CKD and Mortality Risk in Older People: A Community-Based Population Study in the United Kingdom

Roderick, Paul; Atkins, Richard J.; Smeeth, Liam; Mylne, Adrian; Nitsch, Dorothea; Hubbard, Richard; Bulpitt, Christopher J.; Fletcher, Astrid

doi:10.1053/j.ajkd.2008.12.036

Cited by 140 publications

(104 citation statements)

References 41 publications

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“…The relationship between CKD and mortality is well described, and this relationship extends to older patients 14,15 . Debate continues as to whether CKD, especially less severe CKD (e.g.…”

Section: Discussionmentioning

confidence: 99%

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation

Doyle

Sloan

Goodbrand

et al. 2015

American Journal of Kidney Diseases

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“…The relationship between CKD and mortality is well described, and this relationship extends to older patients 14,15 . Debate continues as to whether CKD, especially less severe CKD (e.g.…”

Section: Discussionmentioning

confidence: 99%

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation

Doyle

Sloan

Goodbrand

et al. 2015

American Journal of Kidney Diseases

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“…CKD is a well established predictor of all-cause and cardiovascular mortality (1,2), hospitalization (2), and disability (3)(4)(5)(6). Within the Medicare and dually enrolled Medicare-Medicaid population, persons with CKD have increased rates of hospitalization, particularly for heart failure and infections compared with persons without CKD (5).…”

Section: Introductionmentioning

confidence: 99%

“…Within the Medicare and dually enrolled Medicare-Medicaid population, persons with CKD have increased rates of hospitalization, particularly for heart failure and infections compared with persons without CKD (5). Additionally, the average length of stay is longer for patients hospitalized with a diagnosis of CKD than for any other disease category (7).…”

Section: Introductionmentioning

confidence: 99%

Risks of Subsequent Hospitalization and Death in Patients with Kidney Disease

Daratha

Short

Corbett

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Rates of hospitalization are known to be high in patients with kidney disease. However, ongoing risks of subsequent hospitalization and mortality are uncertain. The primary objective was to evaluate patients with kidney disease for long-term risks of subsequent hospitalization, including admissions resulting in death. (n=6131), kidney transplant (n=1100), and reference (n=641,242) cohorts. Cox proportional hazard models controlling for age, sex, payer, comorbidity, previous hospitalization, primary diagnosis category, and length of stay were conducted for time to event analyses.Results Compared with the reference cohort, risks for subsequent hospitalization were increased in the CKD (hazard ratio=1.20, 99% confidence interval=1.18-1.23, P,0.001), dialysis (hazard ratio=1.76, 99% confidence interval=1.69-1.83, P,0.001), and kidney transplant (hazard ratio=1.85, 99% confidence interval=1.68-2.03, P,0.001) cohorts, with a mean follow-up time of 29 months. Similarly, risks for fatal hospitalization were increased for patients in the CKD (hazard ratio=1.41, 99% confidence interval=1.34-1.49, P,0.001), dialysis (hazard ratio=3.04, 99% confidence interval=2.78-3.31, P,0.001), and kidney transplant (hazard ratio=2.25, 99% confidence interval=1.67-3.03, P,0.001) cohorts. Risks for hospitalization and fatal hospitalization increased in a graded manner by CKD stage.Conclusions Risks of subsequent hospitalization, including admission resulting in death, among patients with kidney disease were substantially increased in a large statewide population. Patients with kidney disease should be a focus of efforts to reduce hospitalizations and mortality.

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“…Previous studies have demonstrated that CKD increases the risks of cardiovascular morbidity and mortality (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The prevalence of CKD has been shown to be high in population studies (10% to 13%) (14 -16), and for CKD patients in the general population, the risk of death, particularly due to cardiovascular disease (CVD), is much higher than that of ESRD requiring renal replacement therapy (RRT) (12)(13).…”

mentioning

confidence: 99%

Impact of Age and Overt Proteinuria on Outcomes of Stage 3 to 5 Chronic Kidney Disease in a Referred Cohort

Obi

Kimura

Nagasawa

et al. 2010

Clinical Journal of the American Society of Nephrology

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Results: The median age of subjects was 67.0 years, and median follow-up was 3.2 years. Overt proteinuria was present in 57.0% of subjects. For stage 3, 4, and 5 CKD, cumulative mortality and probability of ESRD at 3 years was 9.5 and 6.5%, 11.2 and 27.8%, and 16.5 and 79.1%, respectively. Using proportional-hazards regression models, age was a determinant for death, whereas overt proteinuria was strongly associated with ESRD. Among stage 3 CKD patients older than 65 years without overt proteinuria, the incidence of death before renal replacement therapy (RRT) was 2.8/100 patient-years and none had ESRD. In patients with advanced CKD and overt proteinuria, the incidence of ESRD was substantially higher than that of death before RRT.Conclusions: Stratification by age, proteinuria level, and CKD stage could predict the competing outcomes of death before RRT and ESRD among CKD patients.

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CKD and Mortality Risk in Older People: A Community-Based Population Study in the United Kingdom

Cited by 140 publications

References 41 publications

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation

Association Between Kidney Function, Rehabilitation Outcome, and Survival in Older Patients Discharged From Inpatient Rehabilitation

Risks of Subsequent Hospitalization and Death in Patients with Kidney Disease

Impact of Age and Overt Proteinuria on Outcomes of Stage 3 to 5 Chronic Kidney Disease in a Referred Cohort

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