Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters

Li, Rachel; Theriault, André; Au, Karen K. W.; Douglas, Teresa D.; Casaschi, Adele; Kurowska, Elzbieta M.; Mukherjee, Rinee

doi:10.1016/j.lfs.2006.01.023

Cited by 135 publications

(81 citation statements)

References 31 publications

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“…Citrus flavonoids have been shown to inhibit adipogenesis and to decrease adiposity which can be explained in part by regulating the PPAR expression levels both in vivo and in vitro [38,39]. The result in the present study showed that the expression amount of PPARγ in white adipose tissue in the high doses of aloe flavonoids treated group(HDG) significantly increased as compared with what in the positive group, indicating that normal expression of PPARγ in adipose tissue was critical for prevention of blood lipid levels in hyperlipidemia, this result consistent with previous findings that suppressing PPARγ-activity can inhibit adipocyte differentiation in vitro [40], and other result showed that citrus polymethoxylated flavonoids improve lipid and glucose homeostasis through regulating the expression of PPARα and PPARγ [41]. Although compared with the model group, the PPARγ mRNA expression in the Aloe flavonoids treatment groups were not significantly increased, it still showed an increase tendency in our study, and the high dose Aloe flavonoids have the better effect on the gene of PPARγ.…”

Section: Discussionsupporting

confidence: 87%

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li¹,

Kehui²,

Jiaoying³

et al. 2014

JFNR

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Aloe flavonoids exhibit various biological activities. The aim of this study was conducted to evaluate antioxidant activity and the hypolipemic mechanism of aloe flavonoids in mice. 80 hyperlipidemic mice were divided into 5 groups, each group was oral administrated with water, 4 mg/kg·BW simvastatin, 100, 200, 300 mg/kg·BW aloe flavonoids per day, respectively. Meanwhile, 16 normal mice were used as blank control, and oral administrated with water per day. After 8 weeks intervention, the concentrations of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) in the adipose and liver tissues were evaluated. Also, hormone-sensitive lipase (HSL), peroxisome proliferator-actived receptor gamma (PPAR-γ), adipose triacylglyceride lipase (ATGL), and fatty acid synthase (FAS) genes expressions in the two tissues were detected by Q-PCR. The results showed that aloe flavonoids could decrease the TC, TG levels in the adipose and liver, while the levels of T-AOC, CAT, GSH-Px were significanly increased when compared to the control group. After treating with aloe flavonoids, the gene expressions of HSL, PPARγ and ATGL expression enhanced, but the gene expression of FAS decreased when compared to the control group. In conclusion, our data showed that aloe flavonoids have potent hypolipemic and antioxidant activities.

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Section: Discussionsupporting

confidence: 87%

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Li¹,

Kehui²,

Jiaoying³

et al. 2014

JFNR

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“…Previously our team had performed pilot studies to investigate the biological properties of both nobiletin and tangeretin in small-animal and human clinical trials. Results of these studies have shown significant decreases in serum triglycerides, total cholesterol, and low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels Roza et al, 2007) and increases in glucose tolerance (Li et al, 2006).…”

Section: Introductionmentioning

confidence: 98%

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Evans¹,

Sharma²,

Guthrie³

2012

Readings in Advanced Pharmacokinetics - Theory, Methods and Applications

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“…Polymethoxylated flavones are a group of highly methoxylated phenolic compounds existing widely in the natural world. Previous studies have demonstrated that an experimental diet supplemented with citrus polymethoxylated flavones ameliorated insulin resistance in a fructose-induced hamster model of insulin-resistance [17]. Moreover, nobiletin has been shown to significantly improve hyperglycaemia and insulin resistance in obese diabetic ob/ob mice [18].…”

Section: Introductionmentioning

confidence: 99%

Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase

Shen

Han

et al. 2012

Diabetologia

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Aims/hypothesis Pentamethylquercetin (PMQ) has recently been shown to have glucose-lowering properties. Here, we aimed to characterise the effectiveness and underlying mechanisms of PMQ for ameliorating metabolic disorders in vivo and vitro. Methods We generated a mouse model of obesity by neonatal administration of monosodium glutamate (MSG) and used it to assess the properties of PMQ as a treatment for metabolic disorders. We also investigated the possible underlying mechanisms of PMQ in the prevention of metabolic disorders. Results Compared with normal mice, MSG mice had metabolic disorders, including central obesity, hyperinsulinaemia, insulin resistance, hyperglycaemia, hyperlipidaemia, decreased phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC), and downregulated levels of GLUT4 in gastrocnemius muscles. In MSG mice, PMQ treatment (5, 10, 20 mg/kg daily) reduced body weight gain, waist circumference, adipose tissue mass, serum glucose, triacylglycerol and total cholesterol, while improving insulin resistance, activating AMPK and increasing ACC phosphorylation and GLUT4 abundance. In C2C12 myotubes, PMQ (10 μmol/l) increased glucose consumption by ∼65%. PMQ treatment (1-10 μmol/l) also activated AMPK, increased ACC phosphorylation and GLUT4 abundance, and upregulated the expression of some key genes involved in fatty acid oxidation. Conclusions/interpretation These findings suggest that PMQ can ameliorate metabolic disorders at least in part via stimulation of AMPK activity.

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Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters

Cited by 135 publications

References 31 publications

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Research on Anti-oxidant Activity and Hypolipemic Mechanism of Aloes Flavonoids in Mice

Bioavailability of Citrus Polymethoxylated Flavones and Their Biological Role in Metabolic Syndrome and Hyperlipidemia

Pentamethylquercetin generates beneficial effects in monosodium glutamate-induced obese mice and C2C12 myotubes by activating AMP-activated protein kinase

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