CKD in Patients with Bilateral Oophorectomy

Kattah, Andrea; Smith, Carin Y.; Rocca, Liliana Gazzuola; Grossardt, Brandon R.; Garovic, Vesna D.; Rocca, Walter A.

doi:10.2215/cjn.03990318

Cited by 34 publications

(18 citation statements)

References 46 publications

(53 reference statements)

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“…Utilizing a novel approach to address the issue of sex and CKD progression, Kattah et al 48 matched 1653 women who underwent bilateral oophorectomy before age 50 years with women whose ovaries were intact and found that the incidence of CKD, over a median follow-up of 14 years, was greater in those with surgical menopause (adjusted hazard ratio, 1.42). The risk of CKD was also related to whether the women received estrogen therapy and to the duration of such therapy.…”

Section: Sexual Dimorphism In the Progres-sion Of Chronic Kidney Diseasementioning

confidence: 99%

Influence of Sex on the Progression of Chronic Kidney Disease

Neugarten

Golestaneh

2019

Mayo Clinic Proceedings

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The role that sex plays in the development and progression of chronic kidney disease remains a subject of controversy. The lack of clarity in this important area reflects complex interactions between biological factors and cultural and socioeconomic influences that impact the relationship between sex and renal disease. Certainly, additional observational studies are indicated; however, innovative approaches are required to isolate biological processes from cultural influences. Despite these limitations, available data suggest that the progression of renal disease is slower in women than in men and that this sexual dimorphism is primarily due to direct actions of sex hormones on cellular metabolism. The extent to which differences in lifestyle factors between the sexes influence sexual dimorphism in the progression of chronic kidney disease remains to be elucidated.

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Section: Sexual Dimorphism In the Progres-sion Of Chronic Kidney Diseasementioning

confidence: 99%

Influence of Sex on the Progression of Chronic Kidney Disease

Neugarten

Golestaneh

2019

Mayo Clinic Proceedings

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“…This process is presumed to have led to the emergence of a number of complications, such as hot flashes (or vasomotor symptoms), chronic kidney disease (CKD), cardiovascular disease, and neurodegenerative disease ( Schindler et al, 2009 ; Torres et al, 2017 ) ( Williamson et al, 2019 ). Of those conditions, a common comorbidity in women with menopause is closely linked to the process of CKD development, which increases mortality ( Kattah et al, 2018 ; Vellanki and Hou, 2018 ). Although endogenous estrogen plays a critical role in the protection of renal function, the initiation of hormone replacement therapy (HRT) is recommended to stop or reverse this decline.…”

Section: Introductionmentioning

confidence: 99%

Hypericum perforatum L. Regulates Glutathione Redox Stress and Normalizes Ggt1/Anpep Signaling to Alleviate OVX-Induced Kidney Dysfunction

et al. 2021

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Menopause and associated renal complications are linked to systemic redox stress, and the causal factors remain unclear. As the role of Hypericum perforatum L. (HPL) in menopause-induced kidney disease therapy is still ambiguous, we aim to explore the effects of HPL on systemic redox stress under ovariectomy (OVX)-induced kidney dysfunction conditions. Here, using combined proteomic and metabolomic approaches, we constructed a multi-scaled “HPL-disease-gene-metabolite” network to generate a therapeutic “big picture” that indicated an important link between glutathione redox stress and kidney impairment. HPL exhibited the potential to maintain cellular redox homeostasis by inhibiting gamma-glutamyltransferase 1 (Ggt1) overexpression, along with promoting the efflux of accumulated toxic amino acids and their metabolites. Moreover, HPL restored alanyl-aminopeptidase (Anpep) expression and metabolite shifts, promoting antioxidative metabolite processing, and recovery. These findings provide a comprehensive description of OVX-induced glutathione redox stress at multiple levels and support HPL therapy as an effective modulator in renal tissues to locally influence the glutathione metabolism pathway and subsequent redox homeostasis.

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“…A recent cohort study of women who underwent bilateral oophorectomy before the onset of menopause revealed that the risk for incident CKD was higher vs in an agematched group that did not undergo oophorectomy, suggesting that the premature depletion of endogenous estrogen due to surgical procedures could accelerate the deterioration in kidney function. 26 However, observational studies evaluating the effect of Odds ratio…”

Section: Discussionmentioning

confidence: 99%

Association of Reproductive Lifespan Duration and Chronic Kidney Disease in Postmenopausal Women

Kang

Jhee

Joo

et al. 2020

Mayo Clinic Proceedings

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Objective: To investigate the relationship between endogenous estrogen exposure and renal function, the association of female reproductive life span duration (RLD) and chronic kidney disease (CKD) was analyzed in postmenopausal women. Patients and Methods: Data were retrieved from the Korean Genome and Epidemiology Study, which was constructed from May 1, 2001, through December 25, 2017. A total of 50,338 and 3155 postmenopausal women were each included in the cross-sectional and longitudinal analyses. The RLD was determined by subtracting the age at menarche from the age at menopause. Participants were grouped into RLD quartiles. Participants with estimated glomerular filtration rates less than 60 mL/min/1.73 m 2 were regarded to have CKD. Results: In the cross-sectional analysis, mean AE SD age and estimated glomerular filtration rate were 56.3AE4.9 years and 93.1AE13.6 mL/min/1.73 m 2 , respectively. Mean AE SD RLD was 34.2AE4.0 years. A total of 765 of 50,338 (1.52%) women were found to have CKD. Logistic regression analysis revealed that the odds ratio for CKD was lower in groups with longer RLDs as compared with the shortest RLD group. In longitudinal analysis, postmenopausal women with normal kidney function were followed up for 9.7 years and incident CKD occurred in 221 of 3155 (7.00%) participants. Cox analysis revealed that the risk for CKD development was significantly lower in longer RLD groups. This finding was significant even after adjustments for confounding factors. Conclusion: The risk for CKD was lower in women with longer RLDs. The amount of endogenous estrogen exposure could be a determining factor for renal function in postmenopausal women.

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CKD in Patients with Bilateral Oophorectomy

Abstract: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_10_11_CJASNPodcast_18_1.

Cited by 34 publications

References 46 publications

Influence of Sex on the Progression of Chronic Kidney Disease

Influence of Sex on the Progression of Chronic Kidney Disease

Hypericum perforatum L. Regulates Glutathione Redox Stress and Normalizes Ggt1/Anpep Signaling to Alleviate OVX-Induced Kidney Dysfunction

Association of Reproductive Lifespan Duration and Chronic Kidney Disease in Postmenopausal Women

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