Cladielloides C and D: Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral <i>Cladiella</i> sp.

Tai, Chia Ying; Chen, Yung Husan; Hwang, Tsong‐Long; Fang, Lee Shing; Wang, Wei Hsien; Liu, Ming Chin; Su, Jui Hsin; Wu, Yang Chang; Sung, Ping Jyun

doi:10.1246/bcsj.20100348

Cited by 14 publications

(6 citation statements)

References 37 publications

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“…Also, compounds 1 , 4 and 5 exhibited moderate to weak cytotoxicity toward CCRF-CEM and MOLT 4 cell lines. Besides our research, many recent studies have showed the versatile structures and bioactivities of eunicellin-type compounds [16,17,18,19,20,21]. These studies along with the new simplexins described here suggest that eunicellin-type compounds, in particular 3, are worthy of further biomedical investigation.…”

Section: Methodssupporting

confidence: 60%

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Huang

et al. 2012

Marine Drugs

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Four new eunicellin-based diterpenes, simplexins P–S (1–4), and the known compound simplexin A (5), have been isolated from the soft coral Klyxum simplex. The structures of the new metabolites were determined on the basis of extensive spectroscopic analysis, particularly 1D and 2D NMR experiments. Compounds 1 and 3–5 were shown to exhibit cytotoxicity against a limited panel of cancer cell lines, 3 being the most cytotoxic.

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Section: Methodssupporting

confidence: 60%

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Huang

et al. 2012

Marine Drugs

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“…Therefore, the current primary issues in marine conservation, such as the loss of biodiversity through over-exploitation and habitat degradation, can be overcome. Additional information can be found in the Supplementary Materials [95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,…”

Section: Discussionmentioning

confidence: 99%

Marine Natural Products from Indonesian Waters

et al. 2019

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Natural products are primal and have been a driver in the evolution of organic chemistry and ultimately in science. The chemical structures obtained from marine organisms are diverse, reflecting biodiversity of genes, species and ecosystems. Biodiversity is an extraordinary feature of life and provides benefits to humanity while promoting the importance of environment conservation. This review covers the literature on marine natural products (MNPs) discovered in Indonesian waters published from January 1970 to December 2017, and includes 732 original MNPs, 4 structures isolated for the first time but known to be synthetic entities, 34 structural revisions, 9 artifacts, and 4 proposed MNPs. Indonesian MNPs were found in 270 papers from 94 species, 106 genera, 64 families, 32 orders, 14 classes, 10 phyla, and 5 kingdoms. The emphasis is placed on the structures of organic molecules (original and revised), relevant biological activities, structure elucidation, chemical ecology aspects, biosynthesis, and bioorganic studies. Through the synthesis of past and future data, huge and partly undescribed biodiversity of marine tropical invertebrates and their importance for crucial societal benefits should greatly be appreciated.

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“…The anti‐inflammatory evaluations in vitro showed diterpenoid 124 significant inhibits the production of superoxide anion and the release of elastase by human neutrophils with IC 50 =5.9±0.7, 6.5±1.9 μg/mL, respectively. Their continuous study on this organism afforded two novel eunicellin‐type diterpenoids, namely cladielloides C ( 125 ) and D ( 126 ) [51] . It was worth noting that the structure of 125 furnished the additional ether bridge between C‐3 and C‐6 as a part of a hemiketal constellation, and 106 was the second example of 6,7‐secoeunicellin.…”

Section: Marine Natural Products From the Genus Of Cladiellamentioning

confidence: 99%

Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties

Liang

Guo

2022

Chemistry & Biodiversity

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Marine octocorals belonging to the genus Cladiella, usually encountered on reefs in the Indo-Pacific region, have been proven to be rich sources of diverse secondary metabolites with intriguing structural features and promising bioactivities. In this review, 155 compounds from six unambiguously identified C. krempfi, C. australis, C. pachyclados, C. hirsuta, C. tuberculosa, C. conifera, together with several unidentified Cladiella spp. are summarized covering the literatures from 2006 to August 2022. It is noteworthy that diterpenoids dominated the secondary metabolite profile of this genus counting for 78 %. Structurally, the majority of these diterpenes belonged to eunicellan family characterized by different patterns of ether linkage. The impacts of these chemical compositions on an array of potential pharmacological activities were also reviewed, giving an overview of the potential application of Cladiella secondary metabolites.

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Cladielloides C and D: Novel Eunicellin-Based Diterpenoids from an Indonesian Octocoral Cladiella sp.

Cited by 14 publications

References 37 publications

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Simplexins P–S, Eunicellin-Based Diterpenes from the Soft Coral Klyxum simplex

Marine Natural Products from Indonesian Waters

Cladiella Octocorals: Enormous Sources of Secondary Metabolites with Diverse Structural and Biological Properties

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