Abstract:1242
Interleukin 7 (IL-7) and its receptor (IL-7R) are essential for normal T-cell development and homeostasis. However, IL-7/IL-7R-mediated signaling may also partake in leukemia development, as we recently demonstrated by the identification of IL-7Rα gain-of-function mutations in around 9% of T-cell acute lymphoblastic leukemia (T-ALL) patients (Zenatti et al, Nat Genet 2011). Moreover, we have shown that IL-7 produced in the leukemia milieu by stromal cells can accelerate leukemia progression… Show more
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