Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds

Ferreira, Sandrine S.; Silva, Amélia M.; Nunes, Fernando M.

doi:10.1016/j.indcrop.2017.10.009

Cited by 99 publications

(49 citation statements)

References 44 publications

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“…The mixture was incubated (1 h, room temperature), and the absorbance at 725 nm was read (PerkinElmer, Lambda 25 UV/VIS Spectrometer) [ 28 ]. Caffeic acid was used as standard and TPC was expressed as caffeic acid equivalents (mg CA eq./g lyophilized plant or mg CA eq./g extract) [ 29 , 30 ].…”

Section: Methodsmentioning

confidence: 99%

Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities

et al. 2020

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Thymus zygis subsp. zygis is an endemic Portuguese plant belonging to the Thymus zygis species. Although T. zygis is commonly used as a condiment and as a medicinal herb, a detailed description of the polyphenol composition of hydroethanolic (HE) and aqueous decoction (AD) extracts is not available. In this work, we describe for the first time a detailed phenolic composition of Thymus zygis subsp. zygis HE and AD extracts, together with their antioxidant, anti-proliferative and anti-inflammatory activities. Unlike other Thymus species, T. zygis subsp. zygis extracts contain higher amounts of luteolin-(?)-O-hexoside. However, the major phenolic compound is rosmarinic acid, and high amounts of salvianolic acids K and I were also detected. T. zygis subsp. zygis extracts exhibited significant scavenging activity of ABTS+, hydroxyl (•OH), and nitric oxide (NO) radicals. Regarding the anti-proliferative/cytotoxic effect, tested against Caco-2 and HepG2 cells, the AD extract only slightly reduced cell viability at higher concentrations (IC50 > 600 µg/mL, 48 h exposure), denoting very low toxicity, while the HE extract showed a high anti-proliferative effect, especially at 48 h exposure (IC50 of 85.01 ± 15.10 μg/mL and 82.19 ± 2.46 μg/mL, for Caco-2 and HepG2, respectively). At non-cytotoxic concentrations, both extracts reduced the nitric oxide (NO) release by lipopolysaccharide (LPS)-stimulated RAW 264.7 cells (at 50 μg/mL, HE and AD extracts inhibited NO release in ~89% and 48%, respectively). In conclusion, the results highlight the non-toxic effect of aqueous extracts, both resembling the consumption of antioxidants in foodstuff or in functional food. Furthermore, the HE extract of T. zygis subsp. zygis is a source of promising molecules with antioxidant, anti-inflammatory and anticancer activities, highlighting its potential as a source of bioactive ingredients for nutraceutical and pharmaceutical industries.

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Section: Methodsmentioning

confidence: 99%

Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities

et al. 2020

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“…In rats, the polyacetylenic compounds of Rhizoma Atractylodis macrocephalae improve delayed gastric emptying [ 68 ], and Poria activates gastric vagal nerve activity [ 69 ]. Pericarpium Citri reticulatae could regulate qi and also treat indigestion [ 70 , 71 ]. Rhizoma Pinelliae praeparatum shows dose-dependent effects on bile acid transporters in mice with hepatic injury [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Mai

Huang

et al. 2020

Open Life Sciences

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This study investigated the anti-fibrotic effects of reversine and Chinese medicine Xiang–Sha–Liu–Jun–Zi decoction (XSLJZD) on thioacetamide (TAA)-induced hepatic injury. Sprague-Dawley rats were intraperitoneally administered with TAA, then injected with reversine intraperitoneally, and/or orally provided with XSLJZD. TAA resulted in liver injury with increases in the liver index and levels of serum aspartate aminotransferase (AST) and alanine aminotransferase. Reversine alleviated the liver index and AST level and improved TAA-induced pathological changes but decreased TAA-induced collagen deposition, and α-smooth muscle actin and transforming growth factor-β1 expression. Reversine also modulated the mRNA levels of inflammatory cytokines, such as RelA, interleukin (IL)-17A, IL-22, IL-1β, IL-6, NLR family pyrin domain containing 3, platelet-derived growth factor, and monocyte chemoattractant protein, and suppressed nuclear factor (NF)-κB (p65) phosphorylation and caspase 1 activation. Meanwhile, XSLJZD protected TAA-injured liver without increasing fibrosis and enhanced the regulating effect of reversine on RelA, IL-17A, IL-1β, and MCP-1 cytokines. In conclusion, reversine ameliorates liver injury and inhibits inflammation reaction by regulating NF-κB, and XSLJZD protects the liver through its synergistic effect with reversine on regulating inflammatory cytokines.

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“…An example is limonene and terpineol extraction, which are valuable chemicals as fragrances, solvents, and chemical intermediates [ 1 ]. Another example is the extraction of compounds such as pectin, polyphenolic, and flavonoid compounds from orange peel, mainly of the Citrus sinensis variety, for nutraceutical and pharmaceutical applications [ 3 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Optical Characterization of Citrus aurantium Derived Biochar for Solar Absorber Applications

et al. 2021

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Agro-industrial waste valorization is an attractive approach that offers new alternatives to deal with shrinkage and residue problems. One of these approaches is the synthesis of advanced carbon materials. Current research has shown that citrus waste, mainly orange peel, can be a precursor for the synthesis of high-quality carbon materials for chemical adsorption and energy storage applications. A recent approach to the utilization of advanced carbon materials based on lignocellulosic biomass is their use in solar absorber coatings for solar-thermal applications. This study focused on the production of biochar from Citrus aurantium orange peel by a pyrolysis process at different temperatures. Biochars were characterized by SEM, elemental analysis, TGA-DSC, FTIR, DRX, Raman, and XPS spectroscopies. Optical properties such as diffuse reflectance in the UV−VIS−NIR region was also determined. Physical-chemical characterization revealed that the pyrolysis temperature had a negative effect in yield of biochars, whereas biochars with a higher carbon content, aromaticity, thermal stability, and structural order were produced as the temperature increased. Diffuse reflectance measurements revealed that it is possible to reduce the reflectance of the material by controlling its pyrolysis temperature, producing a material with physicochemical and optical properties that could be attractive for use as a pigment in solar absorber coatings.

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Citrus reticulata Blanco peels as a source of antioxidant and anti-proliferative phenolic compounds

Cited by 99 publications

References 44 publications

Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities

Thymus zygis subsp. zygis an Endemic Portuguese Plant: Phytochemical Profiling, Antioxidant, Anti-Proliferative and Anti-Inflammatory Activities

Reversine and herbal Xiang–Sha–Liu–Jun–Zi decoction ameliorate thioacetamide-induced hepatic injury by regulating the RelA/NF-κB/caspase signaling pathway

Physicochemical and Optical Characterization of Citrus aurantium Derived Biochar for Solar Absorber Applications

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