CK2 activity is crucial for proper glucagon expression
Emmanuel Ampofo,
Mandy Pack,
Selina Wrublewsky
et al.
Abstract:Aims/hypothesis
Protein kinase CK2 acts as a negative regulator of insulin expression in pancreatic beta cells. This action is mainly mediated by phosphorylation of the transcription factor pancreatic and duodenal homeobox protein 1 (PDX1). In pancreatic alpha cells, PDX1 acts in a reciprocal fashion on glucagon (GCG) expression. Therefore, we hypothesised that CK2 might positively regulate GCG expression in pancreatic alpha cells.
Methods
We suppressed CK… Show more
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