative stress and improves viability and mitochondrial potential in equine adipose derived mesenchymal stem cells (ASCs)

Cited by 27 publications

References 53 publications

Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis

Cladophora glomerata enriched by biosorption with Mn(II) ions alleviates lipopolysaccharide‐induced osteomyelitis‐like model in MC3T3‐E1, and 4B12 osteoclastogenesis

Is biomass of filamentous green algae Cladophora spp. (Chlorophyta, Ulvophyceae) an unlimited cheap and valuable resource for medicine and pharmacology? A review

Hepatoprotective role of myricitrin isolated from Mimusops elengi Linn. leaves extract on γ‐radiation‐induced liver damage in rats: Phyto‐biochemical investigations

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