Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells

Jayaganesh, Rajendran; Pugalendhi, Pachaiappan; Rajakumar, Thangarasu

doi:10.1080/01635581.2020.1800766

Cited by 9 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Citronellol has been described with antitumor activity against lung [ 61 ] and breast cancers [ 62 ], inducing necroptosis and apoptosis, respectively. For lung cancer, IC50 was found to be 49.74 μ g/mL and necroptosis was confirmed by an upregulation of TNF- α pathway and downregulation of caspase-3 and -8 activities.…”

Section: Resultsmentioning

confidence: 99%

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Monoterpenes are a group of natural products that have been widely studied due to their therapeutic potential against various pathologies. These compounds are abundant in the chemical composition of essential oils. Cancer is a term that covers more than 100 different types of malignant diseases and is among the leading causes of death in the world. Therefore, the search for new pharmacotherapeutic options applicable to cancer is urgent. In this review, studies on the antitumor activity of monoterpenes found in essential oils were selected, and botanical, chemical, and pharmacological aspects were discussed. The most investigated monoterpenes were carvacrol and linalool with highly significant in vitro and in vivo tumor inhibition in several types of cancers. The action mechanisms of these natural products are also presented and are wildly varied being apoptosis the most prevalent followed by cell cycle impairment, ROS production, autophagy, necroptosis, and others. The studies reported here confirm the antitumor properties of monoterpenes and their anticancer potential against various types of tumors, as demonstrated in in vitro and in vivo studies using various types of cancer cells and tumors in animal models. The data described serve as a reference for the advancement in the mechanistic studies of these compounds and in the preparation of synthetic derivatives or analogues with a better antitumor profile.

show abstract

Section: Resultsmentioning

confidence: 99%

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Machado

Fonseca

Duarte

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…Moreover, Limonene arrested the cell cycle in the G2/M phase and wound healing and transwell assay using Matrigel has confirmed the limonene mediated suppression of cancer cell migration and invasion [141]. Another component of the EO of lemongrass, citronellol, is also found to exert cytotoxic effects on several cancer cell lines [115,116,142]. Citronellol showed its anti-cancer activity via increased reactive oxygen species production, alterations in mitochondrial permeability, DNA fragmentation, changes in cytochrome c activities, and activation of caspase, against the MCF-7 human mammary tumor cell line [142].…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Another component of the EO of lemongrass, citronellol, is also found to exert cytotoxic effects on several cancer cell lines [115,116,142]. Citronellol showed its anti-cancer activity via increased reactive oxygen species production, alterations in mitochondrial permeability, DNA fragmentation, changes in cytochrome c activities, and activation of caspase, against the MCF-7 human mammary tumor cell line [142]. The cytotoxicity of α-bisabolol has been reported against human and rat malignant glioma cancer cell lines.…”

Section: Anticancer Activitymentioning

confidence: 99%

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Mukarram¹,

Choudhary²,

Khan³

et al. 2021

Preprint

View full text Add to dashboard Cite

The prominent cultivation of lemongrass relies on the pharmacological incentives of its essential oil. The lemongrass essential oil (LEO) has a significant amount of citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol in addition to numerous other bioactive compounds. These components confer various medicinal activities to LEO including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These attributes are commercially exploited in pharmaceutical, cosmetics, and food preservations industries. Furthermore, the employment of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, these effects have not been assessed yet in humans. Further studies on the anticancer mechanisms exerted by lemongrass components are required. The present review intends to provide a timely discussion on the relevance of lemongrass extracts in cancer and health treatment, and in food industry applications.

show abstract

“…Another component of the EO of lemongrass, citronellol, is also found to exert cytotoxic effects on several cancer cell lines [ 141 , 142 , 143 ]. Citronellol showed its anticancer activity via increased reactive oxygen species production, alterations in mitochondrial permeability, DNA fragmentation, changes in cytochrome c activities, and activation of caspase, against the MCF-7 human mammary tumour cell line [ 144 ]. The cytotoxicity of α-bisabolol has been reported against human and rat malignant glioma cancer cell lines.…”

Section: Leo Therapeuticsmentioning

confidence: 99%

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

et al. 2021

View full text Add to dashboard Cite

The prominent cultivation of lemongrass (Cymbopogon spp.) relies on the pharmacological incentives of its essential oil. Lemongrass essential oil (LEO) carries a significant amount of numerous bioactive compounds, such as citral (mixture of geranial and neral), isoneral, isogeranial, geraniol, geranyl acetate, citronellal, citronellol, germacrene-D, and elemol, in addition to other bioactive compounds. These components confer various pharmacological actions to LEO, including antifungal, antibacterial, antiviral, anticancer, and antioxidant properties. These LEO attributes are commercially exploited in the pharmaceutical, cosmetics, and food preservations industries. Furthermore, the application of LEO in the treatment of cancer opens a new vista in the field of therapeutics. Although different LEO components have shown promising anticancer activities in vitro, their effects have not yet been assessed in the human system. Hence, further studies on the anticancer mechanisms conferred by LEO components are required. The present review intends to provide a timely discussion on the relevance of LEO in combating cancer and sustaining human healthcare, as well as in food industry applications.

show abstract

Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells

Cited by 9 publications

References 39 publications

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Lemongrass Essential Oil Components with Antimicrobial and Anticancer Activities

Contact Info

Product

Resources

About