Citrus decline, a common problem in sweet orange (Citrus sinensis Osbeck) growing areas of Marathwada region of Maharashtra, India, was investigated from the standpoint of soil fertility and plant nutritional constraints during 1999-2002. To diagnose the nutritional constraints, optimum soil-available nutrients, and leaf nutrient concentration in relation to fruit yield were determined through multivariate quadratic regression analysis. Soil factors (viz., exchangeable Ca 2þ and Na þ ) and suboptimum levels of nitrogen (N), phosphorus (P), potassium (K), calcium (Ca), iron (Fe), ORDER REPRINTS manganese (Mn), zinc (Zn), and boron (B) both in soil and leaf proved to be important contributory factors toward citrus decline. The soil and plant factors that were important are (in the order of their increasing importance): leaf Mn < soil pH < leaf Zn < leaf Fe < available P < soil CaCO 3 < available Mn < available Cu < available K < leaf P < soil EC < available Zn < leaf Cu < leaf K < available Fe < leaf K < available N. These observations suggest a definite role of different soil fertility and plant nutritional factors causing citrus decline.