Citrus medica essential oil exhibits significant antimicrobial and antiproliferative activity

Mitropoulou, Gregoria; Fitsiou, Eleni; Spyridopoulou, Katerina; Tiptiri-Kourpeti, Angeliki; Bardouki, Haido; Vamvakias, Manolis; Panas, Panayiotis; Chlichlia, Katerina; Pappa, Aglaia; Kourkoutas, Yiannis

doi:10.1016/j.lwt.2017.05.036

Cited by 76 publications

(50 citation statements)

References 30 publications

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“…2.5.1. GC/MS Analysis GC/MS analysis was carried out in a GC-MS (GC: 6890A, Agilent Technologies, USA; MSD: 5973, Agilent Technologies) using a Factor Four VF 1ms column (25 m, 0.2 mm i.d., 0.33 µm film thickness, Agilent Technologies), as described previously [10]. Identification was based on the comparison of the retention times and mass spectra of the volatile compounds to Willey/NIST 0.5 and in-house created libraries, as well as on the determination of kovats' retention indexes (KI) and comparison with those available in the literature.…”

Section: Analytical Proceduresmentioning

confidence: 99%

“…Both citron and cinnamon and their derivatives are used in carbonated drinks and alcoholic beverages as raw materials and/or flavoring agents. Their isolated EOs were previously tested for potential antimicrobial activity [9][10][11][12][13][14] and validated in food systems [8,15]. However, their application as biopreservatives in wines is lacking.…”

Section: Introductionmentioning

confidence: 99%

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Citrus medica and Cinnamomum zeylanicum Essential Oils as Potential Biopreservatives against Spoilage in Low Alcohol Wine Products

Mitropoulou

Nikolaou

Santarmaki

et al. 2020

Foods

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Low alcohol wine is a new entry in the global wine market, due to the increase in consumers’ concern for health, economic and modern lifestyle issues. As low alcohol products are prone to spoilage, the adoption of natural-derived products with antimicrobial activity as biopreservatives seems to be an intriguing alternative. Thus, the aim of the present study was to investigate the possible antimicrobial properties of Citrus medica and Cinnamomum zeylanicum essential oils (EOs) and assess their commercial prospective in the wine industry. The main constituents identified by GC/MS analysis were limonene (38.46%) and linalool (35.44%) in C. medica EO, whereas trans-cinnamic-aldehyde (63.58%) was the dominant compound in C. zeylanicum EO. The minimum inhibitory (MIC), non-inhibitory (NIC) and minimum lethal concentration (MLC) values against common wine spoilage microbes were initially determined. Subsequently, their efficiency was further validated in low alcohol (~6% vol) wines, either separately or in combination at 0.010% (v/v), as well as in wines deliberately inoculated with Gluconobacter cerinus, Oenococcus oeni, Pediococcus pentosaceus, Dekkera bruxellensis, Candida zemplinina, Hanseniaspora uvarum, Pichia guilliermondii or Zygosaccharomyces bailii. EO addition led to considerable spoilage and microbial growth delay during storage at room or refrigerated temperature, suggesting their potential use as wine biopreservatives.

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Section: Analytical Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Citrus medica and Cinnamomum zeylanicum Essential Oils as Potential Biopreservatives against Spoilage in Low Alcohol Wine Products

Mitropoulou

Nikolaou

Santarmaki

et al. 2020

Foods

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“…Citrus EOs are broadly used as natural food additives in several food and beverage products [ 7 ] because they have been classified as generally recognized as safe (GRAS) [ 8 ]. Furthermore, Citrus EOs are used as natural preservatives due to their broad spectrum of biological activities including antimicrobial and antioxidant effects [ 9 ]. The presence of terpenes, flavonoids, carotenes, and coumarins is thought to be responsible for the strong anti-oxidative and antimicrobial activities [ 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Biological Activities and Safety of Citrus spp. Essential Oils

Dosoky

Setzer

2018

IJMS

235

162

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Citrus fruits have been a commercially important crop for thousands of years. In addition, Citrus essential oils are valuable in the perfume, food, and beverage industries, and have also enjoyed use as aromatherapy and medicinal agents. This review summarizes the important biological activities and safety considerations of the essential oils of sweet orange (Citrus sinensis), bitter orange (Citrus aurantium), neroli (Citrus aurantium), orange petitgrain (Citrus aurantium), mandarin (Citrus reticulata), lemon (Citrus limon), lime (Citrus aurantifolia), grapefruit (Citrus × paradisi), bergamot (Citrus bergamia), Yuzu (Citrus junos), and kumquat (Citrus japonica).

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“…The used melanoma models are also indicated in the Table. Anthemis wiedemanniana -C32 [26] Artemisia anomala -BRO [27] Casearia lasiophylla -UACC-62 [30] Citrus bergamia Bergapten A375 [34] Citrus medica Limonene A375 [34,126] Coleus aromaticus Carvacrol A375 [127] Curcuma aromatica -B16 [36] Curcuma kwangsiensis -B16 [37] Curcuma zedoaria -B16-Bl6 [38] Eryngium amethystinum -A375 [40] Eryngium campestre -A375 [40] Eugenia cuspidifolia -SK-MEL-19 [42] Eugenia tapacumensis -SK-MEL-19 [42] Eugenia uniflora Curzerene SK-MEL-19 [43] Helichrysum microphyllum -A375 [45] Heracleum sphondylium Octyl butyrate A375 [46] Hypericum hircinum -B16-F1 [47] Laurus nobilis -C32 [48] Lippia gracilis -B16-F10 [50,128] Liriodendron tulipifera β-Elemene A375 [51] Melaleuca alternifolia Terpinen-4-ol A375, M14, B16-F10 [52,129,130] Melaleuca quinquenervia…”

Section: Inhibition Of Cell Proliferationmentioning

confidence: 99%

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

Martile

Garzoli

Ragno

et al. 2020

Cancers

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The last two decades have seen the development of effective therapies, which have saved the lives of a large number of melanoma patients. However, therapeutic options are still limited for patients without BRAF mutations or in relapse from current treatments, and severe side effects often occur during therapy. Thus, additional insights to improve treatment efficacy with the aim to decrease the likelihood of chemoresistance, as well as reducing side effects of current therapies, are required. Natural products offer great opportunities for the discovery of antineoplastic drugs, and still represent a useful source of novel molecules. Among them, essential oils, representing the volatile fraction of aromatic plants, are always being actively investigated by several research groups and show promising biological activities for their use as complementary or alternative medicine for several diseases, including cancer. In this review, we focused on studies reporting the mechanism through which essential oils exert antitumor action in preclinical wild type or mutant BRAF melanoma models. We also discussed the latest use of essential oils in improving cancer patients’ quality of life. As evidenced by the many studies listed in this review, through their effect on apoptosis and tumor progression-associated properties, essential oils can therefore be considered as potential natural pharmaceutical resources for cancer management.

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Citrus medica essential oil exhibits significant antimicrobial and antiproliferative activity

Cited by 76 publications

References 30 publications

Citrus medica and Cinnamomum zeylanicum Essential Oils as Potential Biopreservatives against Spoilage in Low Alcohol Wine Products

Citrus medica and Cinnamomum zeylanicum Essential Oils as Potential Biopreservatives against Spoilage in Low Alcohol Wine Products

Biological Activities and Safety of Citrus spp. Essential Oils

Essential Oils and Their Main Chemical Components: The Past 20 Years of Preclinical Studies in Melanoma

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