Citomorfologia do líquido cefalorraqueano do recém-nascido normal

Ja, Livramento; Br, da Luz; Haussen,; Spina-França, A.

doi:10.1590/s0004-282x1974000300005

Cited by 5 publications

(8 citation statements)

References 5 publications

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“…Of these, nine fulfilled the inclusion criteria (Fig. 1) [8][9][10][11][12][13][14][15][16]. No additional relevant studies were identified by hand searching of references.…”

Section: Systematic Review Resultsmentioning

confidence: 99%

“…Therefore, 7 studies were included in the review, all of which were case series. These reported the results from 270 term (in 5 studies) [12][13][14][15][16] and 96 preterm infants (in 2 cohorts) [8][9][10][11]. The number of participants in each study ranged from 19 to 108 (mean 52, median 43).…”

Section: Systematic Review Resultsmentioning

confidence: 99%

“…Four studies reported the CSF WBC count in term infants. This ranged from 0 to 130.0 cells/μL (though this upper value was deemed potentially indicative of meningitis by the authors) with means ranging from 1.5 to 7.3 cells/μL [12,[14][15][16]. There was no difference between the CSF WBC count on day 2 and 7 (p = 0.96) [15].…”

Section: Wbc Countmentioning

confidence: 99%

“…Table 2 and Figure 2 summarize the CSF WBC count for individual neonates in the four studies in which these data were reported [10,12,15,16]…”

Section: Wbc Countmentioning

confidence: 99%

“…Four studies (two in preterm neonates) reported the neutrophil count in CSF [8,10,14,16]. In 96 preterm neonates [8,10], the mean neutrophil count was 0.3 and 2.1 cells/μL, respectively (range 0-1.4 in 1 study, not specified in the other) and in 129 term neonates [14,16] it was 0.8 and 2.9 (range 0-65.0) cells/μL. In term neonates, the CSF neutrophil count was higher in week 1 and 2 compared to week 3 and 4 (p < 0.05) [14].…”

Section: Neutrophil Countmentioning

confidence: 99%

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Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Zimmermann

Curtis

2021

Neonatology

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Background: The diagnosis of neonatal meningitis often rests on microscopic and biochemical findings in the cerebrospinal fluid (CSF). There is ongoing uncertainty about age-related normal values for CSF findings in neonates, and many previous studies have included infants in whom antibiotics were administered before lumbar puncture or in whom viral meningitis was not excluded. Methods: A systematic search was done using MEDLINE and EMBASE to identify original studies which investigated CSF normal values in either healthy neonates or febrile neonates in whom bacterial and viral meningitis were reliably excluded. Results: We identified seven studies investigating 270 term and 96 preterm neonates. There were minimal differences between preterm and term neonates in the CSF white blood cell (WBC) count and glucose concentration. In contrast, the CSF neutrophil count and protein concentration were influenced by gestational and chronological age. In the four studies that reported individual patient data, in 95% of cases the CSF WBC count was <12 cells/μL in preterm and <10 cells/μL in term neonates, the neutrophil count was <16 and 8 cells/μL, and the protein concentration was <210 and 110 mg/dL, respectively. Conclusion: The normal range for CSF parameters in neonates is different to that in older infants, and some parameters are influenced by gestational and chronological age. CSF parameters alone are not sufficiently reliable to exclude meningitis.

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“…Of these, nine fulfilled the inclusion criteria (Fig. 1) [8][9][10][11][12][13][14][15][16]. No additional relevant studies were identified by hand searching of references.…”

Section: Systematic Review Resultsmentioning

confidence: 99%

Section: Systematic Review Resultsmentioning

confidence: 99%

Section: Wbc Countmentioning

confidence: 99%

“…Table 2 and Figure 2 summarize the CSF WBC count for individual neonates in the four studies in which these data were reported [10,12,15,16]…”

Section: Wbc Countmentioning

confidence: 99%

Section: Neutrophil Countmentioning

confidence: 99%

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Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Zimmermann

Curtis

2021

Neonatology

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Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Lamb,

Rent,

Brannon

et al. 2023

Journal of the Pediatric Infectious Diseases Society

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Background To evaluate the diagnostic and predictive utility of cerebrospinal fluid (CSF) white blood cell (WBC) components in the diagnosis of bacterial meningitis in infants discharged from the neonatal intensive care unit (NICU). Methods We identified a cohort of infants discharged from a Pediatrix NICU between 1997 and 2020 who did not have an immunodeficiency, had at least 1 CSF culture collected within the first 120 days of life, and at least 1 CSF laboratory specimen obtained on the day of culture collection. We only included an infant’s first CSF culture and excluded cultures from CSF reservoirs and those growing contaminants or nonbacterial organisms. We examined the utility of CSF WBC components to diagnose or predict bacterial meningitis by calculating sensitivity, specificity, positive and negative predictive values, likelihood ratios, and area under the receiver operating curve (AUC) at different cutoff values for each parameter. We performed subgroup analysis excluding infants treated with antibiotics the day before CSF culture collection. Results Of the 20 756 infants that met the study inclusion criteria, 320 (2%) were diagnosed with bacterial meningitis. We found (AUC [95% CI]) CSF WBC count (0.76 [0.73–0.79]), CSF neutrophil count (0.74 [0.70–0.78]), and CSF neutrophil percent (0.71 [0.67–0.75]) had the highest predictive values for bacterial meningitis, even when excluding infants with early antibiotic administration. Conclusions No single clinical prediction rule had the optimal discriminatory power for predicting culture-proven bacterial meningitis, and clinicians should be cautious when interpreting CSF WBC parameters in infants with suspected meningitis.

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Meningites bacterianas no recém-nascido: estudo de 20 casos

Ribeiro

Armbrust-Figueiredo

Melo

1977

Arq. Neuro-Psiquiatr.

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The cases of 20 patients admitted with purulent meningitis in the neonatal period are reported. The authors analyse the importance in recognizing the minimal signals and symptoms, as weel as the clinical patterns of the manifested disease; Some considerations are draw about the values of the early diagnostic before the high incidence of mortality and the gravity of sequaele that occur besides the high doses and long term antimicrobial therapy.

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Citomorfologia do líquido cefalorraqueano do recém-nascido normal

Cited by 5 publications

References 5 publications

Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Normal Values for Cerebrospinal Fluid in Neonates: A Systematic Review

Diagnostic Utility of Cerebrospinal Fluid White Blood Cell Components for the Identification of Bacterial Meningitis in Infants

Meningites bacterianas no recém-nascido: estudo de 20 casos

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