CK/CK-MB ratio as an indirect predictor for survival in polytraumatized patients

Kovar, Florian M.; Aldrian, Silke; Endler, Georg; Vécsei, V.; Hajdu, Stefan; Heinz, Thomas; Wagner, Oswald

doi:10.1007/s00508-012-0155-8

Cited by 4 publications

(15 citation statements)

References 33 publications

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“…In addition, the overall mortality showed an obvious downward trend with the extension of the follow-up period, especially after 20 months. We speculated that elevated CK-MB might re ect damage to internal organs, which appears to be consistent with the ndings of Kovar FM et al [4] .…”

Section: Discussionsupporting

confidence: 91%

“…Patients with elevated CK-MB had increased in-hospital as well as overall mortality. Similar results were also reported by Kovar FM [4] and Karakus A [20] .…”

Section: Discussionsupporting

confidence: 90%

“…Moreover, an elevated serum level of CK-MB is associated with poor prognosis of COVID-19 [9,10] and provides a predictive value for contrast-induced acute kidney injury among myocardial infarction patients [11] . In addition, studies have also found that CK-MB is associated with the in-hospital mortality of polytrauma patients [4,12] . However, due to the limitations of the above studies, the association between serum CK-MB levels and short-term prognosis and long-term prognosis in polytrauma patients with nonmyocardial contusion remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Approximately 5.8 million deaths are caused by trauma every year, among which the mortality rate of severe trauma patients can reach 8.5% [3] . Recent studies have focused on potential preventable risk factors for in-hospital mortality in polytrauma patients [4,5] , including the plasma lactate level, the blood glucose level, and base excess, have been con rmed to predict the short-term prognosis in polytrauma patients [6,7] . However, there is limited research exploring risk markers and long-term survival after polytraumas.…”

Section: Introductionmentioning

confidence: 99%

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Clinical prognostic value of elevated CK-MB in severe multiple trauma patients with nonmyocardial contusion

Huang

Sun

et al. 2023

Preprint

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Background: Unintentional injury was the leading cause of death and disability among individuals younger than 49 years globally in 2019. However, the association between serum CK-MB levels and clinical value in polytrauma patients with nonmyocardial contusion remains unclear. Methods: This was a single-center, retrospective study. Demographic and clinical data were extracted from the Hospital Information System (HIS) at the Third Xiangya Hospital of Central South University. A total of 287 patients were included in the study. Patients were divided into a normal group (CK-MB ≤25 U/L) and an abnormal group (CK-MB >25 U/L) based on a low CK-MB level. Further clinical and follow- up data were analyzed by using univariate and multivariate logistic regression.Finally, disease-free survival and overall survival were calculated by the Kaplan– Meier method. Results: Multivariate logistic regression demonstrated that CK-MB (OR: 1.023, 95% CI: 1.006-1.040) was an independent risk factor for predicting in-hospital mortality in polytrauma patients with nonmyocardial contusion. Compared with normal CK-MB levels, CK-MB elevation was associated with a longer length of ICU stay (7.38±13.13 vs. 3.16±5.86 days, P =0.004) and total length of hospital stay (24.73±23.04 vs. 18.29±14.63 days, P =0.015) and was more likely to result in arrhythmia during hospitalization (19.29% vs. 10%, P =0.048). Moreover, the follow-up data showed that patients with CK-MB elevation were more likely to have cardiopalmus after discharge (15.00% vs. 5.68%, P =0.027). Conclusion: Our findings suggested that elevated CK-MB played an important role in the prognosis of polytrauma patients with nonmyocardial contusion, and a higher level of CK-MB indicated a poor prognosis.

