Citric acid bioproduction and downstream processing: Status, opportunities, and challenges

Mores, Sabrina; Vandenberghe, Luciana Porto de Souza; Júnior, Antônio Irineudo Magalhães; Carvalho, Júlio César de; Mello, Ariane Fátima Murawski de; Pandey, Ashok; Soccol, Carlos Ricardo

doi:10.1016/j.biortech.2020.124426

Cited by 40 publications

(43 citation statements)

References 92 publications

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“…It is safe for human health and the environment and is considered almost indispensable and hard to substitute in light of the number of applications in very different sectors, such as food and beverages, the pharmaceutical, nutraceutical and cosmetics industries. The great majority of the produced citric acid (>65%) is addressed to the food and beverage (F&B) sector where it is employed both as a preservative, thanks to its antioxidant properties, and as flavor enhancer, used to balance the sweetness of juices, soft drinks and jams [16,17]. CA is certified as safe (Generally Regarded As Safe) by the Food and Drug Administration in the US and, together with its salts, is EU-approved as a food additive, being indicated as E330 (citric acid), E331 (sodium citrate), E332 (potassium citrate) and E333 (calcium citrate).…”

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

“…Currently, most citric acid globally is produced by submerged fermentation (SmF) with either stirred tank or bubble-column reactors. Compared to surface fermentation, submerged fermentation requires more sophisticated equipment but, in turn, is characterized by higher yields, lower fermentation times, ease of process standardization and automation, and less risk of contamination [16,44].…”

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

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State of the Art on the Microbial Production of Industrially Relevant Organic Acids

et al. 2022

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The industrial relevance of organic acids is high; because of their chemical properties, they can be used as building blocks as well as single-molecule agents with a huge annual market. Organic acid chemical platforms can derive from fossil sources by petrochemical refining processes, but most of them also represent natural metabolites produced by many cells. They are the products, by-products or co-products of many primary metabolic processes of microbial cells. Thanks to the potential of microbial cell factories and to the development of industrial biotechnology, from the last decades of the previous century, the microbial-based production of these molecules has started to approach the market. This was possible because of a joint effort of microbial biotechnologists and biochemical and process engineers that boosted natural production up to the titer, yield and productivity needed to be industrially competitive. More recently, the possibility to utilize renewable residual biomasses as feedstock not only for biofuels, but also for organic acids production is further augmenting the sustainability of their production, in a logic of circular bioeconomy. In this review, we briefly present the latest updates regarding the production of some industrially relevant organic acids (citric fumaric, itaconic, lactic and succinic acid), discussing the challenges and possible future developments of successful production.

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Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

Section: From First Evidence and Studies To Current Pilot Or Commerci...mentioning

confidence: 99%

State of the Art on the Microbial Production of Industrially Relevant Organic Acids

et al. 2022

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show abstract

“…When there is a lot of rain, harvesting stops. You can't store sugar cane stalks because the sugar will immediately start fermenting 3 . In the economic evaluation 6000 full load hours are assumed.…”

Section: General Assumption About the Biomass To Pellets Plantsmentioning

confidence: 99%

“…Sugarcane trash pellet production in Brazil Sugarcane trash pellet for electricity production in Netherlands Sugarcane trash pellet for ethanol production in Netherlands Empty fruit bunch EFB pellet production in Colombia EFB pellet for electricity production in Netherlands EFB pellet for ethanol production in Netherlands Reference pellet system Wood pellet production in North America Reference fossil electricity and liquid fuel Fossil fuel comparator for electricity Fossil fuel comparator for biofuels 6. 3 Life cycle inventory analysis Life cycle inventory tables for the investigated CAPCOM pellet production chains are provided in Annex A.…”

Section: Pathways Product Systemsmentioning

confidence: 99%