CJD without borders

Cunha, José Eriton Gomes da; Nascimento, Jéssica Catarine Frutuoso do; Oliveira, João Ricardo Mendes de

doi:10.1038/s41582-021-00566-w

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2023

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“…Prion diseases are fatal neurodegenerative diseases caused by the conversion of a normal, cell-surface glycoprotein (PrP C ) into a misfolded pathogenic form (PrP Sc ), which results in a wide array of degenerative neurological disorders [ 1 , 2 ]. The more stable PrP Sc (also referred to as PrP res for protease-resistance) denotes scrapie associated prion protein which are misfolded, beta-sheet-rich structures with low Gibbs free energy [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%