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Section: Discussionsupporting

confidence: 91%

“…Patients with elevated CK-MB had increased in-hospital as well as overall mortality. Similar results were also reported by Kovar FM [4] and Karakus A [20] .…”

Section: Discussionsupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical prognostic value of elevated CK-MB in severe multiple trauma patients with nonmyocardial contusion

Huang

Sun

et al. 2023

Preprint

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“…When a large number of CK-BB and macro-CK exist, there may even be an abnormal situation with CK-MB to total CK ratio (CK-MB/CK) exceeding 1 [17]. According to previous studies, the most common malignant tumor with CK-MB/CK greater than 1 was CRC [13,18].…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Rao,

Zu,

Zhang

et al. 2023

Preprint

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Objectives: This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase (CK)-MB to total-CK ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods: This was a single-center retrospective cohort analysis. Subjects were stage I-III CRC patients hospitalized in Sichuan Cancer Hospital from January 2017 to May 2021. The overall survival (OS) and disease-free survival rate (DFS) were analyzed between two groups according to the serum CK-MB/CK levels after surgery. Cox regression analyses, Kaplan-Meier method, and receiver-operating characteristic (ROC) curve were performed. Results: CK-MB/CK was the strongest independent prognostic factor for OS and DFS. Compared to the normal group (n = 1177), the elevated group (n = 95) had worse OS (HR, 5.64; p < 0.0001) and DFS (HR, 8.34; p < 0.0001). For the diagnosis of hepatic metastases after surgery, the ROC area under the curve (AUC) of CK-MB/CK was 0.720 (p < 0.001). When CK-MB/CK > 1.01, the specificity was 94.84% and the negative predictive value (NPV) was 96.7%. Combined CK-MB/CK and CA19-9, the AUC value increased from 0.720 to 0.799 (p = 0.036), with a sensitivity of 77.46% and a specificity of 97.25%. Conclusions: CRC patients with elevated CK-MB/CK had a worse prognosis after radical resection. CK-MB/CK might be a new biomarker for the diagnosis of hepatic metastasis in CRC patients after surgery, with high specificity and NPV.

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Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Rao,

Xu,

Zhang

et al. 2024

BMC Cancer

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Objectives This study aimed to evaluate the prognostic significance of postoperative Creatine Kinase type M and B (CK-MB) to total Creatine Kinase (CK) ratio (CK-MB/CK) in colorectal cancer (CRC) patients after radical resection. Methods This was a single-center retrospective cohort analysis. Subjects were stage I-III CRC patients hospitalized in Sichuan Cancer Hospital from January 2017 to May 2021. Patients were divided into abnormal group and normal group according to whether the CK-MB/CK ratio was abnormal after surgery. Through a comparative analysis of clinical data, laboratory test results, and prognosis differences between the two groups, we aimed to uncover the potential relationship between abnormal CK-MB > CK results and CRC patients. To gauge the impact of CK-MB/CK on overall survival (OS) and disease-free survival (DFS), we employed the multivariable COX regression and LASSO regression analysis. Additionally, Spearman correlation analysis, logistic regression, and receiver-operating characteristic (ROC) curve analysis were conducted to assess the predictive value of the CK-MB/CK ratio for postoperative liver metastasis. Results Cox regression analysis revealed that the CK-MB/CK ratio was a stable risk factors for OS (HR = 3.82, p < 0.001) and DFS (HR = 2.31, p < 0.001). To distinguish hepatic metastases after surgery, the ROC area under the curve of CK-MB/CK was 0.697 (p < 0.001), and the optimal cut-off value determined by the Youden index was 0.347. Conclusions Postoperative abnormal CK-MB/CK ratio predicts worse prognosis in CRC patients after radical resection and serves as a useful biomarker for detecting postoperative liver metastasis.

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CK/CK-MB ratio as an indirect predictor for survival in polytraumatized patients

Cited by 4 publications

References 33 publications

Clinical prognostic value of elevated CK-MB in severe multiple trauma patients with nonmyocardial contusion

Clinical prognostic value of elevated CK-MB in severe multiple trauma patients with nonmyocardial contusion

Prognostic value of Creatine Kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

Prognostic value of creatine kinase (CK)-MB to total-CK ratio in colorectal cancer patients after curative resection

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