Citrullus colocynthis as a medicinal or poisonous plant: A revised fact

Shafaei, Hajar; Esmaeili, Abolghasem; Rad, Jafar Soleimani; Delazar, Abbas; Behjati, Mohaddesemh

doi:10.5897/jmpr11.264

Cited by 20 publications

(11 citation statements)

References 23 publications

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“…In AESI treated female rats, a reduction observed in seric level of glucose compared with the control group was in line with the work reported by Benmehdi et al [26]. According to Shafaei et al [27], the observed hypoglycemic effects of the pulp extract of Citrullus colocynthis may be due to wounded intestine and injured renal proximal tubules and their subsequent reduced ability to regulate glucose transportation. In addition, impaired hepatic function and glucose metabolism may be a contributing mechanism for induced hypoglycemia [28].…”

Section: Hematologicalsupporting

confidence: 88%

Evaluation of Acute and Sub-acute Toxicity of the Aqueous Extract from the Fruit of Solanum indicum Linn. (Solanaceae) in Rats

Epoh

Dongmo

Tadjoua

et al. 2019

EJMP

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Aim: The fruit of Solanum indicum Linn have been reported traditionally to have anti-hypertensive and diuretic properties. This study was undertaken to evaluate the toxicological potential of S. indicum fruits aqueous extract through the acute and sub-acute toxicity tests in rats. Methodology: For acute toxicity evaluation, a single oral dose of 5000 mg/kg of the plant extract was administrated in 60 days old female albino Wistar rats. Then, the animals were observed for 14 days. Sub-acute toxicity studies were conducted with 50 adult rats of both gender that orally received during 28 days, increasing doses of the plant extract. Their body weight and food intake were weekly collected. At the end of the experiment, biochemical and hematological parameters as well as histological analysis of organs (liver, kidneys and spleen) were undertaken. Results: Single oral administration of 5000 mg/kg dose of the fruit plant aqueous extract produced no mortality or signs of toxicity. During sub-acute test, no variations in body weight and food intake of both animals gender were observed. An important decrease in male’s rat liver weight were obtained at the dose 25 mg/kg; serum urea, total cholesterol, TAG, ALP and AST levels were signiﬁcantly lowered in male especially at the dose 50 mg/kg, but this decrease was noticed only in serum urea, ALP and ALT in female rats. Furthermore, a significant decrease in platelets number, serum PCT, MPV and PDW levels were recorded in all treated male rats except those receiving the highest extract dose. No structural changes in treated animal organs section histology were observed when compared to controls. Conclusion: The fruits aqueous extracts of S. indicum is safe when administered acutely and for 28 days in rats. However, alterations on their hematological and biochemical parameters were not closely related with the dose, implying caution on its use.

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Section: Hematologicalsupporting

confidence: 88%

Evaluation of Acute and Sub-acute Toxicity of the Aqueous Extract from the Fruit of Solanum indicum Linn. (Solanaceae) in Rats

Epoh

Dongmo

Tadjoua

et al. 2019

EJMP

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“…Moreover, serious poisoning cases inducing sometimes death were reported after oral administration of R. raetam and C. colocynthis . In this regard, previous pharmacological studies confirmed the lethal effect of the pulp extract of C. colocynthis received by rabbits [ 42 ] and also its toxicity on liver cells which may engender hepatocyte necrosis and liver fibrosis [ 43 ]. Likewise, the findings of Algandaby [ 44 ] revealed that the repeated administration of excessive doses of methanolic extract of R. raetam in rats could exhibit hepatotoxic, nephrotoxic, and mutagenic effects.…”

Section: Resultsmentioning

confidence: 82%

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Karous

Jilani

Ghrabi-Gammar

2021

Plants

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Thanks to its geographic location between two bioclimatic belts (arid and Saharan) and the ancestral nomadic roots of its inhabitants, the sector of Ouled Dabbeb (Southern Tunisia) represents a rich source of plant biodiversity and wide ranging of ethnobotanical knowledge. This work aims to (1) explore and compile the unique diversity of floristic and ethnobotanical information on different folk use of plants in this sector and (2) provide a novel insight into the degree of knowledge transmission between the current population and their semi-nomadic forefathers. Ethnobotanical interviews and vegetation inventories were undertaken during 2014–2019. Thirty informants aged from 27 to 84 were interviewed. The ethnobotanical study revealed that the local community of Ouled Dabbeb perceived the use of 70 plant species belonging to 59 genera from 31 families for therapeutic (83%), food (49%), domestic (15%), ethnoveterinary (12%), cosmetic (5%), and ritual purposes (3%). Moreover, they were knowledgeable about the toxicity of eight taxa. Nearly 73% of reported ethnospecies were freely gathered from the wild. The most commonly used plant parts were leaves (41%) followed by flowers and inflorescence (16%). We reported the use and collection of non-renewable parts (underground storage organs and roots) for 20 ethnospecies. Interestingly, a comparison with the available literature in Tunisia and neighboring countries reveals 13 new useful plants as well as 17 plants with new uses and demonstrates an important reservoir of traditional ethnobotanical heritage that is still sustained by respondents stemming from the semi-nomadic lifestyle of their ancestors (74% of cited taxa). These data could set a basis for further phytochemical and pharmacological research and conservative approach of the most relevant plant species including endemic overused and endangered taxa.

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“…The membranolytic activity of saponin—an ingredient of the pulp extract—is believed to be the main pathophysiological mechanism for intestinal damage [6]. …”

Section: Discussionmentioning

confidence: 99%

“…Different parts of the plant including seeds, fruit, root, stem, and leaves, used as either aqueous or oil extracts, dried or fresh, are believed to have antidiabetic [1–6], antihyperlipidemic [7, 8], laxative [1, 3, 9], anti-inflammatory [9], analgesic [9], vermifuge [5], hair-growth-promoting [10], antibacterial [11], antifungal [11], and antioxidant properties [12]. …”

Section: Introductionmentioning

confidence: 99%

Citrullus colocynthisas the Cause of Acute Rectorrhagia

Javadzadeh

Davoudi

et al. 2013

Case Reports in Emergency Medicine

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Introduction. Citrullus colocynthis Schrad. is a commonly used medicinal plant especially as a hypoglycemic agent. Case Presentation. Four patients with colocynth intoxication are presented. The main clinical feature was acute rectorrhagia preceeded by mucosal diarrhea with tenesmus, which gradually progressed to bloody diarrhea and overt rectorrhagia within 3 to 4 hours. The only colonoscopic observation was mucosal erosion which was completely resolved in follow-up colonoscopy after 14 days. Conclusion. The membranolytic activity of some C. colocynthis ingredients is responsible for the intestinal damage. Patients and herbalists should be acquainted with the proper use and side effects of the herb. Clinicians should also be aware of C. colocynthis as a probable cause of lower GI bleeding in patients with no other suggestive history, especially diabetics.

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Citrullus colocynthis as a medicinal or poisonous plant: A revised fact

Cited by 20 publications

References 23 publications

Evaluation of Acute and Sub-acute Toxicity of the Aqueous Extract from the Fruit of Solanum indicum Linn. (Solanaceae) in Rats

Evaluation of Acute and Sub-acute Toxicity of the Aqueous Extract from the Fruit of Solanum indicum Linn. (Solanaceae) in Rats

Ethnobotanical Study on Plant Used by Semi-Nomad Descendants’ Community in Ouled Dabbeb—Southern Tunisia

Citrullus colocynthisas the Cause of Acute Rectorrhagia

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