CJ-15,696 and Its Analogs, New Furopyridine Antibiotics from the Fungus Cladobotryum varium: Fermentation, Isolation, Structural Elucidation, Biotransformation and Antibacterial Activities.

Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938

“…6. This is reasonable in the molecular formula (C 19 H 21 NO 5 ) and the UV spectra at 207 and 233 nm, which indicated the presence of 4-hydroxy-5-phenylfuropyridine as previously reported for CJ-15,696 derivative [2]. The relative configurations of C-2, C-3, C-3Ј and C-5Ј were determined by the NOESY experiments (Fig.…”

“…All citridones showed very similar UV spectra with absorption maxima at 203ϳ207 nm and 233ϳ246 nm, suggesting the presence of phenylfuropyridone as reported by Sakemi et al [2]. Absorptions at about 1670ϳ1639 cm Ϫ1 in IR spectra suggested the presence of carbonyl groups.…”

Citridones, New Potentiators of Antifungal Miconazole Activity, Produced by Penicillium sp. FKI-1938

“…In Method A, all citridones 1) were isolated from Caldobotrium varium [9,16]. Such known ones have linked ring systems (6-6/5 or 6-6/5/6), which were different from the citridones' (6-6/5/5).…”

“…FKI-1938 also produced CJ-16,173 as described in this paper. Among the CJ compounds, CJ-15,696 was reported to possess moderate activity against various Gram-positive bacteria including some drug-resistant strains [9]. Citridones and CJ-16,173 showed no activity even at 1 mg/ml against 15 microorganisms including Gram-positive bacteria (Bacillus subtillis, Staphylococcus aureus, Mycobacterium smegmatis and Micrococcus luteus) and Gram-negative bacteria (Escherichia coli, Escherichia coli CJ-2, Xanthomonas oryzae, Pseudomonas aeruginosa, Bacteroides fragilis and Acholeplasma laidlawii), fungi (Mucor racemosus, Aspergillus niger and Pyricularia oryzae) and yeast (C. albicans and Saccharomyces cerevisiae).…”

“…1), were isolated from the culture broth of Penicillium sp. FKI-1938 along with known CJ-16,173 [9]. All citridones potentiate miconazole activity against C. albicans (wild type).…”