Citrulline malate transdermal delivery through integrating into polyvinyl alcohol (PVA) nanofibers

López-Ramírez, Elizabeth; González, Christian Chapa; Martínez-Pérez, Carlos A.; Escobedo‐González, René; Nicolás–Vázquez, María Inés; Medellín‐Rodríguez, F. J.; García-Casillas, Perla E.

doi:10.1016/j.jddst.2021.102630

Cited by 4 publications

(4 citation statements)

References 51 publications

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“…It is important to mention that these theoretical methods alone or complemented with the obtained experimental results can offer advantages to the design, in addition to predicting and explaining the structural properties in miscellaneous nanoand biomaterials [38][39][40]. Additionally, the achieved theoretical results provide excellent support to appropriately assign and correlate both bands and signals from several analytical techniques: UV-VIS, Raman, infrared and NMR [41][42][43][44]. In this sense, density functional theory (DFT) calculations have been useful and competent in predicting materials' properties [39,43,45,46].…”

Section: Introductionmentioning

confidence: 83%

“…Regarding the quantum chemical literature [55], the B3LYP functional yields a good description of harmonic vibrational wavenumbers. However, the quantum chemical results differ from the measured ones and, consequently, these calculations were scaled; in this sense, the thermal contributions to the vibrational energy were scaled by 0.963 [43,44].…”

Section: Vibrational Analysismentioning

confidence: 99%

“…Thermochemical values were estimated from frequency calculations, including a thermochemical analysis of the system considering 298.15 K, 1 atm of pressure and the principal isotope for each element, all at the same theory level. Zero-point correction to the electronic energy (ZPE) of the molecule was used to calculate the values of enthalpy and Gibbs free energy (Equations ( 2) and ( 3)) [31,33,44,110].…”

Section: Thermochemical Parametersmentioning

confidence: 99%

“…β-CDNH2/PCL and EGF-β-CDNH2/PCL showed the best cell viability and cicatricial effect, in comparison to PCL and β-CD/PCL. Considering both the importance of these materials and the requirement of appropriated knowledge of the interactions with the polymeric matrix in biological uses [44,49], Considering both the importance of these materials and the requirement of appropriated knowledge of the interactions with the polymeric matrix in biological uses [44,49], our research group deemed it convenient to report the novel and interesting results obtained via a theoretical study of the target materials of this work. Therefore, a quantum chemistry approach was used to calculate the minimum energy of the designed structures, also determining their geometrical parameters and spectrophotometric data using IR and Raman techniques.…”

Section: Introductionmentioning

confidence: 99%

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In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration

Escobedo‐González

Moyers-Montoya

Perez

et al. 2023

IJMS

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Three novel biomaterials obtained via inclusion complexes of β–cyclodextrin, 6-deoxi-6-amino-β–cyclodextrin and epithelial growth factor grafted to 6-deoxi-6-amino-β–cyclodextrin with polycaprolactone. Furthermore, some physicochemical, toxicological and absorption properties were predicted using bioinformatics tools. The electronic, geometrical and spectroscopical calculated properties agree with the properties obtained via experimental methods, explaining the behaviors observed in each case. The interaction energy was obtained, and its values were −60.6, −20.9 and −17.1 kcal/mol for β–cyclodextrin/polycaprolactone followed by the 6-amino-β–cyclodextrin-polycaprolactone complex and finally the complex of epithelial growth factor anchored to 6-deoxy-6-amino–β–cyclodextrin/polycaprolactone. Additionally, the dipolar moments were calculated, achieving values of 3.2688, 5.9249 and 5.0998 Debye, respectively, and in addition the experimental wettability behavior of the studied materials has also been explained. It is important to note that the toxicological predictions suggested no mutagenic, tumorigenic or reproductive effects; moreover, an anti-inflammatory effect has been shown. Finally, the improvement in the cicatricial effect of the novel materials has been conveniently explained by comparing the poly-caprolactone data obtained in the experimental assessments.

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Section: Introductionmentioning

confidence: 83%

Section: Vibrational Analysismentioning

confidence: 99%

Section: Thermochemical Parametersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration

Escobedo‐González

Moyers-Montoya

Perez

et al. 2023

IJMS

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Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

Kumar

Verma²,

Joshi

et al. 2021

Futur J Pharm Sci

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Background Transdermal delivery of drugs is a quite challenging task for pharmaceutical scientists. The transdermal route is preferred over the oral route due to various advantages like avoidance of the first-pass effect, non-invasiveness, and high patient compliance. Therefore, it is necessary to develop an effective carrier system that enables the effective passage of the drug through the dermal barrier. Main body of abstract Various novel drug delivery systems are used to enhance the permeation of a variety of drugs through the skin barrier. Researchers around the globe have explored nanofibers for the transdermal delivery of various therapeutic agents. Nanofibers are designed to have a high concentration of therapeutic agents in them promoting their flux through various skin layers. Polymeric nanofibers can be explored for the loading of both hydrophilic and lipophilic drugs. Biopolymer-based nanofibers have been also explored for transdermal delivery. They are capable of controlling the release of therapeutic agents for a prolonged time. Short conclusion The literature presented in this review paper provides significant proof that nanofibers will have an intense impact on the transdermal delivery of different bioactive molecules in the future. Graphic abstract

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Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration

Barros Araújo,

da Silva Soares,

da Silva Lima

et al. 2023

CPD

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Background: Nanofibers have shown promising clinical results in the process of tissue regeneration since they provide a similar structure to the extracellular matrix of different tissues, high surface-to-volume ratio and porosity, flexibility, and gas permeation, offering topographical features that stimulate cell adhesion and proliferation. Electrospinning is one of the most used techniques for manufacturing nanomaterials due to its simplicity and low cost. Objective: In this review, we highlight the use of nanofibers produced with polyvinyl alcohol and polymeric associations (PVA/blends) as a matrix for release capable of modifying the pharmacokinetic profile of different active ingredients in the regeneration of connective, epithelial, muscular, and nervous tissues. Methods: Articles were selected by three independent reviewers by analyzing the databases, such as Web of Science, PubMed, Science Direct, and Google Scholar (last 10 years). Descriptors used were “nanofibers”, “poly (vinyl alcohol)”, “muscle tissue”, “connective tissue”, “epithelial tissue”, and “neural tissue engineering”. The guiding question was: How do different compositions of polyvinyl alcohol polymeric nanofibers modify the pharmacokinetics of active ingredients in different tissue regeneration processes? Results: The results demonstrated the versatility of the production of PVA nanofibers by solution blow technique with different actives (lipo/hydrophilic) and with pore sizes varying between 60 and 450 nm depending on the polymers used in the mixture, which influences the drug release that can be controlled for hours or days. The tissue regeneration showed better cellular organization and greater cell proliferation compared to the treatment with the control group, regardless of the tissue analyzed. Conclusion: We highlight that, among all blends, the combinations PVA/PCL and PVA/CS showed good compatibility and slow degradation, indicating their use in prolonged times of biodegradation, thus benefiting tissue regeneration in bone and cartilage connective tissues, acting as a physical barrier that results in guided regeneration, and preventing the invasion of cells from other tissues with increased proliferation rate.

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Citrulline malate transdermal delivery through integrating into polyvinyl alcohol (PVA) nanofibers

Cited by 4 publications

References 51 publications

In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration

In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration

Nanofiber as a novel vehicle for transdermal delivery of therapeutic agents: challenges and opportunities

Polyvinyl Alcohol Nanofibers Blends as Drug Delivery System in Tissue Regeneration

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