Citrullus colocynthis (L.) Schrad (bitter apple fruit): A review of its phytochemistry, pharmacology, traditional uses and nutritional potential

Hussain, Abdullah Ijaz; Rathore, Hassaan Anwer; Sattar, Munavvar Zubaid Abdul; Chatha, Shahzad Ali Shahid; Sarker, Satyajit D.; Gilani, Anwarul Hassan

doi:10.1016/j.jep.2014.06.011

Cited by 170 publications

(128 citation statements)

References 68 publications

(113 reference statements)

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Colocynth is a rich source of functionally important bioactive compounds and therapeutics such as polyphenols, glycosides, triterpenes and cucurbitacins and its fruit has been widely used for the treatment of many diseases including diabetes, rheumatism, paronychia, ulcer and cancer (Hussain et al, 2014). However, the biotechnology of C. colocynthis is still underexplored.…”

Section: Future Perspectivesmentioning

confidence: 99%

“…C. colocynthis has only one accepted name but six synonyms (The Plant List, 2017). In India and Pakistan, it is known as tumba (Mahajan and Kumawat, 2013;Hussain et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Fruits hold bioactive chemical constituents such as glycosides, flavonoids, alkaloids and terpenoids while "curcurbitacins A, B, C, D, E, I, J, K, and L and Colocynthosides A, and B" have also been isolated (Hussain et al, 2014). Several accessions have shown resistance to several viruses and diseases (Dabauza et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Citrullus colocynthis (L.) Schrad. (colocynth): Biotechnological perspectives

Silva¹,

Hussain

2017

Emir. J. Food Agric

View full text Add to dashboard Cite

Section: Future Perspectivesmentioning

confidence: 99%

“…C. colocynthis has only one accepted name but six synonyms (The Plant List, 2017). In India and Pakistan, it is known as tumba (Mahajan and Kumawat, 2013;Hussain et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Citrullus colocynthis (L.) Schrad. (colocynth): Biotechnological perspectives

Silva¹,

Hussain

2017

Emir. J. Food Agric

View full text Add to dashboard Cite

“…The blood glucose-lowering efficacy of a few members of Cucurbitaceae family has been assessed by many researchers worldwide. [8][9][10] Pointed gourd (Trichosanthes dioica Roxb (L.)) is known by the name of parwal, palwal, parmal, patol, and potala in different parts of India and Bangladesh and is one of the important vegetables. [11] The fruits and leaves are the edible parts of the plant which are cooked in various ways, either alone or in combination with other vegetables or meats.…”

Section: Banu World Journal Of Pharmaceutical Researchmentioning

confidence: 99%

Cucurbitacin Augments Insulin Sensitivity and Glucose Uptake Through Translocation and Activation of Glut4 in Pi3k/Akt Signaling Pathway

Banu¹

2017

WJPR

View full text Add to dashboard Cite

Vegetables that are generally consumed in India as one of the main components of the diet have been proven for their antidiabetic potential. Cucurbitacin is an important member of the Cucurbitaceae family and exhibit potential effects in various metabolic disorders and cancer. The aim of the present study is to investigate the effect and the mechanism of cucurbitacin on glucose uptake in an insulin target skeletal muscle and activation of PI3k/Akt signaling pathways in STZ induced diabetic animal model. STZ induced diabetic rats showed significantly elevated levels of plasma glucose, TBARS, and lipid hydroperoxides, and decreased levels of plasma insulin and enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non -enzymatic antioxidants (vitamin C, E and GSH), and impairment in insulin signaling proteins including IR, IRS-1/2, Akt, PI3K, GLUT4, and PPAR-γ proteins. The administration of cucurbitacin (5 mg/kg b.w/p.o) showed near-normalized levels of plasma glucose, lipid peroxidation products, enzymatic and non-enzymatic antioxidants and improved insulin signaling proteins. Based on the present findings, cucurbitacin improves glucose uptake by enhancing GLUT4 protein activities in skeletal muscle through PI3K/Akt and antioxidant defense in plasma and it also maintains blood glucose homeostasis.

show abstract

“…The fruits of the colocynth have been prescribed for the treatment of gastrointestinal diseases, respiratory infections, diabetes and cancer (reviewed in [53]). Fresh Stellaria media L. (chickweed) juice has been administered for the treatment of viral diseases and dermatitis [132].…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

et al. 2016

View full text Add to dashboard Cite

Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants from which RIPs have been isolated. The overview starts from the antique age of the Mediterranean area with ancient Egypt, followed by the Greek and Roman classic period. Then, the ancient oriental civilizations of China and India are evaluated. More recently, Unani medicine and European folk medicine are examined. Finally, the African and American folk medicines are taken into consideration. In conclusion, a list of RIP-expressing plants, which have been used in folk medicine, is provided with the geographical distribution and the prescriptions that are recommended by traditional healers. Some final considerations are provided on the present utilization of such herbal treatments, both in developing and developed countries, often in the absence of scientific validation. The most promising prospect for the medicinal use of RIP-expressing plants is the conjugation of purified RIPs to antibodies that recognise tumour antigens for cancer therapy.

show abstract

Citrullus colocynthis (L.) Schrad (bitter apple fruit): A review of its phytochemistry, pharmacology, traditional uses and nutritional potential

Cited by 170 publications

References 68 publications

Citrullus colocynthis (L.) Schrad. (colocynth): Biotechnological perspectives

Citrullus colocynthis (L.) Schrad. (colocynth): Biotechnological perspectives

Cucurbitacin Augments Insulin Sensitivity and Glucose Uptake Through Translocation and Activation of Glut4 in Pi3k/Akt Signaling Pathway

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

Contact Info

Product

Resources

About