Citronellol Disrupts Membrane Integrity by Inducing Free Radical Generation

Kaur, Shalinder; Rana, Shivani; Singh, Harminder Pal; Batish, Daizy R.; Kohli, R. K.

doi:10.1515/znc-2011-5-609

Cited by 23 publications

(7 citation statements)

References 23 publications

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“…The damaged was more severe in the root and a higher lipoxygenase activity was observed in parallel with accumulation of MDA [43]. The up-regulation of LOX activity has been observed for citronellol as well and the authors suggest that its hydroperoxide derivatives may destroy the membrane [44].…”

Section: Reactive Oxygen and Nitrogen Species Inductionmentioning

confidence: 85%

Phytotoxicity of Essential Oils: Opportunities and Constraints for the Development of Biopesticides. A Review

Werrie

Durenne

Delaplace

et al. 2020

Foods

117

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The extensive use of chemical pesticides leads to risks for both the environment and human health due to the toxicity and poor biodegradability that they may present. Farmers therefore need alternative agricultural practices including the use of natural molecules to achieve more sustainable production methods to meet consumer and societal expectations. Numerous studies have reported the potential of essential oils as biopesticides for integrated weed or pest management. However, their phytotoxic properties have long been a major drawback for their potential applicability (apart from herbicidal application). Therefore, deciphering the mode of action of essential oils exogenously applied in regards to their potential phytotoxicity will help in the development of biopesticides for sustainable agriculture. Nowadays, plant physiologists are attempting to understand the mechanisms underlying their phytotoxicity at both cellular and molecular levels using transcriptomic and metabolomic tools. This review systematically discusses the functional and cellular impacts of essential oils applied in the agronomic context. Putative molecular targets and resulting physiological disturbances are described. New opportunities regarding the development of biopesticides are discussed including biostimulation and defense elicitation or priming properties of essential oils.

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Section: Reactive Oxygen and Nitrogen Species Inductionmentioning

confidence: 85%

Phytotoxicity of Essential Oils: Opportunities and Constraints for the Development of Biopesticides. A Review

Werrie

Durenne

Delaplace

et al. 2020

Foods

117

View full text Add to dashboard Cite

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“…The three molecules have already been studied for their herbicide potential. CitO and CitA were shown to inhibit germination, root, and/or shoot growth of different plants [24,28,29,30]. On the other hand, CIN was only reported to be phytotoxic on Chinese amaranth [38].…”

Section: Discussionmentioning

confidence: 99%

“…As herbicide, CitO enhances solute leakage and induces ROS generation on root and shoot growth of Triticum aestivum . ROS production could result in lipid peroxidation and membrane damage [24].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components

Lins

Maso

Foncoux

et al. 2019

IJMS

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Since the 50’s, the massive and “environmental naïve” use of synthetic chemistry has revolutionized the farming community facing the dramatic growth of demography. However, nowadays, the controversy grows regarding the long-term harmful effects of these products on human health and the environment. In this context, the use of essential oils (EOs) could be an alternative to chemical products and a better understanding of their mode of biological action for new and optimal applications is of importance. Indeed, if the biocidal effects of some EOs or their components have been at least partly elucidated at the molecular level, very little is currently known regarding their mechanism of action as herbicides at the molecular level. Here, we showed that cinnamon and Java citronella essential oils and some of their main components, i.e.,, cinnamaldehyde (CIN), citronellal (CitA), and citronellol (CitO) could act as efficient herbicides when spread on A. thaliana leaves. The individual EO molecules are small amphiphiles, allowing for them to cross the mesh of cell wall and directly interact with the plant plasma membrane (PPM), which is one of the potential cellular targets of EOs. Hence, we investigated and characterized their interaction with biomimetic PPM while using an integrative biophysical approach. If CitO and CitA, maintaining a similar chemical structure, are able to interact with the model membranes without permeabilizing effect, CIN belonging to the phenylpropanoid family, is not. We suggested that different mechanisms of action for the two types of molecules can occur: while the monoterpenes could disturb the lipid organization and/or domain formation, the phenylpropanoid CIN could interact with membrane receptors.

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“…Citronellol was reported to inhibit root and shoot growth of Triticum aestivum by ROS-mediated membrane disruption. ROS production could result in lipid peroxidation, membrane damage, and solute leakage ( 240 ). As a consequence of the disruption of the membrane integrity, Citronellal-treated weed leaves showed cuticular wax interruption, stomata clogging, epidermal cell shrinkage, and rapid electrolyte leakage ( 241 ).…”

Section: Properties Of Eos As Broad-spectrum Anti-microbial Agentsmentioning

confidence: 99%

Biocontrol Potential of Essential Oils in Organic Horticulture Systems: From Farm to Fork

et al. 2022

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In recent decades, increasing attention has been paid to food safety and organic horticulture. Thus, people are looking for natural products to manage plant diseases, pests, and weeds. Essential oils (EOs) or EO-based products are potentially promising candidates for biocontrol agents due to their safe, bioactive, biodegradable, ecologically, and economically viable properties. Born of necessity or commercial interest to satisfy market demand for natural products, this emerging technology is highly anticipated, but its application has been limited without the benefit of a thorough analysis of the scientific evidence on efficacy, scope, and mechanism of action. This review covers the uses of EOs as broad-spectrum biocontrol agents in both preharvest and postharvest systems. The known functions of EOs in suppressing fungi, bacteria, viruses, pests, and weeds are briefly summarized. Related results and possible modes of action from recent research are listed. The weaknesses of applying EOs are also discussed, such as high volatility and low stability, low water solubility, strong influence on organoleptic properties, and phytotoxic effects. Therefore, EO formulations and methods of incorporation to enhance the strengths and compensate for the shortages are outlined. This review also concludes with research directions needed to better understand and fully evaluate EOs and provides an outlook on the prospects for future applications of EOs in organic horticulture production.

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Citronellol Disrupts Membrane Integrity by Inducing Free Radical Generation

Cited by 23 publications

References 23 publications

Phytotoxicity of Essential Oils: Opportunities and Constraints for the Development of Biopesticides. A Review

Phytotoxicity of Essential Oils: Opportunities and Constraints for the Development of Biopesticides. A Review

Insights into the Relationships Between Herbicide Activities, Molecular Structure and Membrane Interaction of Cinnamon and Citronella Essential Oils Components

Biocontrol Potential of Essential Oils in Organic Horticulture Systems: From Farm to Fork

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