Citrus juice modulates bone strength in male senescent rat model of osteoporosis

Deyhim, Farzad; Garica, Kristy; Lopez, Erica; J, González; Ino, Sumiyo; Garcia, Michelle; Patil, Bhimanagouda S.

doi:10.1016/j.nut.2005.12.002

Cited by 80 publications

(55 citation statements)

References 24 publications

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“…Citrus juice, the main dietary source of flavanones, modulates bone strength and quality, whereas the flavanone hesperedin inhibited bone loss by affecting osteoblast differentiation through bone morphogenetic protein and mitogen-activated protein kinase (MAPK) signaling. (7,(10)(11)(12)33,34) In another study, the flavanone glycoside, naringin, protected against ovariectomy-induced bone loss, potentially mediated through ligand-independent activation of estrogen receptors in osteoblastic cells. (10) Mechanistic support also exists for a beneficial effect of higher flavonol intake on BMD; quercetin and kampferol have been found to inhibit bone loss in ovariectomized mice (8) via a range of potential mechanisms including effects on osteoclast differentiation involving NF-kB and AP-1 induction by RANKL, (13,15) stimulating alkaline phosphatase activity, promoting osteoblast activity, and upregulating bone sialoprotein gene promoter.…”

Section: Discussionmentioning

confidence: 96%

Habitual flavonoid intakes are positively associated with bone mineral density in women

Welch

Macgregor

Jennings

et al. 2012

Journal of Bone and Mineral Research

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Dietary flavonoids exert bone-protective effects in animal models, but there is limited information on the effect of different flavonoid subclasses on bone health in humans. The aim of this observational study was to examine the association between habitual intake of flavonoid subclasses with bone mineral density (BMD) in a cohort of female twins. A total of 3160 women from the TwinsUK adult twin registry participated in the study. Habitual intakes of flavonoids and subclasses (flavanones, anthocyanins, flavan-3-ols, polymers, flavonols, and flavones) were calculated from semiquantitative food frequency questionnaires using an updated and extended U.S. Department of Agriculture (USDA) database. Bone density was measured using dual-energy X-ray absorptiometry. In multivariate analyses, total flavonoid intake was positively associated with higher BMD at the spine but not at the hip. For the subclasses, the magnitude of effect was greatest for anthocyanins, with a 0.034 g/cm 2 (3.4%) and 0.029 g/cm 2 (3.1%) higher BMD at the spine and hip, respectively, for women in the highest intake quintile compared to those in the lowest. Participants in the top quintile of flavone intake had a higher BMD at both sites; 0.021 g/cm 2 (spine) and 0.026 g/cm 2 (hip). At the spine, a greater intake of flavonols and polymers was associated with a higher BMD (0.021 and 0.024 g/cm 2 , respectively), whereas a higher flavanone intake was positively associated with hip BMD (0.008 g/cm 2 ). In conclusion, total flavonoid intake was positively associated with BMD, with effects observed for anthocyanins and flavones at both the hip and spine, supporting a role for flavonoids present in plant-based foods on bone health. ß

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Section: Discussionmentioning

confidence: 96%

Habitual flavonoid intakes are positively associated with bone mineral density in women

Welch

Macgregor

Jennings

et al. 2012

Journal of Bone and Mineral Research

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“…This work is supported by animal studies in which nonpharmacologic doses of citrus juice have been shown to exert a positive effect on decreasing bone resorption in male rats. (50) A study by Chiba and colleagues (14) found that hesperidin prevented bone loss in ovariectomized mice, suggesting that this flavanone may be useful in preventing disease arising from estrogen deficiency, although the molecular mechanisms behind this observation are still unclear. Hesperidin has a high antioxidant capacity, and it has been suggested that bone resorption is decreased by inhibition of osteoclastic superoxide availability.…”

Section: Discussionmentioning

confidence: 99%

Associations between dietary flavonoid intakes and bone health in a scottish population

Hardcastle

Aucott

Reid

et al. 2010

Journal of Bone and Mineral Research

102

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Flavonoids are bioactive polyphenols found particularly in fruit and vegetables, but little is known about their role in bone health in humans. The aim of this observational study was to investigate whether dietary flavonoid intake was associated with bone mineral density (BMD) and bone resorption in a large group of perimenopausal Scottish women. Over 3000 women completed a food frequency questionnaire as part of an osteoporosis screening study. The diets were analyzed for flavonoid intake using a food composition database. BMD was measured at the femoral neck (FN) and lumbar spine (LS) by dual-energy X-ray absorptiometry (DXA). Free pyridinoline (PYD) and deoxypyridinoline (DPD) were measured by high-performance liquid chromatography (HPLC) in second early morning fasted urine samples. The mean flavonoid intake of the diet was 307 AE199 mg/d. The catechin family contributed the most to flavonoid intakes (55%), and the flavones the least (<1%). Associations were found between energy-adjusted total flavonoid intakes and BMD at the FN and LS (FN r ¼ 0.054, LS r ¼ 0.036, p .05). Annual percent change in BMD was associated with intakes of procyanidins and catechins ( p .05), and flavanones were negatively associated with bone-resorption markers (PYD r ¼ À0.049, DPD r ¼ -0.057, p .001). These associations were still seen after adjusting for confounders. It is concluded that dietary flavonoid intakes are associated with BMD, supporting the evidence from animal and cellular studies. ß

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“…Lemon is considered to be an excellent natural diuretic and using lemons is recommended to those who have high uric acid problems, urinary tract infections and other related ailments. Health benefits of lemon juice also include relieving the symptoms of respiratory diseases, such as asthma, etc (Attaway 1994;Deyhim et al 2006;Duyn and Pivonka 2000).…”

Section: Introductionmentioning

confidence: 99%

Non-enzymatic browning in citrus juice: chemical markers, their detection and ways to improve product quality

Bharate¹,

Bharate

2012

J Food Sci Technol

117

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Citrus juices are widely consumed due to their nutritional benefits and variety of pharmacological properties. Non-enzymatic browning (NEB) is one of the most important chemical reactions responsible for quality and color changes during the heating or prolonged storage of citrus products. The present review covers various aspects of NEB in citrus juice viz. chemistry of NEB, identifiable markers of NEB, analytical methods to identify NEB markers and ways to improve the quality of citrus juice. 2,5-Dimethyl-4-hydroxy-3(2H)-furanone (DMHF) is one of the promising marker formed during browning process with number of analytical methods reported for its analysis; therefore it can be used as an indicator for NEB process. Amongst analytical methods reported, RP-HPLC is more sensitive and accurate method, which can be used as analytical tool. NEB can be prevented by removal of amino acids/ proteins (via ion exchange treatment) or by targeting NEB reactions (e.g. blockage of furfural/ HMF by sulphiting agent).

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Citrus juice modulates bone strength in male senescent rat model of osteoporosis

Cited by 80 publications

References 24 publications

Habitual flavonoid intakes are positively associated with bone mineral density in women

Habitual flavonoid intakes are positively associated with bone mineral density in women

Associations between dietary flavonoid intakes and bone health in a scottish population

Non-enzymatic browning in citrus juice: chemical markers, their detection and ways to improve product quality

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