Citric Acid: A Multifunctional Pharmaceutical Excipient

Lambros, Maria P.; Tran, Thac; Fei, Qinqin; Nicolaou, Mike

doi:10.3390/pharmaceutics14050972

Cited by 46 publications

(23 citation statements)

References 155 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CA is acidic, and it will make the food acidic to some extent and can mask the bitterness and improve the palatability of the food [ 38 ]. However, inappropriate pH changes can alter protein solubility, rheological properties, and gel characteristics, thus affecting the quality of 3D printed mackerel mince products.…”

Section: Resultsmentioning

confidence: 99%

Regulation of the Colour Change of 3D-Printed Mackerel Mince (Scomber scombrus) Based on Purple Potato Powder and Citric Acid

Jin

Xie

Wang

et al. 2023

Foods

View full text Add to dashboard Cite

The present study evaluates the effect of purple potato (PP) powder and citric acid (CA) on the regulation of the colour change of 3D (three-dimensional) printed mackerel mince (Scomber scombrus). In addition, the effects of PP and CA content on the 3D-printability and quality of mackerel mince were also investigated. The results showed that an increase in PP and CA concentrations gradually brightened the product colour and turned it pink. Furthermore, an increase in PP concentration and added CA reduced the fluidity and loss of water in mackerel mince. Proper PP and CA concentrations moderately increased the storage modulus (G′), loss modulus (G″), and yield stress of mackerel mince, making it suitable for 3D printing. At the same time, an increase in PP and CA concentrations enhanced the umami and sweet taste of mackerel mince but reduced the fishy and sour taste, and the degree of preference was within the acceptable range, except for PP1%-CA0%. It was found that, when the 3D-printing accuracy of mackerel-mince samples reached more than 97% and was acceptable, the optimal PP and CA concentrations for realizing the regulation of L*, a*, and b* were 1.00~3.00% and 0.09~0.32%, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

Regulation of the Colour Change of 3D-Printed Mackerel Mince (Scomber scombrus) Based on Purple Potato Powder and Citric Acid

Jin

Xie

Wang

et al. 2023

Foods

View full text Add to dashboard Cite

show abstract

“…ARP and all films exhibited a low dissolution rate at pH 6.8, suggesting that ARP has pH-dependent solubility. Maintaining the pH-dependent solubility of API with citric acid can provide a taste-masking effect without releasing bitter drugs in the oral mucosa [ 55 ]. Notably, the dissolution rate of ARP-loaded HPC 3D printed films rapidly reached the highest point within 30 min (pH 1.2; 82.15 ± 1.36%, pH 4.0; 82.11 ± 2.38%, and pH 6.8; 22.85 ± 0.89%).…”

Section: Resultsmentioning

confidence: 99%

Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole

et al. 2022

View full text Add to dashboard Cite

The objective of this study was to design and evaluate an orodispersible film (ODF) composed of aripiprazole (ARP), prepared using a conventional solvent casting technique, and to fuse a three-dimensional (3D) printing technique with a hot-melt extrusion (HME) filament. Klucel® LF (hydroxypropyl cellulose, HPC) and PE-05JPS® (polyvinyl alcohol, PVA) were used as backbone polymers for 3D printing and solvent casting. HPC-, PVA-, and ARP-loaded filaments were applied for 3D printing using HME. The physicochemical and mechanical properties of the 3D printing filaments and films were optimized based on the composition of the polymers and the processing parameters. The crystalline states of drug and drug-loaded formulations were investigated using differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). The dissolution and disintegration of the 3D-printed films were faster than those of solvent-cast films. HPC-3D printed film was fully disintegrated within 45 ± 3.5 s. The dissolution rate of HPC films reached 80% within 30 min at pH 1.2 and pH 4.0 USP buffer. There was a difference in the dissolution rate of about 5 to 10% compared to PVA films at the same sampling time. The root mean square of the roughness (Rq) values of each sample were evaluated using atomic force microscopy. The higher the Rq value, the rougher the surface, and the larger the surface area, the more salivary fluid penetrated the film, resulting in faster drug release and disintegration. Specifically, The HPC 3D-printed film showed the highest Rq value (102.868 nm) and average surface roughness (85.007 nm). The puncture strength of 3D-printed films had desirable strength with HPC (0.65 ± 0.27 N/mm2) and PVA (0.93 ± 0.15 N/mm2) to prevent deformation compared to those of marketed film products (over 0.34 N/mm2). In conclusion, combining polymer selection and 3D printing technology could innovatively design ODFs composed of ARP to solve the unmet medical needs of psychiatric patients.

show abstract

“…(Igliński et al, 2022) Citric acid is a weak tricarboxylic acid; the pKa values of its three carboxylate are 3.15, 4.78 and 6.40 respectively. (Lambros et al, 2022) On the other hand Sodium-bicarbonate was use as an effervescence agent. According to US-FDA, when sodium-bicarbonate and citric acid mix together; react rapidly in water and release CO 2 ; release of CO 2 enhances the dissolution of active pharmaceutical ingredient.…”

Section: Methodsmentioning

confidence: 99%

Untitled

2023

Pak. J. Pharm. Sci.,

View full text Add to dashboard Cite

The purpose of the current study was to develop stable effervescent-tablets without controlling area relativehumidity; temperature and no requirement of special packaging. Current 3 2 factorial-design experimental studies were conducted in the Research Laboratory of Pharmaceutics, Hamdard University. Duration of study is from December-2021 to November-2022. Various paracetamol based effervescent formulations (F1-F9) were prepared with different molarratio of citric-acid anhydrous and sodium-bicarbonate as independent variables. Design-Expert ® software was used to graphically express the influence of each factor. By novel approach; tablets were compressed at ambient temperature and relative-humidity; acid components were kept on one-side and basic ingredients on another side; both sides were separated by an inert-layer. Tablets were kept at accelerated humidity and temperature in normal packing for six months; after six months, F6 formulation was found acceptable based on effervescence-time (120 sec), pH-value (5.5) and other quality criterion. Parameters of assay, effervescence-time, pH-value and carbon-dioxide content were found within the set-limit. Hence; novel approach for developing effervescent formulation by separating acid components at one-side and basic ingredients on another side of tablet through inert-layer is workable under room temperature and humidity. It is expected that commercial production of tablets by this technique may reduce cost of effervescent products and no requirement for special packaging.

show abstract

Citric Acid: A Multifunctional Pharmaceutical Excipient

Cited by 46 publications

References 155 publications

Regulation of the Colour Change of 3D-Printed Mackerel Mince (Scomber scombrus) Based on Purple Potato Powder and Citric Acid

Regulation of the Colour Change of 3D-Printed Mackerel Mince (Scomber scombrus) Based on Purple Potato Powder and Citric Acid

Investigation of Patient-Centric 3D-Printed Orodispersible Films Containing Amorphous Aripiprazole

Untitled

Contact Info

Product

Resources

About